geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Diagnostic value of anti-cyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis


, : Diagnostic value of anti-cyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis. Bmc Musculoskeletal Disorders 8(): 37-37

Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been of diagnostic value in Northern European Caucasian patients with rheumatoid arthritis (RA). In these populations, anti-CCP antibodies are associated with the HLA-DRB1 shared epitope. We assessed the diagnostic value of anti-CCP antibodies in Greek patients with RA where the HLA shared epitope was reported in a minority of patients. Using an enzyme-linked immunosorbent assay (ELISA) (CCP2) kit, we tested anti-CCP antibodies in serum samples from 155 Greek patients with RA, 178 patients with other rheumatic diseases, and 100 blood donors. We also determined rheumatoid factor (RF) and compared it to anti-CCP antibodies for area under the curve (AUC), sensitivity, specificity and likelihood ratios. Sensitivity of anti-CCP2 antibodies and RF for RA was 63.2% and 59.1%, and specificity was 95.0% and 91.2%, respectively. When considered simultaneously, the AUC for anti-CCP antibodies was 0.90 with 95% CI of 0.87 to 0.93 and the AUC for RF was 0.71 with 95% CI of 0.64 to 0.77. The presence of both antibodies increased specificity to 98.2%. Anti-CCP antibodies were positive in 34.9% of RF-negative RA patients. Anti-CCP antibodies showed a correlation with the radiographic joint damage. Anti-CCP-positive RA patients had increased the swollen joint count and serum CRP concentration compared to anti-CCP-negative RA patients (Mann-Whitney U test, p = 0.01, and p < 0.001, respectively). However, no correlation was found between anti-CCP antibodies and DAS28 score (r = 0.13, p = 0.12). In Greek patients with RA, anti-CCP2 antibodies exhibit a better diagnostic value than RF and a correlation with radiological joint damage and therefore are useful in everyday rheumatology practice.

US$19.90

PMID: 17448247

DOI: 10.1186/1471-2474-8-37


Other references

Cui, R.; Rekasi, H.; Hepner-Schefczyk, M.; Fessmann, K.; Petri, R.M.; Bruderek, K.; Brandau, S.; Jäger, M.; Flohé, S.B., 2016: Human mesenchymal stromal/stem cells acquire immunostimulatory capacity upon cross-talk with natural killer cells and might improve the NK cell function of immunocompromised patients. The suppressive effect of mesenchymal stromal/stem cells (MSCs) on diverse immune cells is well known, but it is unclear whether MSCs additionally possess immunostimulatory properties. We investigated the impact of human MSCs on the responsiveness...

Fox S.E.; Wolfson S.; Ranck J.B.Jr, 1986: Hippocampal theta rhythm and the firing of neurons in walking and urethane anesthetized rats. Recordings were taken from single neurons in the hippocampus and dentate gyrus of rats during walking and urethane anesthesia. Firing histograms for these cells were constructed as a function of the phase of the concurrent extracellularly recorded...

Cavallini G.; Mirachian R.; Angelini G.; Vantini I.; Vaona B.; Gelpi F.; Ederle A.; Scuro L.A., 1976: Evaluation of exocrine pancreatic function by stimulation with caerulein intra muscularly secretin caerulein intra venous rapid injection and infusion and secretin pancreozymin intra venous rapid injection and infusion. Scandinavian Journal of Gastroenterology Supplement 11(41): 29

Gao, X.P.A.; Boebinger, G.S.; Mills, A.P.; Ramirez, A.P.; Pfeiffer, L.N.; West, K.W., 2005: Strongly enhanced hole-phonon coupling in the metallic state of the dilute two-dimensional hole gas. We have studied the temperature dependent phonon emission rate P(T) of a strongly interacting (r(s) > or =22) dilute 2D GaAs hole system using a standard carrier heating technique. In the still poorly understood metallic state, we observe that...

Ikemoto, M.; Okamura, Y.; Kano, M.; Hirasaka, K.; Tanaka, R.; Yamamoto, T.; Sasa, T.; Ogawa, T.; Sairyo, K.; Kishi, K.; Nikawa, T., 2002: A relative high dose of vitamin E does not attenuate unweighting-induced oxidative stress and ubiquitination in rat skeletal muscle. We previously reported that intragastric administration of cysteine could be beneficial to prevent unweighting-induced ubiquitination and degradation of muscle protein in association with redox regulation [Ikemoto et al., Biol. Chem., 383 (2002),...

Probert Frank H., 1910: Deep mining in the Guanajuato District, Mexico. Engineering and Mining Journal Pages 1310-1312

Chulkova, I.P., 1956: Piroplasmosis of dogs in the Tatar A.S.S.R. and its treatment with novoplasmin. Good results were claimed for the parenteral administration of 2-3 doses of 1-2 ml. 0.1% aqueous soln.

Ishihara, K.; Ikeda, S.; Arao, T.; Mori, S.; Ohura, T.; Takahashi, M.; Kato, T.; Kukita, A.; Okamoto, S.; Hirone, T., 1990: Evaluation criteria for chemotherapeutics for malignant skin carcinomas. Malignant skin carcinomas occur in a large variety of forms, among them malignant melanoma with a poor prognosis, such as squamous cell carcinoma, basal cell carcinoma, appendix tumors of skin (e.g., sweat gland carcinoma, sebaceous gland carcinom...

Amzil, Z.; Fresnel, J.; Gal, D. le; Billard, C., 2001: Domoic acid accumulation in French shellfish in relation to toxic species of Pseudo-nitzschia multiseries and P. pseudodelicatissima. Within the French phytoplankton monitoring network (REPHY), domoic acid (DA), the toxin responsible for amnesic shellfish poisoning, was first detected in samples collected in 1998. Toxin analysis by the official method [liquid chromatography with...

Sloan, J.; Holloway, G., 1981: Fractured neck of the femur: the cause of the fall?. Injury 13(3): 230-232