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Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats

, : Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats. Bmc Complementary and Alternative Medicine 13(): 368-368

The effects of curcumin on the activities and gene expression of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (G-ST), B-cell CLL/lymphoma 2 (Bcl-2) and insulin like growth factor-1 (IGF-1) in diabetic rats were studied. Twenty four rats were assigned to three groups (8 rats for each). Rats of first group were non diabetic and rats of the second group were rendered diabetic by streptozotocin (STZ). Both groups received vehicle, corn oil only (5 ml/kg body weight) and served as negative and positive controls, respectively. Rats of the third group were rendered diabetic and received oral curcumin dissolved in corn oil at a dose of 15 mg/5 ml/kg body weight for 6 weeks. Diabetic rats showed significant increase of blood glucose, thiobarbituric acid reactive substances (TBARS) and activities of all antioxidant enzymes with significant reduction of reduced glutathione (GSH) compare to the control non diabetic group. Gene expression of Bcl2, SOD, CAT, GPX and GST was increased significantly in diabetic untreated rats compare to the control non diabetic group. The administration of curcumin to diabetic rats normalized significantly their blood sugar level and TBARS values and increased the activities of all antioxidant enzymes and GSH concentration. In addition, curcumin treated rats showed significant increase in gene expression of IGF-1, Bcl2, SOD and GST compare to non diabetic and diabetic untreated rats. Curcumin was antidiabetic therapy, induced hypoglycemia by up-regulation of IGF-1 gene and ameliorate the diabetes induced oxidative stress via increasing the availability of GSH, increasing the activities and gene expression of antioxidant enzymes and Bcl2. Further studies are required to investigate the actual mechanism of action of curcumin regarding the up regulation of gene expression of examined parameters.


PMID: 24364912

DOI: 10.1186/1472-6882-13-368

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Cogulu, D.; Sabah, E.; Kutukculer, N.; Ozkinay, F., 2005: Evaluation of the relationship between caries indices and salivary secretory IgA, salivary pH, buffering capacity and flow rate in children with Down's syndrome. The aim of this study was to compare the caries prevalence and salivary secretory IgA (sIgA), salivary pH, buffering capacity and flow rate between Down's syndrome (DS) and control subjects.Seventy-three institutionatised children with DS and...

Sheth, S.; Fishman, E.K., 2007: Imaging of the inferior vena cava with MDCT. The purpose of this pictorial essay is to illustrate the role of MDCT in the diagnosis of disease processes affecting the inferior vena cava (IVC). High-speed MDCT has the potential to replace traditional imaging techniques in the evaluation of pa...

Anonymous, 2016: Correction. Hypertension 67(3): E5-E5

Qi, W.; Yuan, W.; Yan, J., 2016: The fabrication of glucose-sensitive insulin carriers with layer-by-layer assembly technique. Journal of Controlled Release 213: E110-E110

Lu, X.; Lu, X.; Wang, Z.C.; Iglehart, J.Dirk.; Zhang, X.; Richardson, A.L., 2008: Predicting features of breast cancer with gene expression patterns. Data from gene expression arrays hold an enormous amount of biological information. We sought to determine if global gene expression in primary breast cancers contained information about biologic, histologic, and anatomic features of the disease i...

Voigt, R.L., 1963: Gahi-2 hybrid millet seed production in the Salt River Valley. Data are provided from trials held in 1962 on the agronomic characters of the four inbred lines used to develop Pennisetum glaucum 'Gabi 2' and on the lodging and yield of the hybrid.

Cid, J.María.; Duvey, G.; Cluzeau, P.; Nhem, V.; Macary, K.; Raux, A.; Poirier, N.; Muller, J.; Boléa, C.; Finn, T.; Poli, S.; Epping-Jordan, M.; Chamelot, E.; Derouet, F.; Girard, F.; Macdonald, G.J.; Vega, J.Antonio.; de Lucas, A.Isabel.; Matesanz, Eón.; Lavreysen, H.; Linares, Mía.Lourdes.; Oehlrich, D.; Oyarzábal, J.; Tresadern, G.; Trabanco, Aés.A.; Andrés, J.Ignacio.; L.P.ul, E.; Imogai, H.; Lutjens, R.; Rocher, J-Philippe., 2010: Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor. A series of 1,5-disubstituted pyridones was identified as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor 2 (mGluR2) via high throughput screening (HTS). Subsequent SAR exploration led to the identification of several...

Nuhoglu, Y., 2006: A new approach to air pollution determination using annual rings: dendro-chemical elemental analysis of annual rings by SEM-EDS. This paper presents a new approach to air pollution determination through the use of elemental analysis of the annual tree rings (ATRs) of Turkish red pine (Pinus brutia). For this aim, every annual ring width was measured on the cross-section whe...

Anderson, L.J.; Coombs, R.A.; Tsou, C.; Hierholzer, J.C., 1984: Use of the biotin-avidin system to study the specificity of antibodies against respiratory syncytial virus. To characterize the specificity of monoclonal antibodies against respiratory syncytial virus, we developed a technique which combined the biotin-avidin system, immunoprecipitation, and transblot electrophoresis. The viral proteins were first bioti...

Yamane, T.; Miyatake, T., 2011: Induction of oviposition by injection of male-derived extracts in two Callosobruchus species. In some insect species, certain substances in the seminal fluid of males induce egg production and laying in females. We determined the effects of male-derived substances on female oviposition behaviour in two Callosobruchus species, C. chinensis...