+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Diagnostic and prognostic value of alpha-fetoprotein, des-γ-carboxy prothrombin and squamous cell carcinoma antigen immunoglobulin M complexes in hepatocellular carcinoma

, : Diagnostic and prognostic value of alpha-fetoprotein, des-γ-carboxy prothrombin and squamous cell carcinoma antigen immunoglobulin M complexes in hepatocellular carcinoma. Minerva Medica 102(5): 363-371

The hepatocellular carcinoma (HCC) is one of the most common malignant tumors. It carries a poor survival rate and has an increasing incidence worldwide. In most cases, HCC is diagnosed at a late stage. Therefore, the prognosis of patients with HCC is generally poor and has a less than 5% 5-year survival rate. The aim of this study was compare the accuracy of α-fetoprotein (AFP), des-γ- carboxy prothrombin (DCP), squamous cell carcinoma antigen-immunoglobulin M complexes (SCCA-IgM Cs) in the early diagnosis and in the prognosis of HCC. A literature search identified the markers for hepatocellular carcinoma. A search of the literature was made using cancer literature and the PubMed database for the following keywords: "markers and HCC", "α-fetoprotein (AFP) and HCC", "Des-γ-carboxy prothrombin"(DCP) and HCC, "squamous cell carcinoma antigen-immunoglobulin M complexes" (SCCA-IgM Cs). Despite the large number of studies devoted to the immunohistochemistry of HCC, at the present time, the absolute positive and negative markers for HCC are still lacking, and even those characterized by very high sensitivity and specificity do not have an universal diagnostic usefulness. In conclusion none of the three biomarkers (AFP, DCP, SCCA-IgM Cs) is optimal. According to recent reviews, these biomarkers should be measured simultaneously and in combination with imaging techniques to increase the sensitivity, specificity, diagnostic accuracy and to make a reliable prognosis. Currently the recommended screening strategy for patients with cirrhosis includes the determination of serum AFP levels and an abdominal ultrasound every six months to detect HCC at an earlier stage.


PMID: 22193346

Other references

McKinley, S., 1994: 'Critical care and our ageing society'. Australian Critical Care 7(1): 5-5

Tada, M.; Kirchberger, M.A., 1976: Significance of the membrane protein phospholamban in cyclic AMP-mediated regulation of calcium transport by sarcoplasmic reticulum. Phospholamban (molecular weight = 22,000), which serves as a regulator of Ca transport ATPase (molecular weight = 100,000) of cardiac sarcoplasmic reticulum (SR), becomes resistant to tryptic digestion upon phosphorylation by cAMP-dependent protei...

Chhabra, A.; Mishra, S.; Kumar, A.; Titiyal, J.Singh., 2006: Atropine-induced lens extrusion in an open eye surgery. A 2-month-old male baby undergoing penetrating keratoplasty (PKP) under general anesthesia developed bradycardia and a decrease in heart rate to 53 b x min(-1) when stay sutures were taken through the superior and inferior recti. A bolus of 0.1 mg...

Eguchi, E.; Ogawa, Y.; Okamoto, K.; Mochizuki, K., 1994: Fatty acid compositions of arthropod and cephalopod photoreceptors: Interspecific, seasonal and developmental studies. Fatty acid compositions of the compound eyes of insects (soldier-bug. Hemiptera, and silk moth, Lepidoptera), crustaceans (crayfish and grapsid crab, Decapoda) and inner and outer segments of visual cells of a squid (Cephalopoda, Mollusca) were an...

Hernandez, Mercedes Reyes, 2010: First record of the family Neoliodidae Acari Oribatida from Cuba. The family Neoliodidae Sellnick, 1928 is recorded for the first time from Cuba, based on specimens of the genera Wades Berlese, 1888 and Teleioliodes Grandjean, collected in the soil of a semideciduous forest at San Antonio de los Banos, La Habana...

Saucier, G., 1969: Up-to-date methods of teaching and medical sciences. Methods of training and instruction; methods of evaluation. Laval Medical 40(2): 152-154

Anonymous, 1983: Guidelines and recommendations for safe handling of antineoplastic agents. Medical Journal of Australia 1(9): 426-428

de Mestier, L.; Walter, T.; Brixi, H.; Lombard-Bohas, C.; Cadiot, G., 2015: Sunitinib achieved fast and sustained control of VIPoma symptoms. VIPomas are rare-functioning neuroendocrine tumors (NETs). Overproduction of vasointestinal peptide (VIP) leads to the Verner-Morrison syndrome, whose management is challenging when refractory to somatostatin analogs. Two patients with progressive...

Farrell, S.F.; Khan, S.; Osmotherly, P.G.; Sterling, M.; Cornwall, J.; Rivett, D.A., 2017: Lateral atlantoaxial joint meniscoid volume in individuals with whiplash associated disorder: A case-control study. Lateral atlantoaxial (LAA) joints are established sources of nociceptive input in chronic whiplash associated disorder (WAD). These joints contain intra-articular meniscoids that may be damaged in whiplash trauma. LAA joint meniscoid morphology ha...

Putnam, H.M.; Adams, D.K.; Zelzion, E.; Wagner, N.E.; Qiu, H.; Mass, T.; Falkowski, P.G.; Gates, R.D.; Bhattacharya, D., 2017: Divergent evolutionary histories of DNA markers in a Hawaiian population of the coral iMontipora capitata. We investigated intra- and inter-colony sequence variation in a population of the dominant Hawaiian coral <i>Montipora capitata</i> by analyzing marker gene and genomic data. Ribosomal ITS1 regions showed evidence of a reticulate histo...