geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Geography & Life Sciences: Chapter 52643

Chapter 52643 provides bibliographic information on scholary research in geography and in the life sciences.



Discovering the complexities of adolescent compliance to treatment. International Journal of Adolescent Medicine and Health 21(1): 3-8

Discovering the complexity of the metazoan transcriptome. Genome Biology 15(4): 112-112

Discovering the composition of ancient cosmetics and remedies: analytical techniques and materials. Analytical and Bioanalytical Chemistry 401(6): 1727-1738

Discovering the electronic circuit diagram of life: structural relationships among transition metal binding sites in oxidoreductases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 368(1622): 20120257-20120257

Discovering the elusive Beauchêne: the originator of the disarticulated anatomic technique. Clinical Anatomy 24(7): 797-801

Discovering the elusive underlying cause of a bilateral effusion combined with ascites. Proceedings 22(3): 239-241

Discovering the fountain of youth. Nursing New Zealand 16(9): 23-23

Discovering the genetics underlying foetal haemoglobin production in adults. British Journal of Haematology 145(4): 455-467

Discovering the healthcare beliefs and practices of rural mestizo Ecuadorians. An ethnonursing study. Investigacion Y Educacion en Enfermeria 32(2): 326-336

Discovering the hidden sub-network component in a ranked list of genes or proteins derived from genomic experiments. Nucleic Acids Research 40(20): E158-E158

Discovering the impact of preceding units' characteristics on the wait time of cardiac surgery unit from statistic data. Plos One 6(7): E21959-E21959

Discovering the infectome of human endothelial cells challenged with Aspergillus fumigatus applying a mass spectrometry label-free approach. Journal of Proteomics 97(): 126-140

Discovering the influences of complex network effects on recovering large scale multiagent systems. Thescientificworldjournal 2014: 407639-407639

Discovering the leader within yourself: school nurses as leaders. Nasn School Nurse 27(2): 82-87

Discovering the link between nutrition and skin aging. Dermato-Endocrinology 4(3): 298-307

Discovering the literature on Aboriginal diabetes in Canada: a focus on holistic methodologies. Canadian Journal of Nursing Research 40(4): 26-54

Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges. Translational Medicine @ Unisa 8: 12-18

Discovering the meaning of reciprocity for students engaged in service-learning. Nurse Educator 34(1): 6-8

Discovering the mechanisms of strain-dependent response of Staphylococcus aureus to photoinactivation: oxidative stress toleration, endogenous porphyrin level and strain's virulence. Photodiagnosis and Photodynamic Therapy 10(4): 348-355

Discovering the molecular components of intercellular junctions--a historical view. Cold Spring Harbor Perspectives in Biology 1(3): A003061-A003061

Discovering the mortuary during training. Revue de L'infirmiere: 42-43

Discovering the phosphoproteome of the hydrophobic cytochrome c oxidase membrane protein complex. Methods in Molecular Biology 893: 345-358

Discovering the phylodynamics of RNA viruses. Plos Computational Biology 5(10): E1000505-E1000505

Discovering the pivotal role of carbonate in the formation of a bis-phenolate supported Co15 cluster. Chemical Communications 50(17): 2202-2204

Discovering the power of single molecules. Cell 157(1): 4-7

Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity. Plos One 9(3): E91488-E91488

Discovering the role of mitochondria in the iron deficiency-induced metabolic responses of plants. Journal of Plant Physiology 169(1): 1-11

Discovering the route from inflammation to pancreatic cancer. Minerva Gastroenterologica E Dietologica 58(4): 283-297

Discovering the secondary metabolite potential encoded within entomopathogenic fungi. Natural Product Reports 31(10): 1287-1305

Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family--a sticky pursuit. Medical Mycology 46(1): 1-15

Discovering the sequential structure of thought. Cognitive Science 38(2): 322-352

Discovering the social environment anew. Project for qualification for "local associations of responsibility". Pflege Zeitschrift 64(2): 84-85

Discovering the somatotopic organization of the motor areas of the medial wall using low-frequency BOLD fluctuations. Human Brain Mapping 32(10): 1566-1579

Discovering the structure of mathematical problem solving. Neuroimage 97: 163-177

Discovering the sympathomodulatory properties of new calcium channel blockers: an exciting but still snaky journey. Journal of Hypertension 32(9): 1780-1781

Discovering the targets of drugs via computational systems biology. Journal of Biological Chemistry 286(27): 23653-8

Discovering the transcriptional modules using microarray data by penalized matrix decomposition. Computers in Biology and Medicine 41(11): 1041-1050

Discovering the unexpected. IEEE Computer Graphics and Applications 27(5): 15-19

Discovering the unexpected: lessons learned from evaluating conservation education programs in Africa. American Journal of Primatology 72(5): 445-449

Discovering the unknown: detection of emerging pathogens using a label-free light-scattering system. Cytometry. Part A 77(12): 1103-1112

Discovering the unknown: improving detection of novel species and genera from short reads. Journal of Biomedicine & Biotechnology 2011: 495849-495849

Discovering the value of research supervision. Nursing & Health Sciences 12(4): 400-401

Discovering the "anatomy" in students' mind through metaphors. Surgical and Radiologic Anatomy 33(6): 539-542

Discovering thematic objects in image collections and videos. IEEE Transactions on Image Processing 21(4): 2207-2219

Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. Plos Genetics 8(11): E1003083-E1003083

Discovering time-lagged rules from microarray data using gene profile classifiers. Bmc Bioinformatics 12(): 123-123

Discovering transcription and splicing networks in myelodysplastic syndromes. Plos One 8(11): E79118-E79118

Discovering transcription factor binding sites in highly repetitive regions of genomes with multi-read analysis of ChIP-Seq data. Plos Computational Biology 7(7): E1002111-E1002111

Discovering transcription factor regulatory targets using gene expression and binding data. Bioinformatics 28(2): 206-213

Discovering transcriptional modules by Bayesian data integration. Bioinformatics 26(12): I158-I167

Discovering truth. Garcia da Orta and 'discussions of simple healing remedies' (Goa 1563). Sudhoffs Archiv 93(1): 26-66

Discovering tumor suppressor genes through genome-wide copy number analysis. Current Genomics 11(5): 297-310

Discovering unhealthiness: evidence from cluster analysis. Annals of Epidemiology 23(10): 614-619

Discovering unique tobacco use patterns among Alaska Native people. International Journal of Circumpolar Health 72(): -

Discovering up-regulated VEGF-C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen. Veterinary Research 45: 48-48

Discovering vanished paints and naturally formed gold nanoparticles on 2800 years old phoenician ivories using SR-FF-microXRF with the color X-ray camera. Analytical Chemistry 85(12): 5857-5866

Discovering ways that influence the older nurse to continue bedside practice. Nursing Research and Practice 2011: 840120-840120

Discovering weighted patterns in intron sequences using self-adaptive harmony search and back-propagation algorithms. Thescientificworldjournal 2013: 249034-249034

Discovering what it all means. Journal of Religion and Health 26(4): 323-328

Discovering what makes STAT signaling TYK in T-ALL. Cancer Discovery 3(5): 494-496

Discovering women in science. Science 267(5203): 1427-1427

Discovering words in fluent speech: the contribution of two kinds of statistical information. Frontiers in Psychology 3: 590-590

Discovering your inner Gibson: reconciling action-specific and ecological approaches to perception-action. Psychonomic Bulletin & Review 21(6): 1353-1370

Discovering "The Book of the Heart.". Osler Library Newsletter 54(February): 3-4

Discovering, comparing, and combining moderators of treatment on outcome after randomized clinical trials: a parametric approach. Statistics in Medicine 32(11): 1964-1973

Discovertebral (Andersson) lesions in severe ankylosing spondylitis: a study using MRI and conventional radiography. Clinical Rheumatology 29(12): 1433-1438

Discovertebral (Andersson) lesions of the spine in ankylosing spondylitis revisited. Clinical Rheumatology 28(8): 883-892

Discovertebral erosions in patients with enteropathic spondyloarthritis. Journal of Rheumatology 39(12): 2332-2340

Discovertebral lesion in ankylosing spondylitis: differential diagnosis with discitis by magnetic resonance imaging. Modern Rheumatology 12(2): 113-117

Discovery Belux: comparison of rosuvastatin with atorvastatin in hypercholesterolaemia. Acta Cardiologica 63(4): 493-499

Discovery DMPK: changing paradigms in the eighties, nineties and noughties. Expert Opinion on Drug Discovery 4(3): 207-218

Discovery Genetics - The History and Future of Spontaneous Mutation Research. Current Protocols in Mouse Biology 2: 103-118

Discovery Gets a Clean Bill of Health: NASA has made hundreds of fixes to the shuttle; the evidence from Discovery is that virtually everything worked. Science 242(4877): 375-376

Discovery Health's take on Regulation 8. South African Medical Journal 103(12): 887-887

Discovery Interviews with older people: reflections from a practitioner. International Journal of Older People Nursing 3(3): 211-216

Discovery Interviews: a mechanism for user involvement. International Journal of Older People Nursing 3(3): 206-210

Discovery Of A Fresh-Water Lake Near The Sea Of Aral. Science 17(434): 300-300

Discovery Of A Prehistoric Engraving Representing A Mastodon. Science 54(1398): 357-358

Discovery Of An Early Type Of Man In Nebraska. Science 24(620): 628-629

Discovery Of An Orexin Receptor Positive Potentiator. Chemical Science 1(1): -

Discovery Of Ancient Argillite Quarries On The Delaware. Science 21(540): 317-317

Discovery Of Another Ancient Argillite Quarry In The Delaware Valley. Science 22(557): 192-193

Discovery Of Bivalve Crustacea In The Coal Measures Near Pawtucket, R. I. Science 37(944): 191-192

Discovery Of Cretaceous And Older Tertiary Strata In Mongolia. Science 56(1446): 291-293

Discovery Of Further Hominid Remains Of Lower Quaternary Age From The Chou Kou Tien Deposit. Science 67(1727): 135-136

Discovery Of Genes That Affect Human Brain Connectivity: A Genome-Wide Analysis Of The Connectome. Proceedings. IEEE International Symposium on Biomedical Imaging: 542-545

Discovery Of Phosphorus Fixing Compound In The Soil. Science 71(1844): 461-461

Discovery Of Silurian Insects. Science 5(104): 97-97

Discovery Of The Breeding Area Of Kirtlands Warbler In Michigan. Science 18(450): 217-217

Discovery according to blalock. Journal of Investigative Surgery 20(3): 145-147

Discovery analysis of TCGA data reveals association between germline genotype and survival in ovarian cancer patients. Plos One 8(3): E55037-E55037

Discovery and ADMET: Where are we now. Current Topics in Medicinal Chemistry 11(4): 467-481

Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors. Acs Medicinal Chemistry Letters 5(4): 298-303

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. Acs Medicinal Chemistry Letters 4(1): 103-107

Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component. Journal of Biological Chemistry 285(34): 25978-25986

Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity. Acs Medicinal Chemistry Letters 5(9): 1060-1064

Discovery and Characterization of a Novel Carlavirus Infecting Potatoes in China. Plos One 8(6): E69255-E69255

Discovery and Correction of Spurious Low Platelet Counts due to EDTA-Dependent Pseudothrombocytopenia. Journal of Clinical Laboratory Analysis 29(5): 419-426

Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. Acs Medicinal Chemistry Letters 3(3): 203-206

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor. Acs Medicinal Chemistry Letters 1(3): 120-124

Discovery and Evaluation of Polymorphisms in the AKT2 and AKT3 Promoter Regions for Risk of Korean Lung Cancer. Genomics & Informatics 10(3): 167-174

Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors. Acs Medicinal Chemistry Letters 2(8): 632-637

Discovery and Obligation. Science 134(3489): 1572-1574

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles. Acs Medicinal Chemistry Letters 4(6): 551-555

Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2. Acs Medicinal Chemistry Letters 5(4): 378-383

Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds. Acs Medicinal Chemistry Letters 4(4): 397-401

Discovery and Replication of Gene Influences on Brain Structure Using LASSO Regression. Frontiers in Neuroscience 6: 115-115

Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer. Chemistry Central Journal 4: 4-4

Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 21(22): 6793-6799

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorganic & Medicinal Chemistry 16(14): 6965-6975

Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy. Bioorganic & Medicinal Chemistry Letters 21(16): 4828-4831

Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. Journal of Medicinal Chemistry 54(2): 635-654

Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists. Bioorganic & Medicinal Chemistry Letters 24(4): 1239-1242

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists. Journal of Medicinal Chemistry 57(6): 2429-2439

Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorganic & Medicinal Chemistry Letters 19(23): 6623-6626

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorganic & Medicinal Chemistry Letters 23(4): 1114-1119

Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139. Acs Medicinal Chemistry Letters 2(4): 303-306

Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters 24(9): 2057-2061

Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorganic & Medicinal Chemistry Letters 23(18): 5195-5198

