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Diagnostic and therapeutic review of cystic parathyroid lesions


, : Diagnostic and therapeutic review of cystic parathyroid lesions. Hormones 11(4): 410-418

Parathyroid cysts (PC) are uncommon entities in routine clinical practice. The vast majority are nonfunctioning and are commonly present as asymptomatic nodular cervical lesions. PC should be considered in the differential diagnosis of an asymptomatic neck mass. Large PC can manifest with compressive symptoms of the surrounding tissues. The aim of this study is to describe nine new cases of PC and review the current literature regarding the clinical presentation, the aetiopathology, the diagnostic procedures, as well as the therapeutic approaches for this relatively rare clinical entity. METHODS-PATIENTS: We present nine new patients (7 females and 2 males) diagnosed with PC, which in three were ectopic. The diagnosis of PC was based on the elevated levels of PTH in the cysts fluid. Six of the patients had nonfunctioning parathyroid lesions, while the other three had functioning ones. Patients with functioning PC had elevated serum calcium and PTH levels. Five out of nine of the cases had no symptoms, while two patients had compressive symptoms and the other two had signs and symptoms of hypercalcaemia. Needle aspiration (NA) was performed in five out of six patients with nonfunctioning PC. Surgery was the treatment in all three patients with functioning PC. Remission after NA was achieved in four out of five patients with non-functioning PC (follow-up time: 17.7±2.3 months). In two of them, two and three aspirations were needed. One patient with nonfunctioning PC submitted to surgery with no previous NA. Patients with functioning PC maintained remission after surgery (mean follow-up time: 22.1±2.9 months). In one of them, a second surgery was performed due to the co-existence of an ectopic parathyroid adenoma. The diagnosis of a PC can be established by finding high levels of PTH in the fluid collected by the aspiration of the cyst. PTH and Ca levels in the serum can differentiate functioning from nonfunctioning PC. The treatment of choice in nonfunctioning cysts is aspiration. Surgical removal of the cyst is indicated in hyperfunctioning cysts in cases of relapse after NA in nonfunctioning cysts and when compressive symptoms are present. Based on our series, which appears to be one of the largest reported, we propose a diagnostic algorithm to guide the diagnostic and therapeutic approach to PC.

US$29.90

PMID: 23422763


Other references

Aust, Wolfram, 1966: Pleoptics and orthoptics. This volume, the result of clinical and experimental study, is a practical guide to the conservative therapy of concomitant squint.

Barrett, B.; Bulat, T.; Schultz, S.K.; Luther, S.L., 2017: Factors Associated With Wandering Behaviors in Veterans With Mild Dementia: A Prospective Longitudinal Community-Based Study. To investigate baseline factors associated with caregiver-reported wandering among community-dwelling veterans with mild dementia. Veterans with mild dementia (N = 143) and their caregivers participated in a 2-year prospective longitudinal study....

Wacker, A.; Mennigmann, H.D.; Szybalski, W., 1962: Effects of "visible" light on 5-bromouracil-labelled DNA. Nature 196: 685-686

Gong, H.; Bickham, B.P.; Woolley, A.T.; Nordin, G.P., 2017: Custom 3D printer and resin for 18 μm × 20 μm microfluidic flow channels. While there is great interest in 3D printing for microfluidic device fabrication, to-date the achieved feature sizes have not been in the truly microfluidic regime (<100 μm). In this paper we demonstrate that a custom digital light processor s...

Thompson, R.C.; Karim, A.M., 1982: The accuracy of protein biosynthesis is limited by its speed high fidelity selection by ribosomes of aminoacyl transfer rna ternary complexes containing guanosine 5' gamma thio tri phosphate. Guanosine 5'-[.gamma.-thio]triphosphate (GTP[.gamma.S]) forms a stable ternary complex with polypeptide chain elongation factor Tu(EF-Tu) and aminoacyl-tRNA, and this complex binds rapidly and tightly to a properly programed ribosome. However...

D.Monte, Donato A., 2001: A model of genetic-environmental interactions for Parkinsons disease. Neurotoxicology (Little Rock) 22(1): 139, February

Casey, L.C.; Fletcher, J.R.; Zmudka, M.I.; Ramwell, P.W., 1985: The role of thromboxane in primate endotoxin shock. Previous studies have suggested an important role of thromboxane (Tx) in the pathogenesis of endotoxin shock in the rat. The present study evaluated the role of thromboxane in an LD70 primate model of endotoxin shock by administering 6 mg/kg of en...

Krishnaswamy Rama; Seal Robert R.I.I., 1998: Ecological and carbon isotope data for acidophilic algae from abandoned mine sites in Vermont and Virginia. Abstracts with Programs Geological Society of America: , Pages 129. 1998.

Ho, G.Y-H.; Eikelboom, J.W.; Hankey, G.J.; Wong, C-Ru.; Tan, S-Li.; Chan, J.B-C.; Chen, C.P.L-H., 2006: Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients. Background and Purpose - Increased plasma total homocysteine (tHcy) levels are a risk factor for stroke and can be reduced with vitamin therapy. However, data on the tHcy-lowering effects of vitamins are limited largely to white populations. Thus,...

Kampelmacher, E.H.; van Jansen, L.M., 1971: Reduction of Salmonella in compost in a hog-fattening farm oxidation vat. Journal - Water Pollution Control Federation 43(7): 1541-1545