geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) in a 67-year-old patient with chronic coughing


, : Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) in a 67-year-old patient with chronic coughing. Deutsche Medizinische Wochenschrift 139(23): 1245-1248

A 67-year-old woman with a history of chronic obstructive pulmonary disease and breast cancer developed an increase in size and number of pulmonary nodules that had previously been stable over the course of 9 years. Thoracic computed tomography revealed a well-defined pulmonary lesion with a diameter of 1,1 × 1,1 cm, accompanied by multiple bilateral pulmonary nodules with a maximum size of 5 mm. Thoracoscopic resection of the major nodule was extended to a completive resection of an adjacent lung area that operatively showed a macroscopically noticeable hypervascularity. Histopathological examination assigned the larger lesion to a typical carcinoid; the additionally resected hypervascular lung parenchyma confirmed an accumulation of hyperplastic neuroendocrine cells in terms of a diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). Since histological examination showed an entirely resected neuroendocrine tumor classified as typical carcinoid, and considering DIPNECH to be a preinvasive lesion, the therapeutic management consisted of serial imaging by computed tomography. During the last two years, no progression of either the pulmonary lesions or of the obstructive disease was observed. DIPNECH is a rare, primary pulmonary process with proliferation of hyperplastic neuroendocrine cells, affecting principally middle-aged, non-smoking women. It is considered to be a precursor lesion to pulmonary carcinoid tumors. Given its only minor risk of invasive metastatic spread, serial imaging for timely detection of progressing lesions and optimizing of concomitant obstructive pulmonary disease are the preferred treatment approaches.

US$19.90

PMID: 24866961

DOI: 10.1055/s-0034-1370073


Other references

Hoheisel, U., 1980: Anatomie und taxonomische Bedeutung der Legerohre der Opiliones. Unknown

Mehely, L.; Von., 1893: Beitrage zur Herpetologie Transkaukasiens und Armeniens. Zoologischer Anzeiger, XVII 78-86

Zaffagnini, V., 1958: Carcinoma of the penis; notes on 30 cases. Archivio Italiano di Chirurgia 84(2): 133-148

Voncken, J., 1951: Ignorance of the laws and training of the physician. La Presse Medicale 59(26): 514-515

Moens, L.N.; Soetaert, A.; van der Ven, K.; Del-Favero, J.; D.C.en, W.M., 2007: Use of suppression subtractive hybridization PCR for the development of cDNA arrays for the detection of endocrine disruption in carp (Cyprinus carpio). The potential of a variety of xenobiotic compounds to modulate or disrupt the endocrine system of humans and wildlife is now widely recognized. In the present study, we developed a molecular tool for the evaluation of endocrine disruption in comm...

Kawalec, P.; Stawowczyk, E.; Holko, P.; Borowiec, L.; Filipiak, K.J., 2014: Budget Impact Analysis Of Hypertensive Treatment With Indapamide And Amlodipine Single-Pill Combination In The Polish Setting. Value in Health 17(7): A479-A479

Zafarullah M.; Gedamu L., 1988: Structure of the rainbow trout metallothionein b gene differential expression in response to heavy metal inducers. Journal of Cellular Biochemistry Supplement (12 PART D): 343

Wilde, O.R.fael; Literat, B.; D.L.V.ga, A.; Catalan, M.; Cruz, M.L., 1996: Effects of two hand cryopreservation methods on bovine follicular oocytes ultrastructure. Effects of two hand cryopreservation methods on bovine follicular oocytes ultrastructure. The effects of two cryopreservation methods concerning cattle follicular oocytes cell ultrastructure were studied. The present work was done following the Le...

Bosslet, K.; Keweloh, H.C.; Hermentin, P.; Muhrer, K.H.; Sedlacek, H.H.; Schulz, G., 1990: Percolation and binding of monoclonal antibody BW494 to pancreatic carcinoma tissues during high dose immunotherapy and consequences for future therapy modalities. The distribution of the monoclonal antibody (MAb) BW494 in human pancreatic carcinoma biopsies during high dose intravenous immunotherapy was investigated. Using immunohistochemical techniques combined with anti-idiotypic, endothelial cell-specifi...

Akimoto Y.; Kaneko K.; Fujii A.; Yamamoto H., 1992: Ampicillin concentrations in human radicular granuloma following a single oral dose of bacampicillin. Ampicillin concentrations in human serum and radicular granulomas of 42 patients were determined after a single oral dose of bacampicillin (equivalent to 500 mg of ampicillin). Although wide variations were found among both serum and radicular gra...