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Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction


, : Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction. Plos One 6(5): E20369-E20369

Intrauterine growth restriction (IUGR) is a risk factor for cardiovascular disease in later life. Early structural and functional changes in the cardiovascular system after IUGR may contribute to its pathogenesis. We tested the hypothesis that IUGR leads to primary myocardial and vascular alterations before the onset of hypertension. A rat IUGR model of maternal protein restriction during gestation was used. Dams were fed low protein (LP; casein 8.4%) or isocaloric normal protein diet (NP; casein 17.2%). The offspring was reduced to six males per litter. Immunohistochemical and real-time PCR analyses were performed in myocardial and vascular tissue of neonates and animals at day 70 of life. In the aortas of newborn IUGR rats expression of connective tissue growth factor (CTGF) was induced 3.2-fold. At day 70 of life, the expression of collagen I was increased 5.6-fold in aortas of IUGR rats. In the hearts of neonate IUGR rats, cell proliferation was more prominent compared to controls. At day 70 the expression of osteopontin was induced 7.2-fold. A 3- to 7-fold increase in the expression of the profibrotic cytokines TGF-β and CTGF as well as of microfibrillar matrix molecules was observed. The myocardial expression and deposition of collagens was more prominent in IUGR animals compared to controls at day 70. In the low-protein diet model, IUGR leads to changes in the expression patterns of profibrotic genes and discrete structural abnormalities of vessels and hearts in adolescence, but, with the exception of CTGF, not as early as at the time of birth. Invasive and non-invasive blood pressure measurements confirmed that IUGR rats were normotensive at the time point investigated and that the changes observed occurred independently of an increased blood pressure. Hence, altered matrix composition of the vascular wall and the myocardium may predispose IUGR animals to cardiovascular disease later in life.

US$19.90

PMID: 21655297

DOI: 10.1371/journal.pone.0020369


Other references

Groetzner, P.; Weidner, C., 2010: The human vasodilator axon reflex - an exclusively peripheral phenomenon?. The effect of regional anesthesia of the brachial plexus on the size and intensity of the histamine-induced axon reflex flare (neurogenic inflammation) of the forearm and the upper arm was compared to that of the contralateral arm as control in hu...

Jackson Michael; Moskowitz Bruce M.; Rosenbaum Joe G.; Kissel Catherine, 1998: Field-dependence of AC susceptibility in titanomagnetites. AC susceptibility measurements as a function of field amplitude H (sub ac) and of frequency show a strong field dependence for a set of synthetic titanomagnetites (Fe (sub 3-x) Ti (sub x) O (sub 4) ) and for certain basalts from the SOH-1 Hawaiian...

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Langlands, J.P., 1973: Wheat as a survival ration for sheep. 1. The digestion of wheat and formaldehyde treated wheat. 1. Twenty Australian Merino wethers in metabolism cages were used in the first experiment in which the sheep had urea or no urea, untreated wheat or wheat treated with 5, 10, 15, 20 or 30% formaldehyde. Digestibility of organic matter and proporti...

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Lewinsohn, P.M., 1975: Engagement in pleasant activities and depression level. Journal of Abnormal Psychology 84(6): 729-731

Wilmoth, G., J.; Perniciaro, C., 1996: Cutaneous extravascular necrotizing granuloma (Winkelmann granuloma): Confirmation of the association with systemic disease. Background: An unusual palisading granuloma has been described in patients with immunoreactive diseases. Multiple names have been given to this lesion. Objective: Our aim was to verify whether a distinct palisading granuloma can be used as a marke...

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