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency. Bioorganic & Medicinal Chemistry Letters 24(15): 3641-3646

Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold. Bioorganic & Medicinal Chemistry Letters 22(24): 7388-7392

Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1. Bioorganic & Medicinal Chemistry Letters 20(22): 6592-6596

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase. Bioorganic & Medicinal Chemistry Letters 19(3): 665-669

Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta. Bioorganic & Medicinal Chemistry 17(10): 3519-3527

Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 19(23): 6801-6805

Discovery and SAR of hydantoin TACE inhibitors. Bioorganic & Medicinal Chemistry Letters 20(6): 1877-1880

Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). Journal of Medicinal Chemistry 54(14): 5031-5047

Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype. Bioorganic & Medicinal Chemistry Letters 19(12): 3209-3213

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions. Bioorganic & Medicinal Chemistry Letters 20(7): 2375-2378

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1. Bioorganic & Medicinal Chemistry Letters 20(7): 2370-2374

Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel. Bioorganic & Medicinal Chemistry Letters 24(9): 2053-2056

Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). Bioorganic & Medicinal Chemistry Letters 20(2): 448-452

Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. Bioorganic & Medicinal Chemistry 20(15): 4635-4645

Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists. Bioorganic & Medicinal Chemistry Letters 19(4): 1101-1104

Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors. Bioorganic & Medicinal Chemistry Letters 20(8): 2609-2613

Discovery and SAR of small molecule PAR1 antagonists. Bioorganic & Medicinal Chemistry Letters 20(3): 903-906

Discovery and SAR of spirochromane Akt inhibitors. Bioorganic & Medicinal Chemistry Letters 21(8): 2410-2414

Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorganic & Medicinal Chemistry Letters 20(3): 1023-1026

Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening. Journal of Medicinal Chemistry 53(6): 2661-2665

Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction. European Journal of Medicinal Chemistry 83: 174-189

Discovery and SAR studies of methionine-proline anilides as dengue virus NS2B-NS3 protease inhibitors. Bioorganic & Medicinal Chemistry Letters 23(24): 6549-6554

Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists. Bioorganic & Medicinal Chemistry 22(5): 1596-1607

Discovery and SAR study of piperidine-based derivatives as novel influenza virus inhibitors. Organic & Biomolecular Chemistry 12(40): 8048-8060

Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents. Plos One 8(2): E56475-E56475

Discovery and Structural Modification of 1-Phenyl-3-(1-phenylethyl)urea Derivatives as Inhibitors of Complement. Acs Medicinal Chemistry Letters 3(4): 317-321

Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents. Acs Medicinal Chemistry Letters 5(6): 679-684

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase. Journal of Medicinal Chemistry 51(20): 6259-6262

Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from <i>Burkholderia thailandensis</i> E264. Medchemcomm 3(8): 976-981

Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors. Antimicrobial Agents and ChemoTherapy 54(11): 4648-4657

Discovery and analysis of a novel parvovirus B19 Genotype 3 isolate in the United States. Transfusion 49(7): 1488-1492

Discovery and analysis of an active long terminal repeat-retrotransposable element in Aspergillus oryzae. Journal of General and Applied Microbiology 60(1): 1-6

Discovery and analysis of cofactor-dependent phosphoglycerate mutase homologs as novel phosphoserine phosphatases in Hydrogenobacter thermophilus. Journal of Biological Chemistry 287(15): 11934-11941

Discovery and analysis of consistent active sub-networks in cancers. Bmc Bioinformatics 14 Suppl 2: S7-S7

Discovery and analysis of microRNAs in Leymus chinensis under saline-alkali and drought stress using high-throughput sequencing. Plos One 9(11): E105417-E105417

Discovery and analysis of novel metabolic pathways for the biosynthesis of industrial chemicals: 3-hydroxypropanoate. Biotechnology and Bioengineering 106(3): 462-473

Discovery and anatomy of the arenophilic system of cuspidariid clams (Bivalvia: Anomalodesmata). Journal of Morphology 275(1): 9-16

Discovery and annotation of functional chromatin signatures in the human genome. Plos Computational Biology 5(11): E1000566-E1000566

Discovery and annotation of small proteins using genomics, proteomics, and computational approaches. Genome Research 21(4): 634-641

Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes. Chemistry Central Journal 7(1): 24-24

Discovery and application of doubly quaternized cinchona-alkaloid-based phase-transfer catalysts. Angewandte Chemie 53(32): 8375-8378

Discovery and application of insertion-deletion (INDEL) polymorphisms for QTL mapping of early life-history traits in Atlantic salmon. Bmc Genomics 11(): 156-156

Discovery and application of new bacterial strains for asymmetric synthesis of L-tert-butyl leucine in high enantioselectivity. Applied Biochemistry and Biotechnology 164(3): 376-385

Discovery and application of protein biomarkers for ovarian cancer. Current Opinion in Obstetrics & Gynecology 20(1): 9-13

Discovery and application of the Yoshida effect: nano-sized acicular materials enable penetration of bacterial cells by sliding friction force. Recent Patents on Biotechnology 1(3): 194-201

Discovery and applications of disulfide-rich cyclic peptides. Current Topics in Medicinal Chemistry 12(14): 1534-1545

Discovery and applications of the plant cyclotides. Toxicon 56(7): 1092-1102

Discovery and assembly mechanism of degenerated subunits in succinate dehydrogenase complex. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 54(15): 1965-1971

Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. Journal of the American Chemical Society 133(34): 13311-3

Discovery and basic pharmacology of erythropoiesis-stimulating agents (ESAs), including the hyperglycosylated ESA, darbepoetin alfa: an update of the rationale and clinical impact. European Journal of Clinical Pharmacology 66(4): 331-340

Discovery and bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors. Bioorganic & Medicinal Chemistry Letters 22(1): 339-342

Discovery and biochemical characterization of Plasmodium thioredoxin reductase inhibitors from an antimalarial set. Biochemistry 51(23): 4764-4771

Discovery and biological activity of 6BrCaQ as an inhibitor of the Hsp90 protein folding machinery. Chemmedchem 6(5): 804-815

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799. Bioorganic & Medicinal Chemistry Letters 21(6): 1767-1772

Discovery and biological activity of new chondramides from Chondromyces sp. Chembiochem 14(13): 1573-1580

Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate. Journal of Medicinal Chemistry 54(4): 1071-1079

Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight. Chemico-Biological Interactions 193(2): 119-128

Discovery and biological characterization of the auromomycin chromophore as an inhibitor of biofilm formation in Vibrio cholerae. Chembiochem 14(16): 2209-2215

Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid. Journal of Medicinal Chemistry 54(13): 4490-4507

Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor. Bioorganic & Medicinal Chemistry Letters 18(19): 5255-5258

Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. European Journal of Medicinal Chemistry 67: 269-279

Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists. Bioorganic & Medicinal Chemistry 20(17): 5235-5246

Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain. Journal of Medicinal Chemistry 52(10): 3366-3376

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain. Bioorganic & Medicinal Chemistry 18(22): 7816-7825

Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders. Bioorganic & Medicinal Chemistry Letters 19(18): 5310-5313

Discovery and biology of Schistosoma haematobium. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 26(2): 215-218

Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence. Journal of Medicinal Chemistry 56(17): 6761-6774

Discovery and biosynthesis of phosphonate and phosphinate natural products. Methods in Enzymology 516: 101-123

Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound. Cancer Research 70(18): 7232-7241

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1). Bioorganic & Medicinal Chemistry 21(24): 7595-7603

Discovery and characteristic of surrogate marker for Abeta42 production-possibility of diagnosis marker as pre-Alzheimer condition. Seishin Shinkeigaku Zasshi 115(3): 245-252

Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1 . Chemmedchem 10(1): 57-61

Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chemistry & Biology 18(7): 825-832

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chemistry & Biology 17(10): 1111-1121

Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist. Journal of Medicinal Chemistry 50(11): 2732-2736

Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. Journal of Medicinal Chemistry 54(13): 4781-4792

Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. Chemmedchem 8(6): 898-903

Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorganic & Medicinal Chemistry Letters 22(22): 6974-6979

Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway. Plos One 8(7): E68545-E68545

Discovery and characterization of D-phenylserine deaminase from Arthrobacter sp. TKS1. Applied Microbiology and Biotechnology 90(1): 159-172

Discovery and characterization of DNA excision repair pathways: the work of Philip Courtland Hanawalt. Journal of Biological Chemistry 285(34): E9-11

Discovery and characterization of IGFBP-mediated endocytosis in the human retinal pigment epithelial cell line ARPE-19. Experimental Eye Research 89(5): 629-637

Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors. Journal of Medicinal Chemistry 58(1): 278-293

Discovery and characterization of Melanoplus sanguinipes AKH II by combined HPLC and mass spectrometry methods. Journal of Biomolecular Techniques 13(4): 219-227

Discovery and characterization of NK13650s, naturally occurring p300-selective histone acetyltransferase inhibitors. Journal of Organic Chemistry 77(20): 9044-9052

Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorganic & Medicinal Chemistry 21(21): 6582-6591

Discovery and characterization of RecA protein of thermophilic bacterium Thermus thermophilus MAT72 phage Tt72 that increases specificity of a PCR-based DNA amplification. Journal of Biotechnology 182-183: 1-10

Discovery and characterization of [3H]8-OH-DPAT binding to HeLaS3 cells. Archives of Biochemistry and Biophysics 495(1): 14-20

Discovery and characterization of a 5-hydroxymethylfurfural oxidase from Methylovorus sp. strain MP688. Applied and Environmental Microbiology 80(3): 1082-1090

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Molecular Pharmacology 86(1): 96-105

Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chemistry & Biology 18(2): 177-186

Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans. Journal of Neurochemistry 111(1): 228-241

Discovery and characterization of a distinctive exo-1,3/1,4-{beta}-glucanase from the marine bacterium Pseudoalteromonas sp. strain BB1. Applied and Environmental Microbiology 76(20): 6760-6768

Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. Journal of the American Chemical Society 136(39): 13494-7

Discovery and characterization of a first set of polymorphic microsatellite markers in red crab (Charybdis feriatus). Journal of Genetics 92(3): E113-E115

Discovery and characterization of a fructosylated capsule polysaccharide and sialylated lipopolysaccharide in a virulent strain of Actinobacillus suis. Biochemistry and Cell Biology 89(3): 325-331

Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases. Journal of the American Chemical Society 134(22): 9428-9437

Discovery and characterization of a highly efficient enantioselective mandelonitrile hydrolase from Burkholderia cenocepacia J2315 by phylogeny-based enzymatic substrate specificity prediction. Bmc Biotechnology 13(): 14-14

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chemistry & Biology 16(4): 411-420

Discovery and characterization of a mammalian amyloid disaggregation activity. Protein Science 19(4): 836-846

Discovery and characterization of a new cell-penetrating protein. Acs Chemical Biology 8(12): 2678-2687

Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. Journal of Medicinal Chemistry 54(11): 3854-3865

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor. Bioorganic & Medicinal Chemistry Letters 22(24): 7297-7301

Discovery and characterization of a novel ATP/polyphosphate xylulokinase from a hyperthermophilic bacterium Thermotoga maritima. Journal of Industrial Microbiology & Biotechnology 40(7): 661-669

Discovery and characterization of a novel cyclic peptide that effectively inhibits ephrin binding to the EphA4 receptor and displays anti-angiogenesis activity. Plos One 8(11): E80183-E80183

Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators. Journal of Medicinal Chemistry 56(22): 9180-9191

Discovery and characterization of a novel extremely acidic bacterial N-glycanase with combined advantages of PNGase F and A. Bioscience Reports 34(6): E00149-E00149

Discovery and characterization of a novel inhibitor of CDC25B, LGH00045. Acta Pharmacologica Sinica 29(10): 1268-1274

Discovery and characterization of a novel lachrymatory factor synthase in Petiveria alliacea and its influence on alliinase-mediated formation of biologically active organosulfur compounds. Plant Physiology 151(3): 1294-1303

Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6. European Journal of Pharmacology 630(1-3): 34-41

Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions. Journal of Biological Chemistry 284(15): 9986-9993

Discovery and characterization of a photo-oxidative histidine-histidine cross-link in IgG1 antibody utilizing ¹⁸O-labeling and mass spectrometry. Analytical Chemistry 86(10): 4940-4948

Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Bioorganic & Medicinal Chemistry Letters 22(1): 363-366

Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels. Plos One 9(11): E110772-E110772

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. Journal of Biological Chemistry 284(24): 16256-16263

Discovery and characterization of a unique mycobacterial heme acquisition system. Proceedings of the National Academy of Sciences of the United States of America 108(12): 5051-5056

Discovery and characterization of alamandine: a novel component of the renin-angiotensin system. Circulation Research 112(8): 1104-1111

Discovery and characterization of an Arabidopsis thaliana N-acylphosphatidylethanolamine synthase. Journal of Biological Chemistry 284(28): 18734-18741

Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA. Journal of Biological Chemistry 285(17): 12706-12713

Discovery and characterization of an inhibitor of glucosylceramide synthase. Journal of Medicinal Chemistry 55(9): 4322-4335

Discovery and characterization of an isopeptidase that linearizes lasso peptides. Journal of the American Chemical Society 135(32): 12038-12047

Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation. Nucleic Acids Research 41(6): E67-E67

Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate. Chemmedchem 7(2): 273-280

Discovery and characterization of auxiliary proteins encoded by type 3 simian T-cell lymphotropic viruses. Journal of Virology 89(2): 931-951

Discovery and characterization of cadherin domains in Saccharophagus degradans 2-40. Journal of Bacteriology 192(4): 1066-1074

Discovery and characterization of carbamothioylacrylamides as EP<sub>2</sub> selective antagonists. Acs Medicinal Chemistry Letters 4(7): 616-621

Discovery and characterization of distinct simian pegiviruses in three wild African Old World monkey species. Plos One 9(2): E98569-E98569

Discovery and characterization of gene cassettes-containing integrons in clinical strains of Riemerella anatipestifer. Veterinary Microbiology 156(3-4): 434-438

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host & Microbe 16(4): 495-503

Discovery and characterization of heme enzymes from unsequenced bacteria: application to microbial lignin degradation. Journal of the American Chemical Society 133(45): 18006-9

Discovery and characterization of human exonic transcriptional regulatory elements. Plos One 7(9): E46098-E46098

Discovery and characterization of inhibitors of Pseudomonas aeruginosa type III secretion. Antimicrobial Agents and ChemoTherapy 54(5): 1988-1999

Discovery and characterization of ionic liquid-tolerant thermophilic cellulases from a switchgrass-adapted microbial community. Biotechnology for Biofuels 7(1): 15-15

Discovery and characterization of mammalian endogenous parvoviruses. Journal of Virology 84(24): 12628-12635

Discovery and characterization of medaka miRNA genes by next generation sequencing platform. Bmc Genomics 11 Suppl 4(): S8-S8

Discovery and characterization of miRNA during cellular senescence in bone marrow-derived human mesenchymal stem cells. Experimental Gerontology 58: 139-145

Discovery and characterization of miRNA genes in Atlantic salmon (Salmo salar) by use of a deep sequencing approach. Bmc Genomics 14(): 482-482

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. Acs Chemical Biology 6(3): 234-244

Discovery and characterization of novel allosteric FAK inhibitors. European Journal of Medicinal Chemistry 61: 49-60

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Molecular Pharmacology 75(3): 577-588

Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. Journal of Biological Chemistry 286(27): 24275-24287

Discovery and characterization of novel d-xylose-specific transporters from Neurospora crassa and Pichia stipitis. Molecular Biosystems 6(11): 2150-2156

Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate. European Journal of Medicinal Chemistry 82: 293-307

Discovery and characterization of novel lysophospholipid acyltransferases. Seikagaku. Journal of Japanese Biochemical Society 82(12): 1091-1102

Discovery and characterization of novel microRNAs during endothelial differentiation of human embryonic stem cells. Stem Cells and Development 21(11): 2049-2057

Discovery and characterization of novel mutant FLT3 kinase inhibitors. Molecular Cancer Therapeutics 9(9): 2468-2477

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. Journal of Medicinal Chemistry 57(22): 9435-9446

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. Acs Chemical Neuroscience 1(2): 104-121

Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. Plos One 4(3): E4994-E4994

Discovery and characterization of nutritionally regulated genes associated with muscle growth in Atlantic salmon. Physiological Genomics 42a(2): 114-130

Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. Mabs 6(3): 774-782

Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P₁ agonists. Bioorganic & Medicinal Chemistry Letters 21(19): 6013-6018

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus. Journal of Medicinal Chemistry 57(4): 1609-1615

Discovery and characterization of potential prognostic biomarkers for dengue hemorrhagic fever. American Journal of Tropical Medicine and Hygiene 91(6): 1218-1226

Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors. Angewandte Chemie 52(19): 5171-5174

Discovery and characterization of proteins associated with aflatoxin-resistance: evaluating their potential as breeding markers. Toxins 2(4): 919-933

Discovery and characterization of pseudocyclic cystine-knot α-amylase inhibitors with high resistance to heat and proteolytic degradation. Febs Journal 281(19): 4351-4366

Discovery and characterization of silver sulfide nanoparticles in final sewage sludge products. Environmental Science & Technology 44(19): 7509-7514

Discovery and characterization of single-nucleotide polymorphisms in steelhead/rainbow trout, Oncorhynchus mykiss. Molecular Ecology Resources 11 Suppl 1: 31-49

Discovery and characterization of small molecule inhibitors of the BET family bromodomains. Journal of Medicinal Chemistry 54(11): 3827-3838

Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests. Journal of Agricultural and Food Chemistry 59(7): 2950-2957

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. Cancer Cell 24(6): 777-790

Discovery and characterization of synthetic 4'-hydroxyflavones-New CK2 inhibitors from flavone family. Bioorganic & Medicinal Chemistry 21(21): 6681-6689

Discovery and characterization of tRNAIle lysidine synthetase (TilS). Febs Letters 584(2): 272-277

Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetes. Diabetes, Obesity & Metabolism 13(1): 19-25

Discovery and characterization of terpenoid biosynthetic pathways of fungi. Methods in Enzymology 515: 83-105

Discovery and characterization of the 1918 pandemic influenza virus in historical context. Antiviral Therapy 12(4 Pt B): 581-591

Discovery and characterization of the Crustacean hyperglycemic hormone precursor related peptides (CPRP) and orcokinin neuropeptides in the sinus glands of the blue crab Callinectes sapidus using multiple tandem mass spectrometry techniques. Journal of Proteome Research 10(9): 4219-4229

Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 19(9): 2386-2391

Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei. Journal of Bacteriology 196(2): 203-209

Discovery and characterization of the first genuine avian leptin gene in the rock dove (Columba livia). Endocrinology 155(9): 3376-3384

Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. Chemistry & Biology 17(7): 725-734

Discovery and characterization of the tuberculosis drug lead ecumicin. Organic Letters 16(23): 6044-6047

Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA. Journal of Bacteriology 192(1): 242-255

Discovery and characterization of three novel synuclein genes in zebrafish. Developmental Dynamics 237(9): 2490-2495

Discovery and characterization of two Nimrod superfamily members in Anopheles gambiae. Pathogens and Global Health 107(8): 463-474

Discovery and characterization of two novel salt-tolerance genes in Puccinellia tenuiflora. International Journal of Molecular Sciences 15(9): 16469-16483

Discovery and characterization of ß-1,6-glucan inhibitors. Expert Opinion on Drug Discovery 5(8): 739-749

Discovery and classification of homeobox genes in animal genomes. Methods in Molecular Biology 1196: 3-18

Discovery and clinical application of hepatocyte growth factor. Nihon Shokakibyo Gakkai Zasshi 110(12): 2033-2041

Discovery and clinical development of targeted molecular therapeutics. Nihon Rinsho. Japanese Journal of Clinical Medicine 70 Suppl 8: 12-17

Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif. Journal of Medicinal Chemistry 53(4): 1843-1856

Discovery and collaboration for exceptional health care: Research Week 2011 celebrates research progress through partnership. Journal of Rehabilitation Research and Development 48(5): Xi-Xiv

Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents. Accounts of Chemical Research 41(1): 32-39

Discovery and comparative analysis of a novel satellite, EC137, in horses and other equids. Cytogenetic and Genome Research 144(2): 114-123

Discovery and comparative profiling of microRNAs in a sweet orange red-flesh mutant and its wild type. Bmc Genomics 11(): 246-246

Discovery and comparative profiling of microRNAs in representative monopodial bamboo (Phyllostachys edulis) and sympodial bamboo (Dendrocalamus latiflorus). Plos One 9(7): E102375-E102375

Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. Plos One 8(10): E78744-E78744

Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods. Plos One 8(10): E76399-E76399

Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis. Annals of the Rheumatic Diseases 75(1): 234-241

Discovery and confirmation of ligand binding specificities of the Schistosoma japonicum polarity protein Scribble. Plos Neglected Tropical Diseases 8(5): E2837-E2837

Discovery and cross-amplification of microsatellite polymorphisms in asterinid sea stars. Biological Bulletin 215(2): 164-172

Discovery and crystallographic structure of human apolipoprotein. Annales Pharmaceutiques Francaises 65(2): 98-107

Discovery and customized validation of antibody targets by protein arrays and indirect ELISA. Methods in Molecular Biology 1034: 373-384

Discovery and design of DNA and RNA ligase inhibitors in infectious microorganisms. Expert Opinion on Drug Discovery 4(12): 1281-1294

Discovery and design of carbohydrate-based therapeutics. Expert Opinion on Drug Discovery 5(8): 721-737

Discovery and design of cyclic peptides as dengue virus inhibitors through structure-based molecular docking. Asian Pacific Journal of Tropical Medicine 7(7): 513-516

Discovery and design of tricyclic scaffolds as protein kinase CK2 (CK2) inhibitors through a combination of shape-based virtual screening and structure-based molecular modification. Journal of Chemical Information and Modeling 53(8): 2093-2102

Discovery and development of 11C-Lu AE92686 as a radioligand for PET imaging of phosphodiesterase10A in the brain. Journal of Nuclear Medicine 55(9): 1513-1518

Discovery and development of 5-HT(₂C) receptor agonists for obesity: is there light at the end of the tunnel?. Future Medicinal Chemistry 2(12): 1761-1775

Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents. Current Medicinal Chemistry 14(19): 2033-2047

Discovery and development of DNA methylation-based biomarkers for lung cancer. Epigenomics 6(1): 59-72

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy. Current Opinion in Chemical Biology 14(3): 412-420

Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases. Journal of Medicinal Chemistry 57(12): 5023-5038

Discovery and development of N-cadherin antagonists. Cell and Tissue Research 348(2): 309-313

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action. Future Microbiology 7(7): 823-837

Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe. Current Topics in Medicinal Chemistry 9(13): 1217-1226

Discovery and development of a selective GPR40/FFAR1 agonist, fasiglifam, for treatment of type 2 diabetes mellitus. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 144(2): 59-63

Discovery and development of a small molecule library with lumazine synthase inhibitory activity. Journal of Organic Chemistry 74(15): 5123-5134

Discovery and development of an aurora kinase inhibitor clinical candidate using an image-based assay for measuring proliferation, apoptosis, and DNA content. Assay and Drug Development Technologies 7(2): 180-190

Discovery and development of anthrax lethal factor metalloproteinase inhibitors. Current Pharmaceutical Biotechnology 9(1): 24-33

Discovery and development of anti-HBV agents and their resistance. Molecules 15(9): 5878-5908

Discovery and development of anticancer agents from marine sponges: perspectives based on a chemistry-experimental therapeutics collaborative program . Journal of Experimental Therapeutics & Oncology 10(2): 119-134

Discovery and development of antisecretory drugs for treating diarrheal diseases. Clinical Gastroenterology and Hepatology 12(2): 204-209

Discovery and development of aurora kinase inhibitors as anticancer agents. Journal of Medicinal Chemistry 52(9): 2629-2651

Discovery and development of biopharmaceuticals: current issues. Current Opinion in Biotechnology 20(6): 668-672

Discovery and development of diarylpyrimidines (DAPYs) as next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Yao Xue Xue Bao 45(2): 177-183

Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors. Current Topics in Medicinal Chemistry 10(8): 828-858

Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1. Expert Opinion on Drug Discovery 8(2): 219-244

Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. Journal of Medicinal Chemistry 51(23): 7327-7343

Discovery and development of first in class antifungal caspofungin (CANCIDAS®)--a case study. Natural Product Reports 31(1): 15-34

Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Accounts of Chemical Research 41(1): 120-129

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives. Expert Opinion on Therapeutic Patents 23(8): 919-943

Discovery and development of hepatitis C virus NS5A replication complex inhibitors. Journal of Medicinal Chemistry 57(5): 1643-1672

Discovery and development of immunosuppressants for transplantation: what are the lessons for specialty medicines?. Current Opinion in Investigational Drugs 9(5): 451-454

Discovery and development of integrative biological markers for schizophrenia. Progress in Neurobiology 95(4): 686-702

Discovery and development of lantibiotics; antimicrobial agents that have significant potential for medical application. Expert Opinion on Drug Discovery 6(2): 155-170

Discovery and development of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Expert Opinion on Drug Discovery 2(10): 1301-1327

Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. Journal of Natural Products 73(3): 500-516

Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising?. Current Opinion in Pharmacology 18: 91-97

Discovery and development of orexin receptor antagonists as therapeutics for insomnia. British Journal of Pharmacology 171(2): 283-293

