+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Defining the canonical form of T-cell-mediated rejection in human kidney transplants

, : Defining the canonical form of T-cell-mediated rejection in human kidney transplants. American Journal of Transplantation 10(4): 810-820

Banff defines T-cell-mediated rejection (TCMR) using nonspecific lesions and arbitrary cutoffs, with no external gold standard. We reexamined features of TCMR using exclusively molecular definition independent of histopathology. The definition was derived from mouse kidney transplants with fully developed TCMR, and is based on high expression of transcripts reflecting IFNG effects and alternative macrophage activation. In 234 human kidney transplant biopsies for cause phenotyped by microarrays, we identified 26 biopsies meeting these criteria. After excluding three biopsies with unrelated diseases, all 23 biopsies had typical Banff lesions of TCMR (inflammation, tubulitis), with v lesions in 10/23. Banff histopathology diagnosed 18 as TCMR, 1 as mixed and 4 as borderline. Despite marked changes in transcriptome indicating tissue injury and dedifferentiation, all kidneys with molecularly defined TCMR, even with v lesions or late rejection, demonstrated excellent recovery of function at 6 months with no graft loss (mean follow-up 2.5 years). Thus TCMR defined exclusively by molecules manifests TCMR-related lesions and function impairment, but good recovery and survival, even with late rejection or arteritis. This combination of pathologic, clinical and molecular features constitutes the typical or canonical T-cell-mediated rejection.


PMID: 20132168

DOI: 10.1111/j.1600-6143.2009.03007.x

Other references

Olley J.M.; Murray A.S.; Wallbrink P.J., 1996: Identifying sediment sources in a partially logged catchment using natural and anthropogenic radioactivity. Zeitschrift fuer Geomorphologie Supplementband

Krigbaum J.S., 1989: Biocultural adaptation in prehistoric vermont usa. American Journal of Physical Anthropology 78(2): 256-257

Stiell, I.G.; Clement, C.M.; Brison, R.J.; Rowe, B.H.; Borgundvaag, B.; Aaron, S.D.; Lang, E.; Calder, L.A.; Perry, J.J.; Forster, A.J.; Wells, G.A., 2013: A risk scoring system to identify emergency department patients with heart failure at high risk for serious adverse events. There are no validated guidelines to guide physicians with difficult disposition decisions for emergency department (ED) patients with heart failure (HF). The authors sought to develop a risk scoring system to identify HF patients at high risk for...

Colonaş, F.; Codiţă, D., 1969: The "record" type syringe adapted for sialography. Stomatologia 16(5): 471-472

Jansen, L.A.; Ross, L.F., 2001: Patient confidentiality and the surrogate's right to know. Journal of Law, Medicine & Ethics 28(2): 137-143

Borisov, G.A.; Lajhinen, O.M., 1965: Mechanization of calculating the optimum road alignment. A note on the use of digital computers for calculating the best road alignment to minimize the volume of earth to be moved.

Glomm, W., R.; Bidegain, B., F.; Volden, S.; Sjoblom, J., 2006: A quartz crystal microbalance study of the adsorption of fluorescein-5-isothiocyanate onto gold surfaces. The interaction of fluorescein-5-isothiocyanate (F5ITC) with gold surfaces-either uncoated or pre-coated with passivating layers of either sodium citrate (citrate), bis(p-sulfonatophenyl)phenylphosphine dihydrate dipotassium (BSPP), Pluronic P123...

Laing, R.; Tan, S.; McDouall, J.; Wright, C.; Niven, B.; Wilson, C., 2003: Pretibial injury in patients aged 50 years and over. To establish the rate of, and identify circumstances surrounding, pretibial injury in patients aged 50 years and over. The rate of pretibial injury was estimated from national hospital discharge data from the New Zealand Health Information Service...

Chaillou, C.; Reinaud, P.; Sjafei, D.; Lefebvre, B.; Roubaud, P., 1989: Over-maturation of oocytes and embryonic development of the egg in common carp. A discussion of the effects of oocyte aging on the activation and viability of oocytes of common carp (Cyprinus carpio). Oocyte viability is affected by the environmental temp. of the spawning [female][female], season and the quality of pituitary...

Othman, R.; Worrall, A.; Wilton, D.C., 1994: Some properties of a human group II phospholipase A2 expressed from a synthetic gene in E. coli. Biochemical Society Transactions 22(3): 317s-317s