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Early exposure to ethanol or red wine and long-lasting effects in aged mice. A study on nerve growth factor, brain-derived neurotrophic factor, hepatocyte growth factor, and vascular endothelial growth factor

, : Early exposure to ethanol or red wine and long-lasting effects in aged mice. A study on nerve growth factor, brain-derived neurotrophic factor, hepatocyte growth factor, and vascular endothelial growth factor. Neurobiology of Aging 33(2): 359-367

Prenatal ethanol exposure produces severe changes in brain, liver, and kidney through mechanisms involving growth factors. These molecules regulate survival, differentiation, maintenance, and connectivity of brain, liver, and kidney cells. Despite the abundant available data on the short and mid-lasting effects of ethanol intoxication, only few data show the long-lasting damage induced by early ethanol administration. The aim of this study was to investigate changes in nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF) in brain areas, liver, and kidney of 18-mo-old male mice exposed perinatally to ethanol at 11% vol or to red wine at the same ethanol concentration. The authors found that ethanol per se elevated NGF, BDNF, HGF, and VEGF measured by ELISA in brain limbic system areas. In the liver, early exposure to ethanol solution and red wine depleted BDNF and VEGF concentrations. In the kidney, red wine exposure only decreased VEGF. In conclusion, the present study shows that, in aged mice, early administration of ethanol solution induced long-lasting damage at growth factor levels in frontal cortex, hippocampus, and liver but not in kidney. Otherwise, in mice exposed to red wine, significant changes were observed in the liver and kidney but not in the hippocampus and frontal cortex. The brain differences in ethanol-induced toxicity when ethanol is administered alone or in red wine may be related to compounds with antioxidant properties present in the red wine.


PMID: 20382450

DOI: 10.1016/j.neurobiolaging.2010.03.005

Other references

Donta, I.; Karayannacos, P.E.; Boudoulas, H.; Kostakis, A.; Sechas, M.; Varonos, D.; Scalkeas, G.R., 1982: Effect of beta-adrenergic blockade on physiologic growth in the Wistar rat. The effect of propranolol (Pr) on body weight was studied in 144 Wistar rats of both sexes from weaning to 17 weeks of age. Pr was administered to 77 of these rats (chosen at random), in a dose of 100 mg/kg body weight daily. Body weights were mon...

Moccia, M.; Roviello, G.N.; Bucci, E.M.; Pedone, C.; Saviano, M., 2011: Synthesis of a l-lysine-based alternate alpha,epsilon-peptide: a novel linear polycation with nucleic acids-binding ability. A novel nucleic acid compaction device based on a positively-charged alpha,epsilon-poly-l-lysine was realized for the first time. The polycationic peptide was obtained by assembling Fmoc and Boc orthogonally protected l-lysine monomers by solid ph...

Kiselev, Aia, 1978: Aphids on annual lupine crops. Zashchita rastenii: (9) 39

Hill, D.H., 1988: Cattle and buffalo meat production in the tropics. This book is one of a series designed for students of agriculture on diploma and certificate courses at intermediate colleges, first-year agriculture students at universities, and extension workers. After an introductory chapter on world meat prod...

Silvert, M., 2016: The famous case of Alice Cooper - psychiatry in pictures. British Journal of Psychiatry 207(4): 285-285

Newiadomski, M.M., 1946: The occurrence of viruses in tumors. The author demonstrated the ability of a sarcoma virus and that of rat and mouse cancer to pass through collodion membranes and showed the presence of elementary bodies in the acellular filtrate of the Flex-Jobl strain. The origin of tumor cells f...

Alonso; Marro, 1992: Mean-field solution of a nonequilibrium random-exchange Ising-model system. Physical Review. B, Condensed Matter 45(18): 10408-10418

Olson, D.H.; Nauman, R.S.; Ellenburg, L.L.; Hansen, B.P.; Chan, S.S., 2006: Ensatina eschscholtzii nests at a managed forest site in Oregon. We sampled terrestrial salamanders in riparian and upland areas within a 40-y-old managed forest site in western Oregon. We found 303 ensatinas (0.015 animals/m2) and 14 nests (0.0007 nests/m2, 0.05 nests/ensatina) within 20,280 m2 of forested hab...

Olivero, O.A.; Blattner, W.A.; Landay, A.L.; Poirier, M.C., 2001: Telomere shortening induced by transplacental nucleoside analog exposure in primates. Journal of Human Virology 4(3): 161, May-June

Dipeolu O.O.; Akinboade O.A.; Adetunji A., 1981: Transmission of anaplasma marginale from a naturally infected wild african giant rat cricetomys gambianus to a calf in nigeria. Blood taken from an African giant rat in Nigeria, transmitted A. marginale when inoculated into a splenectomized calf. The infection of the calf was sub-clinical and the highest percentage of infected erythrocytes recorded was 6. A. marginale was...