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Dietary ω-3 deficiency and IOP insult are additive risk factors for ganglion cell dysfunction

, : Dietary ω-3 deficiency and IOP insult are additive risk factors for ganglion cell dysfunction. Journal of Glaucoma 22(4): 269-277

Dietary deficiencies in ω-3 polyunsaturated fatty acids are known to effect retinal function including retinal ganglion cell (RGC) activity, which may have implications for glaucoma. In this study we consider retinal function after dietary manipulation and intraocular pressure (IOP) stress designed to compromise RGCs. Sprague-Dawley dams were fed either ω-3 sufficient (ω-3, n=15) or deficient (ω-3, n=16) diets 5 weeks before conception with pups subsequently weaned onto their mothers diets. At 20 weeks of age, acute IOP elevation was induced repeatedly through anterior chamber cannulation to 70 mm Hg for 1 hour on 3 separate occasions separated by 1 week. Electroretinograms were recorded 1 week after each IOP elevation to assay the photoreceptors (PIII), ON-bipolar cells (PII), and ganglion/amacrine cells (STR). Repeat IOP insult results in a specific RGC dysfunction (pSTR -14.5%, P<0.035) as does ω-3 deficiency (-26.4%, P<0.01). However, the combination of both causes an even larger RGC functional loss (-40.1%, P<0.001) than does either diet or IOP insult in isolation (P<0.001). Both ω-3 deficiency and repeat acute IOP insult cause RGC dysfunction and the combination of these factors results in a cumulative effect. Our data indicate that sufficient dietary ω-3 improves RGC function making it less susceptible to IOP insult.


PMID: 23221900

DOI: 10.1097/IJG.0b013e318237cac7

Other references

Arrighi, F., 1968: Generalized pustular psoriasis of the Zumbusch type. Bulletin de la Societe Francaise de Dermatologie et de Syphiligraphie 75(5): 600-602

Sumnu, G.; Bayindirli, L.; Ozilgen, M., 1994: Quality control charts for storage of apples. Although the Shewhart charts are widely used for quality control in manufacturing processes, they are not suitable for the storage of fruits where slow quality loss is inevitable. Firmness, weight and ascorbic acid loss data obtained with the Amas...

Katz, D.; Payne, D.; Pauker, S., 2000: Early surgery versus conservative management of dissecting aneurysms of the descending thoracic aorta. Optimal management for patients who present acutely with uncomplicated type III dissections of the descending thoracic aorta remains controversial. Patients with dissecting aneurysms represent a subgroup at high risk of rupture who may benefit fro...

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Pang, A.Y.C.; Lim, S.Ann., 2010: Atypical presentation of central retinal artery occlusion. Annals of the Academy of Medicine, Singapore 39(1): 66-67

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Gems, D.; Clutterbuck, A., 1993: Co-transformation with autonomously-replicating helper plasmids facilitates gene cloning from an Aspergillus nidulans gene library. Autonomously-replicating, marker-less "helper" plasmids were added to transformations of Aspergillus nidulans with plasmids which normally transform by chromosomal integration. This resulted in as much as a 200-fold increase in transform...

Kovacheva Y., 1970: Influence of hypergenetic factors on the organic content of sedimentary rocks. Comparison of abundance of organic residues in sedimentary rocks, from boreholes and outcrops, Caucasus, USSR, and southeastern Bulgaria.

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Dickson, A.J.; Smith, J.K., 1975: Alternatives to freeze-drying for the removal of ethanol from plasma proteins. II. Gel filtration of albumin. Removal of ethanol from highly concentrated solutions of human albumin (Cohn fraction V) by gel filtration on Sephadex G-25 is hindered by the contraction of the gel in ethanolic solution, by incomplete retardation of ethanol compared with other l...