+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Death induced by CD95 or CD95 ligand elimination

, : Death induced by CD95 or CD95 ligand elimination. Cell Reports 7(1): 208-222

CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL expression, and preferentially affects cancer cells. All tumors that formed in mouse models of low-grade serous ovarian cancer or chemically induced liver cancer with tissue-specific deletion of CD95 still expressed CD95, suggesting that cancer cannot form in the absence of CD95. Death induced by CD95R/L elimination (DICE) is characterized by an increase in cell size, production of mitochondrial ROS, and DNA damage. It resembles a necrotic form of mitotic catastrophe. No single drug was found to completely block this form of cell death, and it could also not be blocked by the knockdown of a single gene, making it a promising way to kill cancer cells.


PMID: 24656822

DOI: 10.1016/j.celrep.2014.02.035

Other references

Swatland, H.J., 1978: Acid phosphatase activity of intra muscular mast cells from cattle and sheep. Web-like spreads of perimysium produced by pulling apart the myofibers of bovine and ovine sternomandibularis muscles were stained with methylene blue. Mast cells of the perimysium had a classical appearance with strongly basophilic cytoplasmic gr...

Gourley, C.A.; Braidwood, G.D., 1971: The use of dust respirators in the prevention of recurrence of farmer's lung. The results of trials on a farmer suffering from the disease and on other, more severely affected, farmers suggest that by wearing a replaceable filter type B respirator and using it properly recurrence of the disease can be prevented.

Cincu, R.; Rodriguez Ortigosa, C.; Quiroga, J.; Prieto, J., 1996: Effect of S-adenosylmethionine on glutathione metabolism in leukotriene D-4-induced liver injury. Journal of Hepatology 25(SUPPL 1): 130

Reuhl, K.R., 1992: Cytoskeleton and cell adhesion Critical targets of toxic agents. Neurotoxicology (Little Rock) 13(4): 871

Labruna, M.B.; Resende, J.S.; Martins, N.R.S.; Jorge, M.A., 1999: Cryopreservation of an avian spirochete strain in liquid nitrogen. Serum samples were obtained from chickens with clinical signs of spirochaetosis, thought to be caused by Borrelia anserina. Sterilized glycerol (at a dilution of 1:2, v/v) or dimethyl sulfoxide (DMSO; 1:10 v/v) were added to the sera before storag...

Watson Neal; Stacey Brian; Mackay John; Fondyga Tony, 2000: Drill-pipe logging string redesign cuts costs for Hibernia. Oil and Gas Journal 98(32): 43-46

van den HEUVEL-HEYMANS.G., 1950: Dextran, substitute for blood plasma, and homeostasis of arterial pressure. In dogs anesthetized with chloralose circulatory collapse was induced by bleeding and the blood pressure homeostasis was tested by carotid occlusion. 6% dextran infusions restored not only arterial pressure and respiration but also the physiologic...

McKinney, E.D., 1969: Activity of acetylcholinesterase in brains of male Cottontail rabbits. Journal of Wildlife Management, 33: 418-420

Madsen, N.H., 1939: The dairy industry in India. The annual production of milk is estimated to be 6, 400 million gal. Of this 31 per cent. is used as liquid milk, 53 per cent. for the making of ghee and the remainder for other products.

Aoki, N.; Muko, M.; Ohta, E.; Ohta, S., 2008: C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity. An ethyl acetate-soluble fraction of a methanol extract from the stems of Angelica keiskei was subjected to chromatographic separation to give three new chalcones, designated as xanthokeismins A-C (1-3), in addition to a known chalcone, xanthoange...