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Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients

, : Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients. Journal of Infectious Diseases 211(2): 178-186

Chronic cytomegalovirus (CMV) infection has been associated with immunosenescence and immunoactivation in the general population. In human immunodeficiency virus type 1 (HIV-1)-infected people, CMV coinfection, in addition to residual HIV replication and microbial translocation, has been proposed as a key factor in sustaining immune activation, even in individuals with a controlled HIV load. Patients from the ICONA Study with at least 1 CMV immunoglobulin G (IgG) test available without active CMV disease were included in the analysis. AIDS-defining event or AIDS-related death and severe non-AIDS-defining event or non-AIDS-related death were taken as clinical progression end points. Independent predictors of CMV were identified by multivariable logistic regression. Probabilities of reaching the end points were estimated by survival analyses. A total of 6111 subjects were included, of whom 5119 (83.3%) were CMV IgG positive at baseline. Patients with CMV IgG positivity at baseline were more likely to develop a severe non-AIDS-defining event/non-AIDS-related death (adjusted hazard ratio [HR], 1.53 [95% confidence interval {CI}, 1.08-2.16]. In particular, CMV seropositivity was an independent risk factor for cardiovascular and cerebrovascular diseases (adjusted HR, 2.27 [95% CI, .97-5.32]). In our study population, CMV/HIV coinfection was associated with the risk of severe non-AIDS-defining events/non-AIDS-related death, especially with cardiovascular and cerebrovascular events, independently of other prognostic factors. This finding supports a potential independent role of CMV coinfection in vascular/degenerative organ disorders in HIV-infected subjects.


PMID: 25081936

DOI: 10.1093/infdis/jiu417

Other references

Suess E.; Ziegler V., 1981: Selected problems in dermatoses induced by synthetic substances. Wissenschaftliche Zeitschrift der Karl-Marx-Universitaet Leipzig Mathematisch-Naturwissenschaftliche Reihe 30(5): 486-489

Takahashi, T.; Nakamura, K.; Ikeda, E.; Furuichi, A.; Kido, M.; Nakamura, Y.; Kawasaki, Y.; Noguchi, K.; Seto, H.; Suzuki, M., 2013: Longitudinal MRI study of the midline brain regions in first-episode schizophrenia. This magnetic resonance imaging (MRI) study investigated the prevalence and size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP) in 64 first-episode schizophrenia patients and 64 controls, of whom longitudinal data were availabl...

Lukaszewska, J.; Lewandowski, K., 2008: Cabot rings as a result of severe dyserythropoiesis in a dog. An 11-year-old female Dachshund was presented with depression, diarrhea, weight loss, and radiographic evidence of masses involving the liver, spleen, and cranial lobe of the right lung. Results of a CBC included severe nonregenerative anemia (HCT...

Hoffman R.A., 1975: Pineal gland and behavior. Eleftheriou, Basil E And Richard L Sprott (Ed ) Hormonal Correlates Of Behavior, Vol 1 A Lifespan View; Vol 2 An Organismic View Xvii+439p(Vol 1 ); Xvii+367p(Vol 2 ) Illus Plenum Press: New York, N Y , Usa; London, England Isbn 0-306-37504-4(Vol 1 ); Isbn 0-306-37505-2(Vol 2 ) 697-721

Lee, J.Goo.; Hwang, J.; Hwang, H.Jung.; Jeon, O.Sung.; Jang, J.; Kwon, O.; Lee, Y.; Han, B.; Shul, Y-Gun., 2016: A New Family of Perovskite Catalysts for Oxygen-Evolution Reaction in Alkaline Media: BaNiO3 and BaNi(0.83)O(2.5). Establishment of a sustainable energy society has been strong driving force to develop cost-effective and highly active catalysts for energy conversion and storage devices such as metal-air batteries and electrochemical water splitting systems. Th...

Aliev, I.M., 1988: Effect of supplementing the diet with mucus-forming bacilli on growth and development of chickens. Chickens were fed on a basal diet without or with protein from mucus-forming bacilli (Bacillus mucilaginosus) at 0.2 g/kg. Chickens given the bacterial protein grew more quickly and, at the end of feeding, weighed 66.5 g more than chickens given t...

Meier, R.M., 1982: The collaborative model in transitioning patients from the hospital to day treatment. International Journal of Partial Hospitalization 1(3): 279-285

Seiler, T.; Derse, M.; Pham, T., 1992: Repeated excimer laser treatment after photorefractive keratectomy. Scarring or undercorrection occurs in a small percentage of patients after myopic photorefractive keratectomy. Scarring occurred in 1.8% of 298 patients with a baseline myopia of 6.0 diopters or less, increasing to 8.8% in those with corrections o...

Boon, W.H., 1975: A surveillance system to prevent kernicterus in Singapore infants. Journal of the Singapore Paediatric Society 17(1): 1-9

Wohlsein, P.; Bartmann, CP.; Kirpal, G.; Hildebrandt, T.; Peters, M., 2001: Tuberculosis, molar malocclusion and urogenital lesions in a captive Asian elephant (Elephas maximus). A 38-year-old female nulliparous Asian elephant exhibited marked weight loss for several months. Although a mal-formed left mandibular molar was partially cut off by surgery the condition of the animal did not improve. Due to the poor prognosis th...