+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Discovery and Evaluation of Polymorphisms in the AKT2 and AKT3 Promoter Regions for Risk of Korean Lung Cancer

, : Discovery and Evaluation of Polymorphisms in the AKT2 and AKT3 Promoter Regions for Risk of Korean Lung Cancer. Genomics & Informatics 10(3): 167-174

AKT is a signal transduction protein that plays a central role in the tumorigenesis. There are 3 mammalian isoforms of this serine/threonine protein kinase-AKT1, AKT2, and AKT3-showing a broad tissue distribution. We first discovered 2 novel polymorphisms (AKT2 -9826 C/G and AKT3 -811 A/G), and we confirmed 6 known polymorphisms (AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, AKT3 -675 A/-, and AKT3 -244 C/T) of the AKT2 and AKT3 promoter region in 24 blood samples of Korean lung cancer patients using direct sequencing. To evaluate the role of AKT2 and AKT3 polymorphisms in the risk of Korean lung cancer, genotypes of the AKT2 and AKT3 polymorphisms (AKT2 -9826 C/G, AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, and AKT3 -675 A/-) were determined in 360 lung cancer patients and 360 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the AKT2 and AKT3 promoter regions were not significantly associated with the risk of lung cancer in the Korean population. These results suggest that polymorphisms of the AKT2 and AKT3 promoter regions do not contribute to the genetic susceptibility to lung cancer in the Korean population.


PMID: 23166527

DOI: 10.5808/GI.2012.10.3.167

Other references

Malkomes, H.P., 2006: Microbiological-ecotoxicological soil investigations of two herbicidal fatty acid preparations used with high dosages in weed control. Under laboratory conditions, 2 agricultural soils were treated with different rates of 2 products based on acetic acid and pelargonic acid (nonanoic acid), as well as with a biocidal reference compound (dinitrophenol herbicide). The rates were rel...

Bendet Y.A.; Bennikova E.A.; Derevyanko D.I., 1971: The physical development of children with congenital cardiac diseases. Kardiologiya 11(6): 106-111

Wiegant, W.W.; Meyers, M.; Verkaik, N.S.; van der Burg, M.; Darroudi, F.; Romeijn, R.; Bernatowska, E.; Wolska-Kusnierz, B.; Mikoluc, B.; Jaspers, N.G.J.; Vreeken, C.; Ijspeert, H.; Esveldt-van Lange, R.E.E.; Friedl, A.A.; de Villartay, J-Pierre.; Mullenders, L.H.F.; van Dongen, J.J.M.; van Gent, D.C.; Pastink, A.; Zdzienicka, Młgorzata.Z., 2010: A novel radiosensitive SCID patient with a pronounced G(2)/M sensitivity. V(D)J rearrangement in lymphoid cells involves repair of double-strand breaks (DSBs) through non-homologous end joining (NHEJ). Defects in this process lead to increased radiosensitivity and severe combined immunodeficiency (RS-SCID). Here, a SCID...

Mishra, S.Kumari.; Mathew, G.Ani.; Paul, R.Rose.; Asif, S.Kamran.; John, M.; Varghese, A.Mathew.; Kurien, M., 2016: Endoscopic Repair of CSF Rhinorrhea: An Institutional Experience. Endoscopic repair is considered the treatment of choice in cerebrospinal fluid (CSF) rhinorrhea. The aim of our study was to analyze the etiopathogenesis of CSF rhinorrhea, the outcome of treatment and the causes of failure in a developing-country...

Anonymous, 1955: THE FATE of hydrocortisone in man. Nutrition Reviews 13(6): 164-165

McColl, K., 2000: Should non-invasive Helicobacter pylori testing replace endoscopy in investigation of dyspepsia?. Our knowledge of Helicobacter pylori infection is now changing the way in which we investigate patients presenting with dyspepsia, with noninvasive H. pylori testing replacing endoscopy. Non-invasive H. pylori testing has been shown to be useful i...

Robertson, B.R.; Pandolfi, M.; Nilsson, I.M., 1972: "Fibrinolytic capacity" in healthy volunteers as estimated from effect of venous occlusion of arms. Acta Chirurgica Scandinavica 138(5): 429-436

Blackwell Bonnie A.; Schwarcz H.P.; Porat Naomi; Thackery J.F., 1992: Electron spin resonance (ESR) dating of teeth from the Australopithecine site, Swartkrans, South Africa. Abstracts with Programs - Geological Society of America 24(4): 6

Walker, T.S.; Bais, H.P.l; Vivanco, J.M.; Halligan, K.M.; Stermitz, F.R., 2002: Profiling of non-polar secondary metabolites in root exudates of Arabidopsis thaliana A study of a dynamic interface for the comprehensive characterization of rhizospheric interactions. Plant Biology (Rockville) : 102

Schatz, L.; Hollinshead, M.B., 1967: Developmental aspects of glutathione levels in dystrophic mice. Reduced glutathione (GSH) was studied in the posterior limb skeletal muscle and in the hearts of mice with progressive hereditary muscular dystrophy and their littermate controls. After homogenization in ice-cold 5% metaphosphoric acid, utilizing...