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Diabetes and the risk of coronary heart disease in the general Japanese population: the Japan Public Health Center-based prospective (JPHC) study


, : Diabetes and the risk of coronary heart disease in the general Japanese population: the Japan Public Health Center-based prospective (JPHC) study. Atherosclerosis 216(1): 187-191

Although diabetes has a great impact on coronary heart disease (CHD) in Western populations, there is limited evidence that diabetes influences CHD in the Japanese population. The Japan Public Health Center-based prospective (JPHC) study conducted a follow-up of 31,192 individuals aged 40-69 years with no history of cardiovascular disease or cancer. Subjects were classified at baseline as normal, borderline diabetic or diabetic based on fasting and non-fasting blood glucose levels and the use of medication to treat diabetes. A Cox proportional hazards model was used to determine the association between diabetes and the risk of fatal and non-fatal CHD events after adjustment for potential confounders. During 12.9 years of follow-up (1990-2006), we identified 266 fatal and non-fatal coronary events using validated criteria. With normal individuals serving as a control, the hazard ratios for total incident CHD events after adjusting for sex, age, study community and fasting were 1.65 (95% CI, 1.19-2.29) and 3.05 (2.03-4.59) in the borderline and diabetic groups, respectively. These associations remained significant after adjustment for conventional risk factors. The population attributable fractions (PAF) of borderline diabetes and diabetes for CHD events were 6.9% and 6.3%, respectively. Furthermore, there was a trend for an association between an impaired fasting glucose (5.6-6.9 mmol/l) and an increased risk of CHD events. This prospective study suggests that diabetes and elevated glucose levels are associated with incident CHD in the general Japanese population. The PAF of diabetes for fatal and non-fatal coronary events was estimated to be moderate.

US$19.90

PMID: 21300356

DOI: 10.1016/j.atherosclerosis.2011.01.021


Other references

Singh, G.; Rai, A.; Eng, J.; Raufman, J.P., 1993: Use of iodine-125 yttrium-39 exendin-4 to characterize exendin-TGLP-1 receptors on gastric chief cells. Gastroenterology 104(4 SUPPL ): A854

Askenazi, D., 1976: The pathogenesis of coeliac disease. Harefuah 91(7): 202-203

Sutiak, L.; Palencár, J.; Slamen, J., 1990: Postoperative hypoxemia in aged surgical patients. The authors analyze postoperative hypoxaemia in a group of 48 patients aged 60 years or more after operation in the upper half of the abdomen. Hypoxaemia with values below 8 kPa in the arterial blood stream which are classified as a respiratory in...

Chen, L.; Kato, Y.; Sano, H.; Watanabe, S.; Yoneda, M.; Hayakawa, M.; Sadato, A.; Irie, K.; Negoro, M.; Karagiozov, K.L.; Kanno, T., 2007: Management of complex, surgically intractable intracranial aneurysms: the option for intentional reconstruction of aneurysm neck followed by endovascular coiling. A limited series of patients with aneurysm were reviewed retrospectively to analyze strategies for integrating microsurgical and endovascular techniques in the management of complex, surgically intractable aneurysms. Four patients were managed in...

Wen, G.; Ringseis, R.; Eder, K., 2010: Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron. Recent studies provided strong evidence to suggest that organic cation transporter 2 (OCTN2) is a direct target gene of peroxisome proliferator-activated receptor alpha (PPARalpha). However, subsequent studies failed to demonstrate a functional pe...

Hugueney M.; Mein P.; Ringeade M., 1992: New dating of mammalian deposits from the Digne Basin (Lambert and Barles, southeastern France), probable extenson of the Aquitaine transgression in this area. Paleontologia y Evolucion 24-25: 123-134

D.S.lva, S.L.; Rowan, E.G.; Albericio, F.; Stábeli, R.G.; Calderon, L.A.; Soares, A.M., 2015: Animal toxins and their advantages in biotechnology and pharmacology. Biomed Research International 2014: 951561-951561

Diaz, A.C.istina; Fernandez Gimenez, A.V.; Haran, N.S.; Fenucci, J.L., 2001: Reproductive performance of male Argentine red shrimp Pleoticus muelleri Bate (Decapoda, Penaeoidea) in culture conditions. Spermatophore and sperm quality of male Argentine red shrimp Pleoticus muelleri held under laboratory conditions was evaluated using compound spermatophore weight, sperm count and percentage of live sperm as indicators. Thirty-seven males of 5 to...

Kolavic, S.A.; Kimura, A.; Simons, S.L.; Slutsker, L.; Barth, S.; Haley, C.E., 1997: An outbreak of Shigella dysenteriae type 2 among laboratory workers due to intentional food contamination. Context: Shigella dysenteriae type 2 is rare in the United States, and outbreaks associated with this pathogen are uncommon. Objective: To determine the magnitude and source of an outbreak of S. dysenteriae type 2. Design: Retrospective cohort. Se...

Schneeweiss, A.; Seitz, J.; Smetanay, K.; Schuetz, F.; Jaeger, D.; Bachinger, A.; Zorn, M.; Sinn, H-Peter.; Marmé, F., 2015: Efficacy of nab-paclitaxel does not seem to be associated with SPARC expression in metastatic breast cancer. To evaluate the predictive value of the expression of the secreted protein acidic and rich in cysteine (SPARC) for nab-paclitaxel in metastatic breast cancer (MBC). Forty-four patients with progressive MBC were prospectively treated with nab-pacli...