Discovery and development of organic super-electron-donors. Journal of Organic Chemistry 79(9): 3731-3746

Discovery and development of penicillin. Dental Record 66(8): 197-200

Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. Acs Medicinal Chemistry Letters 5(2): 205-209

Discovery and development of purine-scaffold Hsp90 inhibitors. Expert Opinion on Drug Discovery 3(1): 99-114

Discovery and development of selective PPAR gamma modulators as safe and effective antidiabetic agents. Expert Opinion on Investigational Drugs 19(4): 489-512

Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor. Journal of Medicinal Chemistry 57(5): 1673-1693

Discovery and development of small molecule SHIP phosphatase modulators. Medicinal Research Reviews 34(4): 795-824

Discovery and development of spleen tyrosine kinase (SYK) inhibitors. Journal of Medicinal Chemistry 55(8): 3614-3643

Discovery and development of the N-terminal procollagen type II (NPII) biomarker: a tool for measuring collagen type II synthesis. Osteoarthritis and Cartilage 16(12): 1494-1500

Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis. Journal of Organic Chemistry 74(15): 5297-5303

Discovery and development of the epothilones : a novel class of antineoplastic drugs. Drugs in R&d 9(1): 1-10

Discovery and development of the green fluorescent protein, GFP: the 2008 Nobel Prize. Analytical and Bioanalytical Chemistry 396(5): 1619-1622

Discovery and development of therapeutic aptamers. Annual Review of Pharmacology and Toxicology 50: 237-257

Discovery and development of therapeutic cancer vaccines. Current Opinion in Drug Discovery & Development 10(2): 185-192

Discovery and development of thiazolo[3,2-a]pyrimidinone derivatives as general inhibitors of Bcl-2 family proteins. Chemmedchem 6(5): 904-921

Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases. Pharmaceutical Research 25(8): 1751-1761

Discovery and development of veterinary antiparasitic drugs: past, present and future. Future Medicinal Chemistry 3(7): 887-896

Discovery and development of α7 nicotinic acetylcholine receptor modulators. Journal of Medicinal Chemistry 54(23): 7943-7961

Discovery and diagnostic value of a novel oncofetal protein: glypican 3. Advances in Anatomic Pathology 21(6): 450-460

Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. Journal of Medicinal Chemistry 57(14): 5893-5903

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection. Journal of Medicinal Chemistry 57(5): 1708-1729

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase. Journal of Medicinal Chemistry 57(5): 1880-1892

Discovery and early development of non-suppressed ion chromatography. Journal of Chromatographic Science 48(7): 525-532

Discovery and early development of squaraine rotaxanes. Chemical Communications: 6329-6338

Discovery and effects of Texas Solenopsis invicta virus [SINV-1 (TX5)] on red imported fire ant populations. Journal of Invertebrate Pathology 104(3): 180-185

Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from the deep-sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrobial Agents and ChemoTherapy 56(1): 110-114

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorganic & Medicinal Chemistry 19(14): 4173-4182

Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity. Journal of Medicinal Chemistry 51(19): 5897-5900

Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. Journal of Medicinal Chemistry 53(7): 2973-2985

Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochemical Pharmacology 79(5): 678-687

Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis. Journal of Medicinal Chemistry 55(2): 709-716

Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents. Drug Design, Development and Therapy 8: 373-382

Discovery and evaluation of candidate sex-determining genes and xenobiotics in the gonads of lake sturgeon (Acipenser fulvescens). Genetica 138(7): 745-756

Discovery and evaluation of efficient selenazoles with high antifungal activity against Candida spp. Medicinal Chemistry ) 11(2): 118-127

Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin. Drug Design, Development and Therapy 8: 2161-2171

Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold. Journal of Medicinal Chemistry 56(3): 832-842

Discovery and evaluation of otic cripples. Archives of Otolaryngology 45(5): 550-561

Discovery and evaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agents. Bioorganic & Medicinal Chemistry 21(11): 3058-3065

Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations. Journal of Bioinformatics and Computational Biology 9 Suppl 1: 15-35

Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 21(9): 2641-2645

Discovery and evaluation of resources. Science 179(4072): 431-431

Discovery and evaluation of selective N-type calcium channel blockers: 6-unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives. Bioorganic & Medicinal Chemistry Letters 22(11): 3639-3642

Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor . Bioorganic & Medicinal Chemistry Letters 22(8): 2738-2743

Discovery and evaluation of thiazinoquinones as anti-protozoal agents. Marine Drugs 11(9): 3472-3499

Discovery and evolution of bunyavirids in arctic phantom midges and ancient bunyavirid-like sequences in insect genomes. Journal of Virology 88(16): 8783-8794

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part I. Bioorganic & Medicinal Chemistry Letters 22(24): 7702-7706

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part II: optimising in vivo clearance. Bioorganic & Medicinal Chemistry Letters 22(24): 7707-7710

Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction. Journal of Neuroendocrinology 22(7): 716-727

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists. Bioorganic & Medicinal Chemistry Letters 20(17): 5147-5152

Discovery and expansion of gene modules by seeking isolated groups in a random graph process. Plos One 3(10): E3358-E3358

Discovery and explanation of drug-drug interactions via text mining. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing: 410-421

Discovery and exploitation of AZADO: the highly active catalyst for alcohol oxidation. Chemical & Pharmaceutical Bulletin 61(12): 1197-1213

Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks. Journal of Biological Chemistry 284(23): 15880-15893

Discovery and exploitation of novel targets by approved drugs. Journal of Clinical Oncology 32(8): 720-721

Discovery and expression analysis of alternative splicing events conserved among plant SR proteins. Molecular Biology and Evolution 31(3): 605-613

Discovery and expression profile analysis of AP2/ERF family genes from Triticum aestivum. Molecular Biology Reports 38(2): 745-753

Discovery and extensive in vitro evaluations of NK-HDAC-1: a chiral histone deacetylase inhibitor as a promising lead. Journal of Medicinal Chemistry 55(7): 3066-3075

Discovery and follow-up of a lead-poisoning outbreak in a shantytown of Le Port, Reunion Island. Revue D'epidemiologie et de Sante Publique 61(4): 329-337

Discovery and full genome characterization of a new SIV lineage infecting red-tailed guenons (Cercopithecus ascanius schmidti) in Kibale National Park, Uganda. Retrovirology 11(): 55-55

Discovery and full genome characterization of two highly divergent simian immunodeficiency viruses infecting black-and-white colobus monkeys (Colobus guereza) in Kibale National Park, Uganda. Retrovirology 10(): 107-107

Discovery and functional analysis of a retinitis pigmentosa gene, C2ORF71. American Journal of Human Genetics 86(5): 686-695

Discovery and functional analysis of monoterpenoid indole alkaloid pathways in plants. Methods in Enzymology 515: 207-229

Discovery and functional analysis of new enzymes involved in isonitrile and nitrile metabolism. Seikagaku. Journal of Japanese Biochemical Society 79(10): 929-940

Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma. Plos Genetics 10(5): E1004372-E1004372

Discovery and functional assessment of gene variants in the vascular endothelial growth factor pathway. Human Mutation 35(2): 227-235

Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. British Journal of Pharmacology 158(3): 879-887

Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. Bmc Plant Biology 12(): 119-119

Discovery and functional evaluation of ciliary proteins in Tetrahymena thermophila. Methods in Enzymology 525: 265-284

Discovery and functional evaluation of diverse novel human CB(1) receptor ligands. Bioorganic & Medicinal Chemistry Letters 19(15): 4183-4190

Discovery and functional study of a novel crustacean tachykinin neuropeptide. Acs Chemical Neuroscience 2(12): 711-722

Discovery and genetic analysis of blue-eyed mutant in the white rex rabbits. Yi Chuan 35(6): 786-792

Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus. Plos One 6(9): E25619-E25619

Discovery and genomic characterization of noroviruses from a gastroenteritis outbreak in domestic cats in the US. Plos One 7(2): E32739-E32739

Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor. Bioorganic & Medicinal Chemistry Letters 23(8): 2432-2435

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization. Anti-Cancer Agents in Medicinal Chemistry 13(10): 1614-1635

Discovery and hit-to-lead optimization of novel allosteric glucokinase activators. Bioorganic & Medicinal Chemistry Letters 21(18): 5417-5422

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists. Bioorganic & Medicinal Chemistry Letters 22(5): 2052-2062

Discovery and identification of 2-phenylethyl 2,6-dihydroxybenzoate as a natural lipid-lowering lead. Planta Medica 77(18): 2047-2049

Discovery and identification of PIM-1 kinase inhibitors through a hybrid screening approach. Molecular Diversity 18(2): 335-344

Discovery and identification of a novel Ligon lintless-like mutant (Lix) similar to the Ligon lintless (Li1) in allotetraploid cotton. Tag. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik 126(4): 963-970

Discovery and identification of new non-ATP competitive FGFR1 inhibitors with therapeutic potential on non-small-cell lung cancer. Cancer Letters 344(1): 82-89

Discovery and identification of potential biomarkers of papillary thyroid carcinoma. Molecular Cancer 8(): 79-79

Discovery and identification of potential biomarkers of pediatric acute lymphoblastic leukemia. Proteome Science 7(): 7-7

Discovery and identification of sequence polymorphisms and mutations with MALDI-TOF MS. Methods in Molecular Biology 366: 287-306

Discovery and identification of serine and threonine phosphorylated proteins in activated mast cells: implications for regulation of protein synthesis in the rat basophilic leukemia mast cell line RBL-2H3. Journal of Proteome Research 8(6): 3068-3077

Discovery and identification of serum biomarkers of Wilms' tumor in mice using proteomics technology. Chinese Medical Journal 125(10): 1727-1732

Discovery and identification of serum potential biomarkers for pulmonary tuberculosis using iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics 14(2-3): 322-331

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. Journal of Translational Medicine 6(): 59-59

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors. Acs Medicinal Chemistry Letters 4(12): 1203-1207

Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist. Bioorganic & Medicinal Chemistry Letters 19(18): 5464-5468

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors. Bioorganic & Medicinal Chemistry Letters 24(17): 4215-4222

Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors. Journal of Medicinal Chemistry 55(17): 7667-7685

Discovery and in vivo evaluation of novel RGD-modified lipid-polymer hybrid nanoparticles for targeted drug delivery. International Journal of Molecular Sciences 15(10): 17565-17576

Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorganic & Medicinal Chemistry Letters 18(12): 3513-3516

Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines. Bioorganic & Medicinal Chemistry Letters 20(5): 1573-1577

Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors. Bioorganic & Medicinal Chemistry Letters 20(2): 632-635

Discovery and initial validation of α 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome. Proteomics. Clinical Applications 5(5-6): 334-342

Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM. Journal of Proteomics 78: 312-325

Discovery and innovation: the (atomic) clock is ticking. Journal of the American College of Radiology 9(8): 527-528

Discovery and integration of univariate patterns from daily individual organ-failure scores for intensive care mortality prediction. Artificial Intelligence in Medicine 43(1): 47-60

Discovery and investigation of O-xylosylation in engineered proteins containing a (GGGGS)n linker. Analytical Chemistry 85(9): 4805-4812

Discovery and investigation of anticancer ruthenium-arene Schiff-base complexes via water-promoted combinatorial three-component assembly. Journal of Medicinal Chemistry 57(14): 6043-6059

Discovery and investigation of misincorporation of serine at asparagine positions in recombinant proteins expressed in Chinese hamster ovary cells. Journal of Biological Chemistry 284(47): 32686-32694

Discovery and isolation of an acid-alcohol resistant tick (Amblyomma rotundatum) bacillus (Mycobacterium lutzi, n. sp.) captured in toad (Bufo marinus). Brasil-Medico 62(3-5): 17-19

Discovery and its optimized utilization of antibiotics. Nihon Rinsho. Japanese Journal of Clinical Medicine 65 Suppl 3: 638-641

Discovery and its significance of spawning grounds of Jinshaiasinensis from upper and middle Jinshajiang River. Dong Wu Xue Yan Jiu 34(6): 626-630

Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B. European Journal of Medicinal Chemistry 46(9): 4648-4656

Discovery and labeling of high-affinity 3,4-diarylpyrazolines as candidate radioligands for in vivo imaging of cannabinoid subtype-1 (CB1) receptors. Journal of Medicinal Chemistry 51(18): 5608-5616

Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis. Journal of Medicinal Chemistry 55(22): 9643-9653

Discovery and mapping of Brassica juncea Sdt 1 gene associated with determinate plant growth habit. Tag. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik 128(2): 235-245

Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2. Molecular Pharmacology 86(4): 358-368

Discovery and mapping of single feature polymorphisms in wheat using Affymetrix arrays. Bmc Genomics 10(): 251-251

Discovery and mass spectrometric analysis of novel splice-junction peptides using RNA-Seq. Molecular & Cellular Proteomics 12(8): 2341-2353

