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Dissolution determination of Shuanghuanglian capsules by HPLC analysis assisted with principal component analysis

, : Dissolution determination of Shuanghuanglian capsules by HPLC analysis assisted with principal component analysis. Zhongguo Zhong Yao Za Zhi 38(7): 985-989

To develop a quality analysis method based on self-reference principal for dissolution determination of Shuanghuanglian capsules. Dissolution of Shuanghuanglian capsules was determined by principal component analysis consociated HPLC method. The liner of regression equation was good. The average recovery rates of quality assurance samples (QA) and quality control samples (QC) were all no less than 96. 0%. Dissolution curves of Shuanghuanlian capsules of different manufacturers and different batches of the same manufacturer had obvious disparity. The method can better evaluate the dissolution conditions of Shuanghuanglian capsules. The prospect of the method is expected for assessing the dissolution of other oral solid dosage of traditional Chinese medicines.


PMID: 23847942

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