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E-selectin and TFPI are associated with carotid intima-media thickness in stable IHD patients: the baseline findings of the MIAMI study

, : E-selectin and TFPI are associated with carotid intima-media thickness in stable IHD patients: the baseline findings of the MIAMI study. Nutrition, Metabolism, and Cardiovascular Diseases 18(4): 320-328

MIAMI was a prospective multicenter clinical study designed to investigate the relationship between changes in carotid intima-media thickness (C-IMT) and those in the levels of circulating markers of inflammation, thrombosis and endothelial dysfunction. The study was performed in a group of stable coronary patients treated for two years with a moderate dosage of atorvastatin (20mg/day). In this paper the cross-sectional relationship between C-IMT and the same circulating markers of inflammation, thrombosis and endothelial dysfunction measured at baseline was investigated. Eighty-five subjects that had not used statins for at least two months were enrolled in the study. At time of enrollment, the levels of vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), E-selectin, interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, high-sensitivity C-reactive protein (hs-CRP), tissue factor (TF), tissue factor pathway inhibitor (TFPI), von Willebrand factor (vWF), fibrinogen, total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL), and triglycerides were measured, in parallel with C-IMT assessment. In cross-sectional analyses, markers of endothelial perturbation (i.e. E-selectin) and TFPI were more strongly correlated with arherosclerotic burden than markers of inflammation. The baseline picture in this study indicates that E-selectin and TFPI are linked with atherosclerotic burden.


PMID: 17889518

DOI: 10.1016/j.numecd.2007.01.008

Other references

Georgievskii A.B., 1972: The structure of the coeno population of haloxylon ammodendron in the southeast karakum. Botanicheskii Zhurnal (St Petersburg) 57(11): 1444-1454

Ahmad, K.; Lewis, J.J., 1961: The effects of gallamine, carbachol, nicotine, ryanodine and protoveratrine A and B upon flux of calcium-47 in frog skeletal muscle. Journal of Pharmacy and Pharmacology 13: 383-384

Hatae T.; Benedetti E.L., 1978: Mosaic structures in plasma membrane square lattice array of subunits in the cytoplasmic tubules of the lamprey chloride cell. Journal of Electron Microscopy 27(4): 381

Oatman, E.R., 1965: Effects of preblossom miticides and subsequent insecticide applications on mite populations on apple in Wisconsin. The effect of Genite 923 (2,4-dichlorophenyl benzenesulfonate), chlorbenside, and tetradifon as preblossom miticides and lead arsenate, ryania and carbaryl as insecticides on European red mite. Panonychus ulmi (Koch), two-spotted spider mite, Tetr...

Marchetti, F.; Tavani, A., 1991: Symptoms in pediatrics: vomiting and diarrhea. Rivista Dell'infermiere 10(2): 111-117

Feldman, S.R.; Trojanowska, M.; Smith, E.A.; Leroy, E.C., 1993: Differential responses of human papillary and reticular fibroblasts to growth factors. Differences in the responses to growth factors of normal fibroblasts and scleroderma fibroblasts have been demonstrated previously. Because human dermal fibroblasts are heterogeneous populations, whether known differences between papillary and ret...

Anonymous, 1969: Guide to patient care; a procedural manual. League Exchange 90: 1-113

Oman, P.W., 1938: A contribution to the classification of South American Agallian leafhoppers. Annals of the Carnegie Museum, 13: 351-460

Porstendorfer G., 1987: Deep geomagnetic sounding using variational universal fields. Pages 70-74 1987

Chen, M.; Jensen, M.; Rodermel, S., 1999: The yellow variegated mutant of Arabidopsis is plastid autonomous and delayed in chloroplast biogenesis. The yellow variegated mutant of Arabidopsis thaliana is characterized by bright-yellow true leaves that turn green- and white-sectored as leaf development proceeds. Variegation is due to the action of a nuclear recessive gene. Whereas cells in the...