Discovery and measurement of an isotopically distinct source of sulfate in Earth's atmosphere. Proceedings of the National Academy of Sciences of the United States of America 105(35): 12769-12773

Discovery and mechanism of natural products as modulators of histone acetylation. Current Drug Targets 13(8): 1029-1047

Discovery and mechanism of ustekinumab: a human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders. Mabs 3(6): 535-545

Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. Journal of Medicinal Chemistry 56(3): 761-780

Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancer. Cancer Research 70(2): 842-851

Discovery and mechanistic studies of a general air-promoted metal-catalyzed aerobic N-alkylation reaction of amides and amines with alcohols. Journal of Organic Chemistry 76(14): 5759-5773

Discovery and mechanistic studies of facile N-terminal Cα-C bond cleavages in the dissociation of tyrosine-containing peptide radical cations. Journal of Physical Chemistry. B 118(16): 4273-4281

Discovery and mechanistic study of Al(III)-catalyzed transamidation of tertiary amides. Journal of the American Chemical Society 130(2): 647-654

Discovery and mechanistic study of a class of protein arginine methylation inhibitors. Journal of Medicinal Chemistry 53(16): 6028-6039

Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1. Acs Chemical Biology 8(10): 2201-2208

Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs. Veterinary Parasitology 201(3-4): 179-189

Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors. Bioorganic & Medicinal Chemistry Letters 22(14): 4619-4624

Discovery and molecular characterization of a new cryptovirus dsRNA genome from Japanese persimmon through conventional cloning and high-throughput sequencing. Virus Genes 50(1): 160-164

Discovery and molecular cloning of piscidin-5-like gene from the large yellow croaker (Larimichthys crocea). Fish & Shellfish Immunology 41(2): 417-420

Discovery and molecular docking of quinolyl-thienyl chalcones as anti-angiogenic agents targeting VEGFR-2 tyrosine kinase. Bioorganic & Medicinal Chemistry Letters 22(2): 942-944

Discovery and molecular engineering of sugar-containing natural product biosynthetic pathways in actinomycetes. Journal of Microbiology and Biotechnology 17(12): 1909-1921

Discovery and molecular function analysis of sulfur- and selenium-eliminating enzymes crucial for biosynthesis of iron-sulfur clusters and selenoproteins. Seikagaku. Journal of Japanese Biochemical Society 83(11): 1003-1015

Discovery and molecular modeling of novel 1-indolyl acetate--5-nitroimidazole targeting tubulin polymerization as antiproliferative agents. European Journal of Medicinal Chemistry 85: 341-351

Discovery and mutagenicity of a guanidinoformimine lesion as a new intermediate of the oxidative deoxyguanosine degradation pathway. Journal of the American Chemical Society 134(10): 4925-4930

Discovery and neuroprotective mechanisms of serofendic acid derived from fetal tissues. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 133(5): 257-260

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists. Bioorganic & Medicinal Chemistry Letters 23(16): 4627-4632

Discovery and optimisation of a potent and selective tertiary sulfonamide oxytocin antagonist. Bioorganic & Medicinal Chemistry Letters 19(2): 528-532

Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist. Bioorganic & Medicinal Chemistry Letters 21(1): 137-140

Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR). Bioorganic & Medicinal Chemistry Letters 18(18): 5083-5086

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists. Journal of Medicinal Chemistry 55(16): 7037-7053

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ. Journal of Medicinal Chemistry 57(15): 6513-6530

Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. Journal of Medicinal Chemistry 54(20): 7350-7362

Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. Journal of Medicinal Chemistry 55(7): 3135-3143

Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorganic & Medicinal Chemistry Letters 20(7): 2321-2325

Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. Journal of Medicinal Chemistry 56(8): 3281-3295

Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90. Journal of Medicinal Chemistry 57(23): 9832-9843

Discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel gpr119 agonists. Bioorganic & Medicinal Chemistry Letters 24(4): 1133-1137

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorganic & Medicinal Chemistry Letters 24(17): 4332-4335

Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1. Bioorganic & Medicinal Chemistry Letters 23(16): 4517-4522

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2. Journal of Medicinal Chemistry 55(13): 6176-6193

Discovery and optimization of CRTH2 and DP dual antagonists. Bioorganic & Medicinal Chemistry Letters 19(22): 6419-6423

Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration. Bioorganic & Medicinal Chemistry Letters 24(1): 288-293

Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists. Bioorganic & Medicinal Chemistry Letters 24(1): 156-160

Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 20(16): 4795-4799

Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorganic & Medicinal Chemistry Letters 20(3): 1031-1036

Discovery and optimization of a TRAIL R2 agonist for cancer therapy. Advances in Experimental Medicine and Biology 611: 101-103

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis. Bioorganic & Medicinal Chemistry Letters 21(21): 6608-6612

Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors. Bioorganic & Medicinal Chemistry Letters 20(21): 6268-6272

Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections. Bioorganic & Medicinal Chemistry 22(5): 1708-1725

Discovery and optimization of a novel Neuromedin B receptor antagonist. Bioorganic & Medicinal Chemistry Letters 19(15): 4264-4267

Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus. Bioorganic & Medicinal Chemistry Letters 22(18): 5942-5947

Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists. Journal of Medicinal Chemistry 51(16): 5019-5034

Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors. Journal of Medicinal Chemistry 56(5): 1996-2015

Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design. Journal of Medicinal Chemistry 55(21): 9069-9088

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe. Bioorganic & Medicinal Chemistry Letters 21(9): 2697-2701

Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors. Bioorganic & Medicinal Chemistry Letters 22(12): 4089-4093

Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors. Bioorganic & Medicinal Chemistry Letters 22(24): 7534-7538

Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents. Journal of Medicinal Chemistry 55(11): 5433-5445

Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. Journal of Medicinal Chemistry 55(11): 5291-5310

Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors. Journal of Medicinal Chemistry 54(6): 1789-1811

Discovery and optimization of a series of liver X receptor antagonists. Bioorganic & Medicinal Chemistry Letters 22(18): 5966-5970

Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1. Bioorganic & Medicinal Chemistry Letters 20(22): 6725-6729

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists. Bioorganic & Medicinal Chemistry Letters 22(2): 1055-1060

Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. Journal of Medicinal Chemistry 57(23): 10044-10057

Discovery and optimization of antibacterial AccC inhibitors. Bioorganic & Medicinal Chemistry Letters 19(23): 6507-6514

Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists. Bioorganic & Medicinal Chemistry Letters 23(12): 3609-3613

Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors. Bioorganic & Medicinal Chemistry Letters 22(11): 3786-3790

Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis. Journal of Medicinal Chemistry 55(13): 6047-6060

Discovery and optimization of boronic acid based inhibitors of autotaxin. Journal of Medicinal Chemistry 53(13): 4958-4967

Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. Journal of Medicinal Chemistry 52(22): 7044-7053

Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R). Bioorganic & Medicinal Chemistry Letters 19(3): 1004-1008

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors. Bioorganic & Medicinal Chemistry Letters 24(11): 2448-2452

Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. Journal of Medicinal Chemistry 55(10): 4788-4805

Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice. Journal of Medicinal Chemistry 53(4): 1741-1754

Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists. Bioorganic & Medicinal Chemistry Letters 19(21): 6237-6240

Discovery and optimization of novel 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazones as c-Met kinase inhibitors. Bioorganic & Medicinal Chemistry 21(17): 5246-5260

Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors. Bioorganic & Medicinal Chemistry Letters 22(15): 5067-5070

Discovery and optimization of novel purines as potent and selective CB2 agonists. Bioorganic & Medicinal Chemistry Letters 22(15): 4962-4966

Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorganic & Medicinal Chemistry Letters 23(23): 6228-6233

Discovery and optimization of p38 inhibitors via computer-assisted drug design. Journal of Medicinal Chemistry 50(17): 4016-4026

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors. Bioorganic & Medicinal Chemistry Letters 19(6): 1797-1801

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). Journal of Medicinal Chemistry 56(21): 8270-8279

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability. Bioorganic & Medicinal Chemistry Letters 21(13): 4036-4040

Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor. Bioorganic & Medicinal Chemistry Letters 19(20): 5945-5949

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors. Bioorganic & Medicinal Chemistry Letters 22(15): 4967-4974

Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorganic & Medicinal Chemistry Letters 19(22): 6307-6312

Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole. Bioorganic & Medicinal Chemistry Letters 23(3): 744-749

Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorganic & Medicinal Chemistry Letters 23(3): 750-756

Discovery and optimization of pyrazoline compounds as B-Raf inhibitors. Bioorganic & Medicinal Chemistry Letters 20(16): 4800-4804

Discovery and optimization of pyrazoline derivatives as promising monoamine oxidase inhibitors. Current Topics in Medicinal Chemistry 12(20): 2240-2257

Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters 18(15): 4352-4354

Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers. Journal of Medicinal Chemistry 57(3): 903-920

Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases. Bioorganic & Medicinal Chemistry 21(23): 7364-7380

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. Journal of the American Chemical Society 136(26): 9308-9319

Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics. Journal of Medicinal Chemistry 52(21): 6535-6538

Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators. Bioorganic & Medicinal Chemistry Letters 18(19): 5209-5212

Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. Journal of Medicinal Chemistry 54(14): 5229-5236

Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors. Bioorganic & Medicinal Chemistry Letters 22(1): 747-752

Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations. Molecular Biosystems 9(3): 361-374

Discovery and partial characterization of a non-LTR retrotransposon that may be associated with abdominal segment deformity disease (ASDD) in the whiteleg shrimp Penaeus (Litopenaeus) vannamei. Bmc Veterinary Research 9(): 189-189

Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor. Bioorganic & Medicinal Chemistry 19(23): 7221-7227

Discovery and pharmacological characterization of SAR707 as novel and selective small molecule inhibitor of stearoyl-CoA desaturase (SCD1). European Journal of Pharmacology 707(1-3): 140-146

Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta. Biochemical and Biophysical Research Communications 449(3): 327-331

Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. Journal of Pharmacology and Experimental Therapeutics 330(1): 268-275

Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. Bioorganic & Medicinal Chemistry Letters 19(23): 6604-6607

Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. Journal of Medicinal Chemistry 55(22): 10302-6

Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands. Journal of Medicinal Chemistry 55(22): 9446-9466

Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists. Bioorganic & Medicinal Chemistry Letters 24(18): 4598-4602

Discovery and phylogenetic analysis of novel members of class b enterotoxigenic Escherichia coli adhesive fimbriae. Journal of Clinical Microbiology 49(4): 1403-1410

Discovery and potency optimization of 2-amino-5-arylmethyl-1,3-thiazole derivatives as potential therapeutic agents for prostate cancer. Archiv der Pharmazie 342(7): 420-427

Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator. Journal of Medicinal Chemistry 57(3): 861-877

Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation. Plos One 8(12): E83380-E83380

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase. Journal of Medicinal Chemistry 57(5): 1855-1879

Discovery and preclinical development of new antibiotics. Upsala Journal of Medical Sciences 119(2): 162-169

Discovery and preclinical development of vismodegib. Expert Opinion on Drug Discovery 9(8): 969-984

Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases. Journal of Medicinal Chemistry 52(21): 6527-6530

Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs). Journal of Medicinal Chemistry 54(8): 2902-2914

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. Journal of Medicinal Chemistry 55(18): 8110-8127

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorganic & Medicinal Chemistry 20(19): 5705-5719

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Journal of Medicinal Chemistry 58(1): 419-432

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor. Bioorganic & Medicinal Chemistry Letters 18(9): 2985-2989

Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer. Plos One 5(12): E15573-E15573

Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane- 4,6-diones as platelet aggregation inhibitors. Combinatorial Chemistry & High Throughput Screening 15(7): 551-554

Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα. Bioorganic & Medicinal Chemistry 20(15): 4646-4652

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. European Journal of Medicinal Chemistry 46(7): 3058-3065

Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds. Bioorganic & Medicinal Chemistry Letters 23(2): 452-454

Discovery and prevalidation of salivary extracellular microRNA biomarkers panel for the noninvasive detection of benign and malignant parotid gland tumors. Clinical Cancer Research 19(11): 3032-3038

Discovery and process synthesis of novel 2,7-pyrrolo[2,1-f][1,2,4]triazines. Organic Letters 13(16): 4204-4207

Discovery and prospects of a novel thrombophilia: antithrombin resistance. Nihon Rinsho. Japanese Journal of Clinical Medicine 72(7): 1320-1324

Discovery and rediscoveries of Golgi cells. Journal of Physiology 588(Pt 19): 3639-3655

Discovery and refinement of muscle weight QTLs in B6 × D2 advanced intercross mice. Physiological Genomics 46(16): 571-582

Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study. Journal of Hypertension 29(1): 62-69

Discovery and research progress of endophytic bacteria in the root nodules of legumes--a review. Wei Sheng Wu Xue Bao 51(8): 1001-1006

Discovery and resolve: the Human Genetics Society of Australasia Oration 2011. Twin Research and Human Genetics 14(5): 387-392

