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Detoxification of gold nanorods by conjugation with thiolated poly(ethylene glycol) and their assessment as SERS-active carriers of Raman tags


, : Detoxification of gold nanorods by conjugation with thiolated poly(ethylene glycol) and their assessment as SERS-active carriers of Raman tags. Nanotechnology 21(23): 235601-235601

We present an effective, low cost protocol to reduce the toxicity of gold nanorods induced by the presence of cetyltrimethylammonium bromide (CTAB) on their lateral surface as a result of the synthesis process. Here, we use thiolated methoxy-poly(ethylene) glycol (mPEG-SH) polymer to displace most of the CTAB bilayer cap from the particle surface. The detoxification process, chemical and structural stability of as-prepared mPEG-SH-conjugated gold nanorods were characterized using a number of techniques including localized surface plasmon resonance (LSPR), transmission electron microscopy (TEM) and surface-enhanced Raman spectroscopy (SERS). In view of future applications as near-infrared (NIR) nanoheaters in localized photothermal therapy of cancer, we investigated the thermal behaviour of mPEG-SH-conjugated gold nanorods above room temperature. We found a critical temperature at around 40 degrees C at which the adsorbed polymer layer is susceptible to undergo conformational changes. Additionally, we believe that such plasmonic nanoprobes could act as SERS-active carriers of Raman tags for application in cellular imaging. In this sense we successfully tested them as effective SERS substrates at 785 nm laser line with p-aminothiophenol (pATP) as a tag molecule.

US$19.90

PMID: 20463383

DOI: 10.1088/0957-4484/21/23/235601


Other references

Murphy, M.Z., 1988: Shifting market power feeds registered nursing shortage. American Nurse 20(7): 28-28

Leão, L.E.; Buffolo, E.; Andrade, J.C.; Succi, J.E.; Carvalho, A.C.; Lustre, W.G.; Gerola, L.R.; Tavares, J.R.; Gallucci, G., 1984: Surgical treatment of isolated, associated or recurrent ventricular septal defect by transaortic approach. Arquivos Brasileiros de Cardiologia 43(6): 403-414

Attwood, T.K., 2000: The quest to deduce protein function from sequence: The role of pattern databases. In the wake of the numerous now-fruitful genome projects, we have witnessed a 'tsunami' of sequence data and with it the birth of the field of bioinformatics. Bioinformatics involves the application of information technology to the manag...

Sarantonis, E.G.; Karayannis, M.I., 1990: Use of a trinitrobenzenesulphonate electrode for the kinetic determination of copper(II) and reducing sugars. Copper was determined using the catalytic effect of colloidal Cu(OH)2 on the reduction of trinitrobenzenesulphonate (TNBS) by Na2S at 20 degrees C in carbonate buffer at pH 11; the potential of a TNBS electrode increased linearly with time at a ra...

Manzo, A.; DengC.T.; Pei, R.; Loon, J.; Semana, G.; Banh, L.; Chen, M.; Coblentz, J.; Denham, S.; Liu, A.; Woo, G.; Lee, J.H., 1994: Serological heterogeneity of DR2 elucidated by monoclonal antibodies. Human Immunology 39(2): 144

Roberts T.M.; Fisher B.E.A., 1985: Estimated trends in dry and wet sulfur deposition over the uk between 1970 and 1982 and effects on crop growth. Journal of the Science of Food & Agriculture 36(4): 262-263

Buonanno, F.S.; Ball, M.R.; Laster, D.W.; Moody, D.M.; McLean, W.T., 1978: Computed tomography in late-infantile metachromatic leukodystrophy. Computed tomography of 2 patients with late-infantile metachromatic leukodystrophy (MLD) demonstrated generalized white matter lucency and moderate ventricular enlargement. CAT scan findings in other white matter diseases likely to be confused cli...

Buchanan, G.; Yang, M.; Harris, J.M.; Nahm, H.S.; Han, G.; Moore, N.; Bentel, J.M.; Matusik, R.J.; Horsfall, D.J.; Marshall, V.R.; Greenberg, N.M.; Tilley, W.D., 2001: Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function. The androgen receptor (AR), a member of the steroid receptor superfamily of nuclear transcription factors, mediates androgen signaling in diverse target tissues. Here we report AR gene mutations identified in human prostate cancer and the autochth...

Debray, C.; Housset, P.; Martin, E.; Marche, C.; Nicolaidis, C.L., 1964: Gastric Biopsy Under Visual Control By Aspiration-Section And Controlled Cytodiagnosis In The Diagnosis Of Gastric Cancer. La Semaine des Hopitaux 40: 141-148

Mizuno, S.; Harada, M.; Shibuya, T.; Ohno, Y.; Miyamoto, T.; Nagafuji, K.; Niho, Y., 1994: Apoptotic cell death in Epstein-Barr virus positive natural killer cell leukaemia. Blood 84(10 SUPPL 1): 610A