geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer's disease


, : Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer's disease. Journal of Inorganic Biochemistry 103(11): 1579-1584

Aluminum (Al) exposure has been reported to be a risk factor for Alzheimer's disease (senile dementia of Alzheimer type), although the role of Al in the etiology of Alzheimer's disease remains controversial. We examined the presence of Al in the Alzheimer's brain using energy-dispersive X-ray spectroscopy combined with transmission electron microscopy (TEM-EDX). TEM-EDX analysis allows simultaneous imaging of subcellular structures with high spatial resolution and analysis of small quantities of elements contained in the same subcellular structures. We identified senile plaques by observation using TEM and detected Al in amyloid fibers in the cores of senile plaques located in the hippocampus and the temporal lobe by EDX. Phosphorus and calcium were also present in the amyloid fibers. No Al could be detected in the extracellular space in senile plaques or in the cytoplasm of nerve cells. In this study, we demonstrated colocalization of Al and beta-amyloid (Abeta) peptides in amyloid fibers in the cores of senile plaques. The results support the following possibilities in the brains of patients with Alzheimer's disease: Al could be involved in the aggregation of Abeta peptides to form toxic fibrils; Al might induce Abeta peptides into the beta-sheet structure; and Al might facilitate iron-mediated oxidative reactions, which cause severe damage to brain tissues.

US$19.90

PMID: 19744735

DOI: 10.1016/j.jinorgbio.2009.07.023


Other references

Lemche, J.; Pegram, R.G., 1987: Control of cattle ticks using flumethrin in central Zambia. Flumethrin pour-on formulation was used on a herd of cattle every 14 days for 24 weeks. Compared with an untreated herd, treatment controlled 95% of all species. Treatment was 100% effective against Boophilus decoloratus, 96.6% against Hyalomma tr...

Tittel, G., 1974: Mainstreams and political-ideological function of rural sociology in the German Democratic Republic. Kooperation 8 (1) 45-46

Lee, S.; Kim, C., 1978: Rapid and simple determinatio. Han'guk Ch'uksan Hakhoe chi = Korean journal of animal sciences 20(1): 77-81

Schleyer, F., 1963: Comparative Experiments On The Abo Group Classification Of Hemolytic Blood Samples Using The Lattes And Saturation Methods And The Absorption-Elution Method. Zeitschrift für Hygiene und Infektionskrankheiten; Medizinische Mikrobiologie, Immunologie und Virologie 149: 281-286

Ademuyiwa, F.O.; Gao, F.; Hao, L.; Morgensztern, D.; Aft, R.L.; Ma, C.X.; Ellis, M.J., 2015: US breast cancer mortality trends in young women according to race. Young age at diagnosis has a negative prognostic impact on outcome in patients with breast cancer (BC). In the current study, the authors sought to determine whether there is a differential effect of race and examined mortality trends according to...

Nemkova, S.N.; Rudenko, E.V., 2003: The state of the fat body and the lifetime of honey bees (Apis mellifera) invaded by Varroa jacobsoni. The fat body cells of the honey bees Apis mellifera Linnaeus, 1758 is shown to be reduced at the invasion intensity 1-2 (1153.01[plus or minus]139.05 mkm2) and 3-4 mites Varroa jacobsoni Oudemans, 1904 per bee (952.68[plus or minus]137.72 mkm2) co...

Jun, J.Hwa.; Joo, C-Ki., 2016: MicroRNA-124 Controls Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in the Retinal Pigment Epithelium by Targeting RHOG. MicroRNA-124 (miR-124) is thought to be involved in the epithelial-mesenchymal transition (EMT) of RPE. We investigated the regulation of TGF-β1-induced EMT by miR-124 in human RPE cells (ARPE-19). Expression of miR-124 was evaluated after TGF-β...

Perry Eric F.; Andrews David E., 1982: Slaking modes of geologic materials and their impact on embankment stabilization. The results of a study of the impacts of slaking on surface mine spoils in the Appalachian Basin are discussed. Representative samples were collected for laboratory analyses. Extensive qualitative and semiquantitative data were collected on the be...

Li, K-Che.; Huang, L.L.H.; Liang, J-Hao.; Chan, M-Che., 2016: Simple approach to three-color two-photon microscopy by a fiber-optic wavelength convertor. NlmCategory="UNASSIGNED">A simple approach to multi-color two-photon microscopy of the red, green, and blue fluorescent indicators was reported based on an ultra-compact 1.03-μm femtosecond laser and a nonlinear fiber. Inside the non...

Hart, Lj, 1978: Choosing the right engine oil. Journal of logging management: 9 (9) 1688-1691