geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Current status of healthy human skin models: can histone deacetylase inhibitors potentially improve the present replacement models?


, : Current status of healthy human skin models: can histone deacetylase inhibitors potentially improve the present replacement models?. Skin Pharmacology and Physiology 27(1): 36-46

Histone deacetylase inhibitors (HDACi), a relatively new group of epigenetic agents, are being investigated as powerful chemotherapeutics because of their antiproliferative and prodifferentiation effects both in vitro and in vivo, in various tumor cell lines. Only little is known with respect to their effects on normal cells. Yet, to understand tissue pathology and evaluate potential effects of new chemical entities in tissue homeostasis, insight into the physiology of healthy tissue is necessary. Therefore, this review addresses the effects of HDACi on healthy human primary skin cell cultures and three-dimensional epidermal models. In general, HDACi exert an effect on both the epidermal morphology and differentiation process of human skin. The latter is manifested through cell cycle arrest, disorganization of the basal layer, thinning of the stratum spinosum and thickening of the stratum corneum, reorganization of the cytoskeleton and increased formation of cornified envelopes. This overview shows that, although only a limited number of reports exist, these molecules might be an interesting tool for the development and study of new human skin models.

US$19.90

PMID: 23941820

DOI: 10.1159/000351363


Other references

Youngman, R.R.; Sanderson, J.P.; Barnes, M.M., 1988: Life history parameters of Tetranychus pacificus McGregor (Acari: Tetranychidae) on almonds under differential water stress. The effect of water stress on specific life history parameters of Tetranychus pacificus McGregor mites was tested in a greenhouse using potted almond trees. Significantly more eggs were deposited by females on trees under variable water stress tha...

Cheuvront, S.N.; Haymes, E.M.; Sawka, M.N., 2002: Validity of sweat loss estimates for women running in a warm and cool environment. Medicine & Science in Sports & Exercise 34(5 Supplement): S84, May

Simha, V.; Garg, A., 2006: Lipodystrophy: lessons in lipid and energy metabolism. Lipodystrophies are rare inherited and acquired disorders characterized by the selective loss of adipose tissue. Despite marked phenotypic and genotypic heterogeneity, most lipodystrophic syndromes predispose to similar metabolic complications see...

Blanc-Lapierre, A.; Rousseau, M-Claude.; Weiss, D.; El-Zein, M.; Siemiatycki, J.; Parent, M-Élise., 2016: Lifetime report of perceived stress at work and cancer among men: A case-control study in Montreal, Canada. The association between perceived workplace psychological stress, over the entire work career, and cancer among men has never been assessed. This was explored in the context of a population-based case-control study conducted in Montreal, Canada. 3...

Zahur, M.; Afroz, A.; Rashid, U.; Khaliq, S., 2015: Dermatomycoses: challenges and human immune responses. The most prevalent skin infections are mainly caused by species of dermatophytes of the genera Trichophyton, Microsporum, and Epidermophyton that infect keratinized tissues and stratum corneum of skin and hair. Besides proteases with putative role...

Ariza, L.Miguel., 2005: Defensive eating. Scientific American 292(5): 25-25

Guzzo, T.J.; Dluzniewski, P.; Orosco, R.; Platz, E.A.; Partin, A.W.; Han, M., 2010: Prediction of mortality after radical prostatectomy by Charlson comorbidity index. Prostate cancer treatment should depend on the characteristics of a patient's prostate cancer as well as overall health status. A possible adverse consequence of poor patient selection is a lack of benefit because of premature death from anot...

Holste, E.K.; Matzner, S.L., 2001: Environmental effects on xylem cavitation in Phaseolus vulgaris. Ecological Society of America Annual Meeting Abstracts 86: 294

Codeço, C.Torres., 2006: The reversible catalytic model and the mathematical theory of epidemics. Revista de Saude Publica 40(2): 205-206

Kim, J-Oh.; Jung, J-Tae., 2007: Performance of membrane-coupled organic acid fermentor for the resources recovery form municipal sewage sludge. This study focused on the treatment performance of membrane-coupled organic acid fermentor (MOF) with intermittent reciprocal air/ozone backwashing for the keeping of high permeation flux as well as for the effective recovery of dissolved organic...