Discovery and scientific investigation of a biological phenomenon. Voprosy Virusologii 57(4): 4-8

Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer. Molecular & Cellular Proteomics 8(4): 827-845

Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorganic & Medicinal Chemistry Letters 20(23): 6915-6919

Discovery and significance of new human T-lymphotropic viruses: HTLV-3 and HTLV-4. Expert Review of Anti-Infective Therapy 7(10): 1235-1249

Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'. Bioorganic & Medicinal Chemistry 16(15): 7193-7205

Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 19(15): 4467-4470

Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry. Journal of Molecular Biology 425(11): 1982-1998

Discovery and structural characterization of a novel glycosidase family of marine origin. Environmental Microbiology 13(5): 1253-1270

Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase. Protein Science 24(1): 20-26

Discovery and structural characterization of fucosylated oligomannosidic N-glycans in mushrooms. Journal of Biological Chemistry 286(8): 5977-5984

Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2. Bioorganic & Medicinal Chemistry 20(9): 2940-2949

Discovery and structural elucidation of the illegal azo dye Basic Red 46 in sumac spice. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 29(6): 897-907

Discovery and structural insight of a highly selective protein kinase inhibitor hit through click chemistry. Chemical Communications 48(22): 2788-2790

Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B. Bioorganic & Medicinal Chemistry Letters 20(9): 2876-2879

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation. Journal of Biological Chemistry 287(41): 34786-34800

Discovery and structure determination of the orphan enzyme isoxanthopterin deaminase. Biochemistry 49(20): 4374-4382

Discovery and structure optimization of a series of isatin derivatives as Mycobacterium tuberculosis chorismate mutase inhibitors. Chemical Biology & Drug Design 83(4): 498-506

Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening. European Journal of Medicinal Chemistry 54: 188-196

Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorganic & Medicinal Chemistry 17(20): 7174-7185

Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators. Bioorganic & Medicinal Chemistry Letters 23(5): 1398-1406

Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2. Bioorganic & Medicinal Chemistry Letters 22(13): 4358-4361

Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors. Journal of Medicinal Chemistry 54(7): 2341-2350

Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis. Journal of Medicinal Chemistry 53(11): 4412-4421

Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease. Journal of Medicinal Chemistry 52(2): 336-346

Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists. Bioorganic & Medicinal Chemistry Letters 20(20): 6103-6107

Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors. Journal of Medicinal Chemistry 57(13): 5579-5601

Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. Journal of Medicinal Chemistry 55(3): 1021-1046

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents. Bioorganic & Medicinal Chemistry 21(7): 1628-1642

Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists. Bioorganic & Medicinal Chemistry Letters 17(12): 3473-3479

Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase. Bioorganic & Medicinal Chemistry 22(21): 5988-6003

Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists. Bioorganic & Medicinal Chemistry 17(1): 119-132

Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters 23(21): 5870-5873

Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators. Bioorganic & Medicinal Chemistry Letters 19(19): 5531-5538

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor. Bioorganic & Medicinal Chemistry Letters 20(17): 5080-5084

Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. European Journal of Medicinal Chemistry 65: 403-414

Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). Journal of Medicinal Chemistry 54(15): 5403-5413

Discovery and structure-activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists. Bioorganic & Medicinal Chemistry Letters 17(20): 5573-5576

Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorganic & Medicinal Chemistry Letters 19(10): 2674-2678

Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters 24(15): 3403-3406

Discovery and structure-activity relationships of pyrrolone antimalarials. Journal of Medicinal Chemistry 56(7): 2975-2990

Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction. Bioorganic & Medicinal Chemistry Letters 23(5): 1253-1256

Discovery and structure-activity relationships of trisubstituted pyrimidines/pyridines as novel calcium-sensing receptor antagonists. Journal of Medicinal Chemistry 52(4): 1204-1208

Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists. Bioorganic & Medicinal Chemistry Letters 22(15): 4951-4954

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors. Bioorganic & Medicinal Chemistry Letters 24(6): 1581-1588

Discovery and structure-based optimization of adenain inhibitors. Acs Medicinal Chemistry Letters 5(8): 937-941

Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold. Bioorganic & Medicinal Chemistry Letters 19(13): 3682-3685

Discovery and study of cutaneous leishmaniasis in Karamay of Xinjiang, West China. Infectious Diseases of Poverty 2(1): 20-20

Discovery and syntheses of "superbug challengers"-platensimycin and platencin. Chemistry, An Asian Journal 5(4): 668-703

Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 20(23): 7137-7141

Discovery and synthesis of a new bis(thiourea)-Pd pincer guided by ESI-MS/MS. Journal of Mass Spectrometry 43(4): 542-546

Discovery and synthesis of a new class of opioid ligand having a 3-azabicyclo[3.1.0]hexane core. An example of a 'magic methyl' giving a 35-fold improvement in binding. Bioorganic & Medicinal Chemistry Letters 21(15): 4608-4611

Discovery and synthesis of a novel series of potent, selective inhibitors of the PI3Kα: 2-alkyl-chromeno[4,3-c]pyrazol-4(2H)-one derivatives. Organic & Biomolecular Chemistry 12(45): 9157-9165

Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors. Journal of Medicinal Chemistry 55(5): 1978-1998

Discovery and synthesis of namalide reveals a new anabaenopeptin scaffold and peptidase inhibitor. Journal of Medicinal Chemistry 55(2): 735-742

Discovery and synthesis of new UV-induced intrastrand C(4-8)G and G(8-4)C photolesions. Journal of the American Chemical Society 133(14): 5186-5189

Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents. Bioorganic & Medicinal Chemistry Letters 21(7): 1937-1941

Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors. Bioorganic & Medicinal Chemistry Letters 23(10): 3059-3063

Discovery and synthesis of novel allylthioaralkylthiopyridazines: their antiproliferative activity against MCF-7 and Hep3B cells. Archives of Pharmacal Research 38(5): 791-800

Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus. Bioorganic & Medicinal Chemistry Letters 23(20): 5575-5577

Discovery and synthesis of novel luteolin derivatives as DAT agonists. Bioorganic & Medicinal Chemistry 18(22): 7842-7848

Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents. Bioorganic & Medicinal Chemistry Letters 21(22): 6709-6713

Discovery and synthetic applications of novel silicon-carbon bond cleavage reactions based on the coordination number change of organosilicon compounds. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 84(5): 123-133

Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment. Journal of the American Chemical Society 135(47): 17906-17912

Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis. Angewandte Chemie 51(22): 5447-5451

Discovery and targeted LC-MS/MS of purified polerovirus reveals differences in the virus-host interactome associated with altered aphid transmission. Plos One 7(10): E48177-E48177

Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor. Cancer Letters 349(1): 45-50

Discovery and therapeutic potential of kinin receptor antagonists. Expert Opinion on Drug Discovery 7(12): 1129-1148

Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from Actinopolymorpha rutilus. Organic Letters 12(15): 3525-3527

Discovery and use of efficient biomarkers for objective disease state assessment in Alzheimer's disease. Conference Proceedings 2010: 2886-2889

Discovery and uses of pegvisomant: a growth hormone antagonist. Endokrynologia Polska 58(4): 322-329

Discovery and utilization of biocatalysts for chiral synthesis: an overview of Chinese scientists' research and development. Advances in Biochemical Engineering/Biotechnology 113: 1-31

Discovery and utilization of favorable genes in wild rice. Yi Chuan 30(11): 1397-1405

Discovery and validation of Barrett's esophagus microRNA transcriptome by next generation sequencing. Plos One 8(1): E54240-E54240

Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes. Plos One 8(8): E68439-E68439

Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity. Molecules 17(10): 12206-12224

Discovery and validation of a molecular signature for the noninvasive diagnosis of human renal allograft fibrosis. Transplantation 93(11): 1136-1146

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. Plos One 8(6): E65779-E65779

Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy. Plos One 8(6): E66855-E66855

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). Journal of Medicinal Chemistry 52(21): 6919-6925

Discovery and validation of an INflammatory PROtein-driven GAstric cancer Signature (INPROGAS) using antibody microarray-based oncoproteomics. Oncotarget 5(7): 1942-1954

Discovery and validation of biomarkers to guide clinical management of pneumonia in African children. Clinical Infectious Diseases 58(12): 1707-1715

Discovery and validation of breast cancer early detection biomarkers in preclinical samples. Hormones & Cancer 2(2): 125-131

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Critical Care 17(1): R25-R25

Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution. Proceedings of the National Academy of Sciences of the United States of America 106(40): 17235-17240

Discovery and validation of gene-linked diagnostic SNP markers for assessing hybridization between Largemouth bass (Micropterus salmoides) and Florida bass (M. floridanus). Molecular Ecology Resources 15(2): 395-404

Discovery and validation of genic single nucleotide polymorphisms in the Pacific oyster Crassostrea gigas. Molecular Ecology Resources 15(1): 123-135

Discovery and validation of methylation markers for endometrial cancer. International Journal of Cancer 135(8): 1860-1868

Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testing. Plos One 7(1): E29059-E29059

Discovery and validation of new antitubercular compounds as potential drug leads and probes. Tuberculosis 89(5): 331-333

Discovery and validation of new molecular targets in treating dyslipidemia: the role of human genetics. Trends in Cardiovascular Medicine 19(6): 195-201

Discovery and validation of new potential biomarkers for early detection of colon cancer. Plos One 9(9): E106748-E106748

Discovery and validation of novel and distinct RNA regulators for ribosomal protein S15 in diverse bacterial phyla. Bmc Genomics 15(): 657-657

Discovery and validation of novel expression signature for postcystectomy recurrence in high-risk bladder cancer. Journal of the National Cancer Institute 106(11): -

Discovery and validation of novel microRNAs in Sjögren's syndrome salivary glands. Clinical and Experimental Rheumatology 32(5): 761-762

Discovery and validation of novel peptide agonists for G-protein-coupled receptors. Journal of Biological Chemistry 283(50): 34643-9

Discovery and validation of ovarian cancer biomarkers utilizing high density antibody microarrays. Cancer Biomarkers 8(4-5): 293-307

Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling. World Journal of Gastroenterology 17(13): 1710-1717

Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects. Proceedings of the National Academy of Sciences of the United States of America 109(37): E2476-E2485

Discovery and validation of urinary biomarkers for detection of renal cell carcinoma. Journal of Proteomics 98(): 44-58

Discovery and validation of urinary biomarkers for prostate cancer. Proteomics. Clinical Applications 2(4): 556-570

Discovery and validation of urinary exposure markers for different plant foods by untargeted metabolomics. Analytical and Bioanalytical Chemistry 406(7): 1829-1844

Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans. Hepatology 60(4): 1291-1301

Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Annals of Emergency Medicine 55(1): 62-70.E4

Discovery and verification of amyotrophic lateral sclerosis biomarkers by proteomics. Muscle & Nerve 42(1): 104-111

Discovery and verification of gelsolin as a potential biomarker of colorectal adenocarcinoma in the Chinese population: Examining differential protein expression using an iTRAQ labelling-based proteomics approach. Canadian Journal of Gastroenterology 26(1): 41-47

Discovery and verification of matrix gla protein, a TNM staging and prognosis-related biomarker for gastric cancer. Zhonghua Bing Li Xue Za Zhi 39(7): 436-441

Discovery and verification of osteopontin and Beta-2-microglobulin as promising markers for staging human African trypanosomiasis. Molecular & Cellular Proteomics 9(12): 2783-2795

Discovery and verification of protein differences between Er positive/Her2/neu negative breast tumor tissue and matched adjacent normal breast tissue. Breast Cancer Research and Treatment 124(2): 297-305

Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis. Nucleic Acids Research 42(3): E17-E17

Discovery and widespread occurrence of polyhalogenated 1,1'-dimethyl-2,2'-bipyrroles (PDBPs) in marine biota. Environmental Pollution 178: 329-335

Discovery approaches to UPR in athero-susceptible endothelium in vivo. Methods in Enzymology 489: 109-126

Discovery at the bedside. Annals of Internal Medicine 155(9): 643-643

Discovery bioanalysis. Foreward. Bioanalysis 4(9): 983-984

Discovery biotherapeutics bioanalysis: challenges and possible solutions. Bioanalysis 4(9): 1003-1007

Discovery by a proteomic approach of possible early biomarkers of drug-induced nephrotoxicity in medication-overuse headache. Journal of Headache and Pain 14(): 6-6

Discovery by decree. Science 208(4442): 377-377

Discovery contests 'unsavoury' findings. South African Medical Journal 97(1): 17-19

Discovery dominance tradeoff: the case of Pheidole subarmata and Solenopsis geminata (Hymenoptera: Formicidae) in neotropical pastures. Environmental Entomology 40(5): 999-1006

Discovery elbow system: 2- to 5-year results in distal humerus fractures and posttraumatic conditions: a prospective study on 24 patients. Journal of Hand Surgery 39(9): 1746-1756

