geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Diastereoselective one-pot synthesis of tetrafunctionalized 2-imidazolines


, : Diastereoselective one-pot synthesis of tetrafunctionalized 2-imidazolines. Journal of Organic Chemistry 79(11): 5219-5226

A convenient trans-selective one-pot synthesis of tetrafunctionalized 2-imidazolines is described. Our approach to these valuable heterocyclic scaffolds involves a formal 1,3-dipolar cycloaddition between nitrile ylides or nitrilium triflates and imines. A detailed experimental study in combination with a high-level computational exploration of reaction routes reveals a plausible reaction pathway that accounts for the observed diastereoselectivity.

US$19.90

PMID: 24820129

DOI: 10.1021/jo500790n


Other references

Zhao, H.; Wang, J.; Zheng, Y.; Li, J.; Han, X.; He, G.; Du, Y., 2017: Organic Thiocarboxylate Electrodes for a Room-Temperature Sodium-Ion Battery Delivering an Ultrahigh Capacity. Organic room-temperature sodium-ion battery electrodes with carboxylate and carbonyl groups have been widely studied. Herein, for the first time, we report a family of sodium-ion battery electrodes obtained by replacing stepwise the oxygen atoms w...

Lichtenberg, M.; Kühl, M., 2016: Pronounced gradients of light, photosynthesis and O2 consumption in the tissue of the brown alga Fucus serratus. Macroalgae live in an ever-changing light environment affected by wave motion, self-shading and light-scattering effects, and on the thallus scale, gradients of light and chemical parameters influence algal photosynthesis. However, the thallus mic...

Eisen, A.; Fletcher, G.G.; Gandhi, S.; Mates, M.; Freedman, O.C.; Dent, S.F.; Trudeau, M.E., 2015: Optimal systemic therapy for early breast cancer in women: a clinical practice guideline. The Breast Cancer Disease Site Group of Cancer Care Ontario identified the need for new guidelines for the adjuvant systemic therapy of early-stage breast cancer. The specific question to be addressed was "What is the optimal adjuvant systemi...

Stalker, H.D.; Carson, H.L., 1948: Seasonal changes in gene arrangement frequencies and morphology of Drosophila robusta. Genetics 33(6): 629-629

Hahlbrock, K.; Grisebach, H., 1979: Enzymic controls in the biosynthesis of lignin and flavonoids. Topics reviewed include biosynthetic pathways, and systems used for studies of enzymic control. References to work on parsley cell suspension cultures, swede root discs, Forsythia suspensa xylem tissue, tulip anthers, petunia flowers and leaves, w...

Desai, H.G.; Venugopalan, K.; Philipose, M.; Zaveri, M.P.; Kalro, R.H.; Antia, F.P., 1977: Effect of red chili powder on gastric mucosal barrier and acid secretion. Acid load tests were performed to measure ion fluxes in control subjects and patients with chronic gastritis and duodenal ulcer. The fluxes of H+ from lumen to mucosa and of Na+ and K+ from mucosa to lumen were studied before and during instillati...

Anonymous, 1934: Sweetpotato Quarantine (Domestic). Notice of Quarantine No. 30 (revised). As a precaution against the introduction of Euscepes batatae, Waterh., and Omphisa anastomosalis, Gn., the importation into the United States, of any variety of sweet potato (Ipomoea batatas) from Hawaii or Porto Rico is prohibited, except as auth...

Kout, M.; Kubikova, Z.; Kyselova, V., 1963: Comparison of several tests for detection of leucocytic iso-antibodies. Leukemic leukocytes were used as antigens in testing sera of 205 patients most of whom had blood diseases or transfusion reactions. Tests included agglutination, agar precipitation, passive hemagglutination, antiglobulin serum consumption and comp...

Veuille, Michel, 2000: 1900-2000 How the mendelian revolution came about. Trends in Genetics 16(9): 380, September

McGovern John F., 1967: Foundations for bridges in Massachusetts. Pages 121-124: