+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Defining stem cell dynamics in models of intestinal tumor initiation

, : Defining stem cell dynamics in models of intestinal tumor initiation. Science 342(6161): 995-998

Cancer is a disease in which cells accumulate genetic aberrations that are believed to confer a clonal advantage over cells in the surrounding tissue. However, the quantitative benefit of frequently occurring mutations during tumor development remains unknown. We quantified the competitive advantage of Apc loss, Kras activation, and P53 mutations in the mouse intestine. Our findings indicate that the fate conferred by these mutations is not deterministic, and many mutated stem cells are replaced by wild-type stem cells after biased, but still stochastic events. Furthermore, P53 mutations display a condition-dependent advantage, and especially in colitis-affected intestines, clones harboring mutations in this gene are favored. Our work confirms the previously theoretical notion that the tissue architecture of the intestine suppresses the accumulation of mutated lineages.


PMID: 24264992

DOI: 10.1126/science.1243148

Other references

Reiss, J., 1976: Cytology of Thamnidium elegans Link. II. Distribution and behaviour of nuclei in hyphae, sporangiophores and sporangiospores. The resting nuclei in hyphae, sporangiophores and sporangiospores of sporangia and sporangiola of Thamnidium elegans consist of a large centrals nucleolus and a shell of chromatin surrounding the nucleolus. Division of the nucleus in hyphae and sp...

Testolin, R., 2002: The analysis of genetic identity. This paper examines four aspects dealing with the elucidation of the genetic identity of propagation materials in the nursery: (1) to ascertain the genetic identity of the propagation material; (2) to protect the property and propagation rights of...

Hamilton, S.M.; Zhang, Z.; Teel, R.W., 1994: Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activity. The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is metabolized by various isozymes of cytochrome P-450 present in microsomes. In this study, we examined the effects of the isothiocyanate homologues, phenyl iso...

Matula; Roy; Mourad; McNamara; Suslick, 1995: Comparison of multibubble and single-bubble sonoluminescence spectra. Physical Review Letters 75(13): 2602-2605

Meyers, S., 1995: Treatment of Clostridium difficile infection. Mount Sinai Journal of Medicine, New York 62(3): 183-187

Anonymous, 1984: What's new in hand surgery?. Revue de Chirurgie Orthopedique et Reparatrice de L'appareil Moteur 70 Suppl 2: 11-25

Pridmore, R.W., 2000: Unique and binary hues as functions of luminance and illuminant color temperature, and relations with invariant hues. For aperture color 3 s stimuli, the four unique hues, and at times the four (equally-balanced) binary hues, were measured for: (1) adapting white color temperatures 2850, 3400, 5500, 6500 K; and (2) luminance (L) for 5 and 6 log L ranges (about 0....

Biswas, N.M.; Sen Gupta, R.; Chattopadhyay, A.; Choudhury, G.R.y; Sarkar, M., 2001: Effect of atenolol on cadmium-induced testicular toxicity in male rats. Cadmium-induced stress adversely affects testicular activity and causes sympathetic stimulation. To investigate the effect of atenolol, a beta-adrenergic receptor blocker, on testicular androgen synthesis after cadmium treatment, adult Sprague-Daw...

Staiber, W., 2013: Germ line-limited and somatic chromosomes of Acricotopus lucidus differ in distribution and timing of alterations of histone modifications in male gonial mitosis and meiosis. Special chromosomes limited to the germ line (=Ks) and exceptional genetic events such as elimination mitoses and a monopolar migration of the Ks in the last gonial mitosis are specific features of the complex chromosome cycle occurring in the chi...

Germanson, T.P.; Lanzino, G.; Kongable, G.L.; Torner, J.C.; Kassell, N.F., 1998: Risk classification after aneurysmal subarachnoid hemorrhage. BACKGROUND: Prediction of patient outcome is an important aspect of the management and study of aneurysmal subarachnoid hemorrhage (SAH). In the present study, we evaluated the prognostic value of two multivariate approaches to risk classification...