Discovery fit-for-purpose ligand-binding PK assays: what's really important?. Bioanalysis 5(12): 1463-1466

Discovery health premier rate. South African Medical Journal 97(8): 548-548

Discovery heralds new approach to the treatment of cystic fibrosis. Journal of Medicinal Chemistry 57(23): 9774-9775

Discovery history and clinical development of mirabegron for the treatment of overactive bladder and urinary incontinence. Expert Opinion on Drug Discovery 9(4): 433-448

Discovery in context: leveraging multidimensional glioblastoma datasets to identify targetable regulatory networks. Cancer Discovery 2(8): 676-678

Discovery in genetic skin disease: the impact of high throughput genetic technologies. Genes 5(3): 615-634

Discovery in optometry: Borish Awardees' perspectives. Optometry and Vision Science 87(4): 223-224

Discovery in the lab: Plato's paradox and Delbrück's principle of limited sloppiness. Faseb Journal 23(1): 7-9

Discovery libraries targeting the major enzyme classes: the serine hydrolases. Bioorganic & Medicinal Chemistry Letters 24(16): 3807-3813

Discovery mechanisms for the sensor web. Sensors 9(4): 2661-2681

Discovery methodology for the development of direct factor VIIa inhibitors. Expert Opinion on Drug Discovery 9(8): 859-872

Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorganic & Medicinal Chemistry Letters 23(16): 4562-4566

Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile. Bioorganic & Medicinal Chemistry Letters 21(9): 2626-2630

Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I(Kur) inhibitor. Journal of Medicinal Chemistry 55(7): 3036-3048

Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. Journal of Medicinal Chemistry 54(19): 6734-6750

Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain. Bioorganic & Medicinal Chemistry Letters 17(20): 5558-5562

Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties. Journal of Medicinal Chemistry 51(15): 4751-4764

Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. Journal of Medicinal Chemistry 57(11): 4720-4744

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator. Bioorganic & Medicinal Chemistry Letters 23(5): 1249-1252

Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity. Bioorganic & Medicinal Chemistry Letters 24(5): 1303-1306

Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors. Journal of Medicinal Chemistry 54(8): 2839-2863

Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. Journal of Medicinal Chemistry 53(16): 5956-5969

Discovery of (2-fluoro-benzyl)-(2-methyl-2-phenethyl-2H-chromen-6-yl)-amine (KRH-102140) as an orally active 5-lipoxygenase inhibitor with activity in murine inflammation models. Pharmacology 87(1-2): 49-55

Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. Journal of Medicinal Chemistry 54(13): 4694-4720

Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume. Journal of Medicinal Chemistry 52(13): 3846-3854

Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor. Journal of Medicinal Chemistry 55(17): 7480-7501

Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. Journal of Medicinal Chemistry 58(1): 376-400

Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. Journal of Medicinal Chemistry 55(22): 9793-9809

Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation. Journal of Medicinal Chemistry 52(4): 908-911

Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD. Bioorganic & Medicinal Chemistry Letters 19(16): 4560-4562

Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. Journal of Medicinal Chemistry 53(16): 5979-6002

Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine. Journal of Medicinal Chemistry 55(23): 10644-10651

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells. Bioorganic & Medicinal Chemistry Letters 24(16): 3748-3752

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. Journal of Medicinal Chemistry 54(1): 289-301

Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: synthesis, structure-activity relationships, and biological activities. Journal of Medicinal Chemistry 57(6): 2275-2291

Discovery of (E)-5-(benzylideneamino)-1H-benzo[d]imidazol-2(3H)-one derivatives as inhibitors for PTK6. Bioorganic & Medicinal Chemistry Letters 24(19): 4659-4663

Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). Journal of Medicinal Chemistry 56(12): 5208-5212

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. Journal of Medicinal Chemistry 57(17): 7412-7424

Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. Journal of Medicinal Chemistry 56(6): 2568-2580

Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. Journal of Medicinal Chemistry 51(16): 4858-4861

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch. Journal of Medicinal Chemistry 56(13): 5261-5274

Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor. Journal of Medicinal Chemistry 52(5): 1255-1258

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery. Bioorganic & Medicinal Chemistry Letters 23(11): 3157-3161

Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer. Journal of Medicinal Chemistry 57(18): 7577-7589

Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters 17(14): 4006-4011

Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). Journal of Medicinal Chemistry 57(23): 10192-7

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. Journal of Medicinal Chemistry 55(3): 1318-1333

Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor. Journal of Medicinal Chemistry 52(6): 1522-1524

Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain. Bioorganic & Medicinal Chemistry Letters 23(22): 6188-6191

Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. Journal of Medicinal Chemistry 53(1): 273-281

Discovery of (hemi-) cellulase genes in a metagenomic library from a biogas digester using 454 pyrosequencing. Applied Microbiology and Biotechnology 97(18): 8173-8182

Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay. Bioorganic & Medicinal Chemistry Letters 18(21): 5725-5728

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorganic & Medicinal Chemistry Letters 20(2): 576-580

Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. Journal of Medicinal Chemistry 53(3): 1086-1097

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization. Bioorganic & Medicinal Chemistry 15(10): 3390-3412

Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture. Bioorganic & Medicinal Chemistry Letters 21(16): 4879-4883

Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design. Journal of Medicinal Chemistry 55(5): 1898-1903

Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression. Bioorganic & Medicinal Chemistry Letters 24(6): 1532-1537

Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor. Acs Medicinal Chemistry Letters 3(3): 232-237

Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating hormone receptor 1 (MCH-R1) antagonists. Bioorganic & Medicinal Chemistry Letters 18(17): 4859-4863

Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. Journal of Medicinal Chemistry 50(17): 3973-3975

Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor. Journal of Medicinal Chemistry 55(5): 2388-2405

Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. Journal of Medicinal Chemistry 51(20): 6471-6477

Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor. Acs Chemical Neuroscience 1(12): 788-795

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters 23(12): 3584-3588

Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist. Chemmedchem 5(9): 1439-1443

Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice. Journal of Medicinal Chemistry 56(24): 9920-9933

Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor. Bioorganic & Medicinal Chemistry Letters 21(1): 520-523

Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist. Journal of Medicinal Chemistry 53(23): 8228-8240

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. Journal of Medicinal Chemistry 53(19): 7146-7155

Discovery of 1-(β-amino substituted-β-alanyl)-N,N-dimethylindoline-2-carboxamides as novel nonpeptide antagonists of nociceptin/orphanin FQ receptor: efficient design, synthesis, and structure-activity relationship studies. European Journal of Medicinal Chemistry 55: 228-242

Discovery of 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: integrated drug-design and structure-activity relationships for orally potent, metabolically stable and potential-risk reduced novel non-peptide nociceptin/orphanin FQ receptor agonist as antianxiety drug. Chemical Biology & Drug Design 74(4): 369-381

Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. Journal of Medicinal Chemistry 54(9): 3206-3221

Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia. Journal of Medicinal Chemistry 50(22): 5249-5252

Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. Journal of Medicinal Chemistry 57(22): 9627-9643

Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met. Journal of Medicinal Chemistry 56(6): 2294-2310

Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia. Journal of Medicinal Chemistry 53(5): 1923-1936

Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain. Journal of Medicinal Chemistry 52(19): 5785-5788

Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors. Bioorganic & Medicinal Chemistry Letters 22(16): 5169-5173

Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. Journal of Medicinal Chemistry 52(2): 234-237

Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. Journal of Medicinal Chemistry 54(20): 7334-7349

Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors. Bioorganic & Medicinal Chemistry Letters 21(21): 6264-6269

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I). European Journal of Medicinal Chemistry 81: 89-94

Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy. Bioorganic & Medicinal Chemistry Letters 24(12): 2648-2650

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure-activity relationships of the 4-, 5-, 6-, 7- and 8-positions. Bioorganic & Medicinal Chemistry Letters 19(13): 3481-3484

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions. Bioorganic & Medicinal Chemistry Letters 18(23): 6259-6264

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor. Journal of Medicinal Chemistry 57(15): 6495-6512

Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors. Journal of Medicinal Chemistry 57(1): 144-158

Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases. Bioorganic & Medicinal Chemistry Letters 24(2): 565-570

Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor. Journal of Medicinal Chemistry 54(14): 4998-5012

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693. Chemmedchem 9(5): 973-983

Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase. Bioorganic & Medicinal Chemistry 18(24): 8457-8462

Discovery of 1H-indole-2-carboxamides as novel inhibitors of the androgen receptor binding function 3 (BF3). Journal of Medicinal Chemistry 57(15): 6867-6872

Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists. Bioorganic & Medicinal Chemistry Letters 22(20): 6454-6459

Discovery of 2'-hydroxychalcones as autophagy inducer in A549 lung cancer cells. Organic & Biomolecular Chemistry 12(19): 3062-3070

Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors. Bioorganic & Medicinal Chemistry Letters 21(8): 2394-2399

Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs). Bioorganic & Medicinal Chemistry Letters 23(24): 6620-6624

Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension. Bioorganic & Medicinal Chemistry Letters 23(21): 5975-5979

Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators. Bioorganic & Medicinal Chemistry Letters 23(11): 3358-3363

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP(1) receptor antagonists for treatment of overactive bladder by core structure replacement. Bioorganic & Medicinal Chemistry Letters 24(5): 1327-1333

Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound . Chemmedchem 7(3): 406-414

Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. Journal of Medicinal Chemistry 52(9): 2652-2655

Discovery of 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (perampanel): a novel, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist. Journal of Medicinal Chemistry 55(23): 10584-10600

Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist. Bioorganic & Medicinal Chemistry 18(17): 6377-6388

Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. Journal of Medicinal Chemistry 54(20): 7385-7396

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors. Bioorganic & Medicinal Chemistry 17(7): 2712-2717

Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. Journal of Medicinal Chemistry 53(24): 8663-8678

Discovery of 2-(alpha-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS. Bioorganic & Medicinal Chemistry Letters 19(4): 1206-1209

Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors. Journal of Medicinal Chemistry 57(23): 9844-9854

Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. Journal of Medicinal Chemistry 56(4): 1704-1714

Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors. Acs Medicinal Chemistry Letters 3(10): 793-798

Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. Acs Medicinal Chemistry Letters 5(10): 1114-1118

Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. Journal of Medicinal Chemistry 50(11): 2597-2600

Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury. Journal of Medicinal Chemistry 53(16): 6003-6017

Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia. Journal of Medicinal Chemistry 57(10): 3912-3923

Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2. Journal of Medicinal Chemistry 57(20): 8378-8397

Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice. Journal of Medicinal Chemistry 52(14): 4496-4510

Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters. Chemical Communications 48(16): 2252-2254

Discovery of 2-aminoimidazopyridine adenosine A(2A) receptor antagonists. Bioorganic & Medicinal Chemistry Letters 20(22): 6845-6849

Discovery of 2-aminothiazoles as potent antiprion compounds. Journal of Virology 84(7): 3408-3412

Discovery of 2-aryl-8-hydroxy (or methoxy)-isoquinolin-1(2H)-ones as novel EGFR inhibitor by scaffold hopping. Bioorganic & Medicinal Chemistry 21(22): 6956-6964

Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy. Journal of Medicinal Chemistry 54(9): 3241-3250

Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorganic & Medicinal Chemistry Letters 20(1): 375-379

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist. Bioorganic & Medicinal Chemistry Letters 20(10): 3107-3111

Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity. Journal of Medicinal Chemistry 51(15): 4771-4779

Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action. European Journal of Medicinal Chemistry 78: 35-42

Discovery of 2-methoxy-3-phenylsulfonamino-5-(quinazolin-6-yl or quinolin-6-yl)benzamides as novel PI3K inhibitors and anticancer agents by bioisostere. European Journal of Medicinal Chemistry 75: 96-105

Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor. Bioorganic & Medicinal Chemistry 21(17): 5261-5270

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters 23(23): 6447-6454

Discovery of 2-naphthoic acid monooxygenases by genome mining and their use as biocatalysts. Chemsuschem 2(7): 645-649

Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation. European Journal of Medicinal Chemistry 78: 431-441

Discovery of 2-phenyl-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)acetamide derivatives as apoptosis inducers via the caspase pathway with potential anticancer activity. Archiv der Pharmazie 346(11): 812-818

Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents. Bioorganic & Medicinal Chemistry Letters 24(2): 458-461

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays. Bioorganic & Medicinal Chemistry 22(6): 1863-1872

Discovery of 2-pyridylureas as glucokinase activators. Journal of Medicinal Chemistry 57(19): 8180-8186

Discovery of 2-substituted benzoxazole carboxamides as 5-HT3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 20(22): 6538-6541

Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors. Bioorganic & Medicinal Chemistry Letters 20(8): 2644-2647

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. Journal of Medicinal Chemistry 56(11): 4597-4610

Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. Journal of Medicinal Chemistry 52(22): 7170-7185

