+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin

, : Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin. Diabetes Care 38(3): 376-383

This study compared the efficacy and safety of dual add-on of saxagliptin plus dapagliflozin versus saxagliptin and dapagliflozin added on alone in patients with type 2 diabetes poorly controlled with metformin. This was a double-blind trial in adults with HbA1c ≥8.0% and ≤12.0% (64-108 mmol/mol), randomized to saxagliptin (SAXA) (5 mg/day) plus dapagliflozin (DAPA) (10 mg/day; n = 179), or SAXA (5 mg/day) and placebo (n = 176), or DAPA (10 mg/day) and placebo (n = 179) on background metformin extended release (MET) ≥1,500 mg/day. Primary objective compared changes from baseline in HbA1c with SAXA+DAPA+MET versus SAXA+MET and DAPA+MET. Patients had a mean baseline HbA1c of 8.9% (74 mmol/mol), diabetes duration of 7.6 years, and a BMI of 32 kg/m(2). At week 24, the adjusted mean change from the baseline HbA1c was -1.5% (-16.1 mmol/mol) with SAXA+DAPA+MET versus -0.9% (-9.6 mmol/mol) with SAXA+MET (difference -0.59% [-6.4 mmol/mol], P < 0.0001) and -1.2% (-13.1 mmol/mol) with DAPA+MET (difference -0.27% [3.0 mmol/mol], P < 0.02). The proportion of patients achieving HbA1c <7% (53 mmol/mol) was 41% with SAXA+DAPA+MET versus 18% with SAXA+MET and 22% with DAPA+MET. Urinary and genital infections occurred in ≤1% of patients receiving SAXA+DAPA+MET. Hypoglycemia was infrequent, with no episodes of major hypoglycemia. In this first report of adding a well-tolerated combination of saxagliptin plus dapagliflozin to background metformin therapy in patients poorly controlled with metformin, greater improvements in glycemic control were obtained with triple therapy by the dual addition of saxagliptin and dapagliflozin than dual therapy with the addition of saxagliptin or dapagliflozin alone.


PMID: 25352655

DOI: 10.2337/dc14-1142

Other references

Mcglone, Ms, 1982: Modern pollen rain, Egmont National Park, New Zealand Plant communities, vegetation types. New Zealand journal of botany0(3): 253-262

Bedell, G.F.; Gebhart, E.M., 1989: Peer review. Using a group process format. Aorn Journal 50(5): 1059-61, 1063-4

Santulli, R.J.; Derian, C.K.; Darrow, A.L.; Tomko, K.A.; Eckardt, A.J.; Seiberg, M.; Scarborough, R.M.; Andrade-Gordon, P., 1995: Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Thrombin receptor activation was explored in human epidermal keratinocytes and human dermal fibroblasts, cells that are actively involved in skin tissue repair. The effects of thrombin, trypsin, and the receptor agonist peptides SFLLRN and TFRIFD...

Brown, W.D.; Taylor, M.D.; Roberts, A.D.; Oakes, T.R.; Schueller, M.J.; Holden, J.E.; Malischke, L.M.; DeJesus, O.T.; Nickles, R.J., 1999: FluoroDOPA PET shows the nondopaminergic as well as dopaminergic destinations of levodopa. Objective: To evaluate the visible and quantitative anatomic distribution of fluorine-18-labeled L-DOPA in the healthy human brain, to thereby expand the understanding of extrastriatal sites of levodopa function, and to provide a broader foundatio...

Smith, B.T.; Inglesby, T.V.; O'Toole, T., 2004: Biodefense R&D: anticipating future threats, establishing a strategic environment. Biosecurity and Bioterrorism 1(3): 193-202

Demeulenaere L.; Rottiers R.; Van Egmond J.; Lacres R., 1968: Emergency and chronic treatment of hyper ammonemia with lactulose in spontaneous paroxsymal artificially induced and chronic types of cirrhosis. Annales de l'Anesthesiologie Francaise 9(3): LIII

Anonymous, 1981: Thailand's largest underground mine. Description of the Song Toh lead-zinc mine, exploited by Karnchanaburi Exploration and Mining Co Ltd (51 percent Bhol and Sons, 49 percent Metallgesellschaft): exploitation method and schematic flow-sheet of ore treatment. Annual production: 30 ki...

Nowicka, D., 2006: Waste management: new legal regulations - part 2. Changes in the regulations governing waste management in Poland were introduced into law on 29 July 2005. This paper describes and examines those changes, including the exemptions for which certain categories of installation can apply. These categ...

Mitra A.K.; Chatterjee J.K.; Pal P.K., 1967: Problems of management of pregnancy with diabetes and allied conditions. Madhumeh (Diabetes) 8(2): 111-120

Aslanbey D., 1967: The fractures of the pelvis in cats and their treatment by osteosynthesis. Ankara Universitesi Veteriner Fakultesi Dergisi 14(4): 566-572