Discovery of 229Rn and the structure of the heaviest Rn and Ra isotopes from Penning-trap mass measurements. Physical Review Letters 102(11): 112501-112501

Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004. Chemistry & Biology 17(3): 296-309

Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. Journal of Medicinal Chemistry 50(18): 4279-4294

Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents. European Journal of Medicinal Chemistry 63: 435-443

Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters 19(18): 5314-5320

Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists. Acs Medicinal Chemistry Letters 4(11): 1031-1036

Discovery of 3,4-diaminocyclobut-3-ene-1,2-dione-based CXCR2 receptor antagonists for the treatment of inflammatory disorders. Current Topics in Medicinal Chemistry 10(13): 1339-1350

Discovery of 3,4-dihydropyrimidin-2(1H)-ones with inhibitory activity against HIV-1 replication. Bioorganic & Medicinal Chemistry Letters 22(5): 2119-2124

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors. Acs Medicinal Chemistry Letters 2(5): 379-384

Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase. Bioorganic & Medicinal Chemistry Letters 19(11): 3136-3140

Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorganic & Medicinal Chemistry Letters 20(2): 640-643

Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat. Bioorganic & Medicinal Chemistry Letters 20(14): 4201-4205

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes. Journal of Medicinal Chemistry 52(20): 6193-6196

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. Journal of Medicinal Chemistry 54(20): 7066-7083

Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways. Bioorganic & Medicinal Chemistry Letters 20(15): 4526-4530

Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected. Bioorganic & Medicinal Chemistry Letters 19(21): 6225-6229

Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production. Bioorganic & Medicinal Chemistry 18(2): 597-604

Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochemical Pharmacology 89(1): 86-98

Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus. Bioorganic & Medicinal Chemistry 22(7): 2280-2293

Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. Journal of Medicinal Chemistry 55(21): 9181-9194

Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2). Bioorganic & Medicinal Chemistry Letters 24(2): 515-519

Discovery of 3-Arylcoumarin-tetracyclic Tacrine Hybrids as Multifunctional Agents against Parkinson's Disease. Acs Medicinal Chemistry Letters 5(10): 1099-1103

Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant. Journal of Medicinal Chemistry 53(12): 4701-4719

Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry 16(19): 8988-8998

Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. Journal of Medicinal Chemistry 55(22): 10229-10240

Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists. Bioorganic & Medicinal Chemistry Letters 24(13): 2949-2953

Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. Journal of Medicinal Chemistry 52(24): 7962-7965

Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor. Bioorganic & Medicinal Chemistry Letters 21(7): 1991-1996

Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 19(15): 4410-4415

Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer. Bioorganic & Medicinal Chemistry Letters 22(2): 1230-1236

Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor. Journal of Medicinal Chemistry 55(20): 8770-8789

Discovery of 3-formyl-tyrosine metabolites from Pseudoalteromonas tunicata through heterologous expression. Journal of the American Chemical Society 132(3): 926-927

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorganic & Medicinal Chemistry 21(11): 2856-2867

Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists. Acs Chemical Neuroscience 2(7): 352-362

Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses. Journal of Medicinal Chemistry 51(20): 6503-6511

Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases. Journal of Medicinal Chemistry 52(21): 6621-6636

Discovery of 3H-imidazo[4,5-b]pyridines as potent c-Met kinase inhibitors: design, synthesis, and biological evaluation. Chemmedchem 7(6): 1057-1070

Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorganic & Medicinal Chemistry 20(19): 5864-5883

Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. Acs Medicinal Chemistry Letters 2(5): 331-336

Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication. Bioorganic & Medicinal Chemistry Letters 22(9): 3265-3268

Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists. Acs Medicinal Chemistry Letters 1(2): 75-79

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase. Bioorganic & Medicinal Chemistry Letters 19(2): 469-473

Discovery of 4,6-substituted-(diaphenylamino)quinazolines as potent c-Src inhibitors. Organic & Biomolecular Chemistry 11(48): 8375-8386

Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease. Journal of Medicinal Chemistry 53(5): 2114-2125

Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry 52(10): 3377-3384

Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. Journal of Medicinal Chemistry 53(18): 6629-6639

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models. Journal of Medicinal Chemistry 53(3): 1222-1237

Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4. Journal of Medicinal Chemistry 52(8): 2289-2310

Discovery of 4-Aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties. Journal of Medicinal Chemistry 56(8): 3318-3329

Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. Journal of Medicinal Chemistry 53(2): 573-585

Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain. Bioorganic & Medicinal Chemistry Letters 20(12): 3760-3763

Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist. Bioorganic & Medicinal Chemistry 19(13): 4028-4042

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 23(7): 1974-1977

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors. Journal of Medicinal Chemistry 51(14): 4351-4355

Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). Journal of Medicinal Chemistry 53(5): 2239-2249

Discovery of 4-amino-2-(thio)phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: synthesis and biological evaluation. Part II. European Journal of Medicinal Chemistry 69: 191-200

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. Journal of Medicinal Chemistry 56(5): 2059-2073

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach. Bioorganic & Medicinal Chemistry Letters 21(24): 7277-7280

Discovery of 4-aminoquinazoline--urea derivatives as Aurora kinase inhibitors with antiproliferative activity. Bioorganic & Medicinal Chemistry 22(21): 5813-5823

Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorganic & Medicinal Chemistry Letters 24(8): 1948-1951

Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers. Bioorganic & Medicinal Chemistry Letters 19(13): 3536-3540

Discovery of 4-anilinofuro[2,3-b]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers. Journal of Medicinal Chemistry 54(13): 4446-4461

Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Bioorganic & Medicinal Chemistry Letters 18(20): 5571-5575

Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novel vascular disrupting agents. Anti-Cancer Agents in Medicinal Chemistry 9(4): 437-456

Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents. Journal of Medicinal Chemistry 57(14): 6150-6164

Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties. Journal of Medicinal Chemistry 57(10): 4098-4110

Discovery of 4-benzylamino-substituted α-carbolines as a novel class of receptor tyrosine kinase inhibitors. Chemmedchem 6(1): 63-72

Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters 19(21): 6157-6160

Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors. Bioorganic & Medicinal Chemistry Letters 22(5): 1944-1948

Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. Journal of Medicinal Chemistry 52(24): 8010-8024

Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation. Bioorganic & Medicinal Chemistry Letters 22(21): 6665-6670

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorganic & Medicinal Chemistry Letters 22(21): 6656-6660

Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorganic & Medicinal Chemistry Letters 23(2): 569-573

Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. Journal of Medicinal Chemistry 52(6): 1701-1711

Discovery of 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride as a deoxofluorinating agent with high thermal stability as well as unusual resistance to aqueous hydrolysis, and its diverse fluorination capabilities including deoxofluoro-arylsulfinylation with high stereoselectivity. Journal of the American Chemical Society 132(51): 18199-18205

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. Journal of Medicinal Chemistry 56(5): 2125-2138

Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase. Bioorganic & Medicinal Chemistry Letters 19(18): 5363-5367

Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Chemmedchem 9(2): 311-322

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2. Bioorganic & Medicinal Chemistry Letters 24(12): 2635-2639

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation. Chemmedchem 9(5): 962-972

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease. Bioorganic & Medicinal Chemistry Letters 22(14): 4613-4618

Discovery of 5-(4-hydroxyphenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide as a neuroprotectant for Alzheimer's disease by hybridization of curcumin and melatonin. Acs Chemical Neuroscience 5(8): 690-699

Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorganic & Medicinal Chemistry Letters 21(12): 3743-3748

Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. Journal of Medicinal Chemistry 51(15): 4632-4640

Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists. Bioorganic & Medicinal Chemistry Letters 20(3): 1298-1301

Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors. Journal of Medicinal Chemistry 56(3): 1064-1073

Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119. Journal of Medicinal Chemistry 57(18): 7499-7508

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. Journal of Medicinal Chemistry 54(1): 262-276

Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries. Bioorganic & Medicinal Chemistry Letters 23(5): 1407-1411

Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity. Journal of Medicinal Chemistry 56(24): 10016-10032

Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorganic & Medicinal Chemistry Letters 20(10): 3146-3149

Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists. Journal of Medicinal Chemistry 55(24): 10972-10994

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. Journal of Medicinal Chemistry 54(7): 2255-2265

Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. Journal of Medicinal Chemistry 53(15): 5620-5628

Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). Journal of Medicinal Chemistry 52(7): 2148-2152

Discovery of 6-[4-(6-nitroxyhexanoyl)piperazin-1-yl)]-9H-purine, as pharmacological post-conditioning agent. Bioorganic & Medicinal Chemistry 20(19): 5948-5956

Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists. Bioorganic & Medicinal Chemistry 22(19): 5428-5445

Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta). Journal of Medicinal Chemistry 52(9): 3098-3102

Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases. Bioorganic & Medicinal Chemistry Letters 24(4): 1138-1143

Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 20(4): 1405-1409

Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists. Bioorganic & Medicinal Chemistry Letters 20(12): 3669-3674

Discovery of 6-deoxydapagliflozin as a highly potent sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. Medicinal Chemistry ) 10(3): 304-317

Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents. Journal of Medicinal Chemistry 57(8): 3464-3483

Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22(18): 5870-5875

Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity. European Journal of Medicinal Chemistry 46(9): 4125-4132

Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. Journal of Medicinal Chemistry 52(24): 7958-7961

Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer. Journal of Medicinal Chemistry 53(5): 2000-2009

Discovery of 7-N-piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity. Journal of Medicinal Chemistry 54(2): 655-668

Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics. Bioorganic & Medicinal Chemistry Letters 23(16): 4511-4516

Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as aurora kinase inhibitors. Chemmedchem 9(1): 217-232

Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test. Bioorganic & Medicinal Chemistry Letters 22(3): 1421-1426

Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode. Bioorganic & Medicinal Chemistry Letters 23(17): 4911-4918

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. Journal of Medicinal Chemistry 54(17): 6014-6027

Discovery of 7-methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): a potent and selective transforming growth factor-β type I receptor inhibitor as a topical drug for alopecia. Chemical & Pharmaceutical Bulletin 61(3): 286-291

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). Journal of Medicinal Chemistry 55(16): 7193-7207

Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists. Journal of Medicinal Chemistry 56(11): 4482-4496

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system. Journal of Medicinal Chemistry 57(3): 878-902

Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1. Bioorganic & Medicinal Chemistry Letters 20(19): 5847-5852

Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5). Journal of Medicinal Chemistry 57(3): 578-599

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study. Letters in Drug Design & Discovery 6(4): 298-303

Discovery of 9,10-Dihydroacridines as Novel Class of ABCB1 Inhibitors. Medicinal Chemistry ) 11(4): 329-335

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Bioorganic & Medicinal Chemistry Letters 24(16): 3928-3935

Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents. Bioorganic & Medicinal Chemistry Letters 24(16): 3936-3943

Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. Journal of Medicinal Chemistry 54(5): 1473-1480

Discovery of <i>O</i>-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. Acs Medicinal Chemistry Letters 4(2): 180-185

Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction. Expert Opinion on Drug Discovery 3(9): 1123-1143

Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A. Journal of Medicinal Chemistry 57(5): 2047-2057

Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. Acs Medicinal Chemistry Letters 3(12): 997-1002

Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease. Current Alzheimer Research 4(5): 562-567

Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. Acs Medicinal Chemistry Letters 3(9): 726-730

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. Journal of Medicinal Chemistry 57(24): 10499-10511

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development. Journal of Medicinal Chemistry 57(4): 1454-1472

Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5. Acs Medicinal Chemistry Letters 2(2): 107-112

Discovery of AMG 853, a CRTH2 and DP Dual Antagonist. Acs Medicinal Chemistry Letters 2(5): 326-330

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. Journal of Medicinal Chemistry 57(8): 3430-3449

Discovery of ATL: an odyssey in restrospect. International Journal of Hematology 94(5): 423-428

Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening. Journal of Biomolecular Screening 19(8): 1137-1146

Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. Bioorganic & Medicinal Chemistry Letters 22(1): 262-266

Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action. Acs Medicinal Chemistry Letters 5(4): 416-421

Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorganic & Medicinal Chemistry Letters 23(7): 1945-1948

Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. Journal of Biological Chemistry 287(49): 41245-41257

Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors. Acs Medicinal Chemistry Letters 4(8): 742-746

Discovery of Anas platyrhynchos avian beta-defensin 2 (Apl_AvBD2) with antibacterial and chemotactic functions. Molecular Immunology 46(10): 2029-2038

Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity. Acs Medicinal Chemistry Letters 5(6): 673-678

Discovery of Apo-A1 as a potential bladder cancer biomarker by urine proteomics and analysis. Biochemical and Biophysical Research Communications 446(4): 1047-1052

Discovery of Australian bat lyssavirus in horses poses further threats to human and animal health. Australian Veterinary Journal 92(9): N2-N2

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. Acs Medicinal Chemistry Letters 4(3): 333-337

Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. Chemmedchem 7(8): 1385-1403