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Early life environment, neurodevelopment and the interrelation with atopy


, : Early life environment, neurodevelopment and the interrelation with atopy. Environmental Research 110(7): 733-738

Both neurological and immunological systems are vulnerable to early life exposures. Neurological disorders and atopy have been related in animals and humans. Our main objective was to assess whether multiple exposures to early life determinants remain associated with neurodevelopment after considering the potential intermediate role of atopy. A second objective was to assess whether genes associated with atopy may inform about the potential neurotoxical mechanisms. Children were members of the AMICS birth cohort in Menorca (n=418, 87% of the recruited). General cognition was measured with the McCarthy Scales at age 4 and atopy through specific IgE at age 4 and prick test at age 6; 85 single nucleotide polymorphisms (SNPs) in 16 atopy and detoxification genes were genotyped. Among the 27 risk factors assessed, lower maternal social class, maternal smoking during pregnancy, being first born, shorter breastfeeding, higher DDT levels in cord blood, and higher indoor levels of NO2 (among the non-detoxifiers by GSTP1 polymorphism) were independently associated with poorer cognition. These associations were apparently not mediated by the relation between atopy and general cognition. Among the candidate atopic genes, variants in NQ01 (a detoxification gene) and NPRS1 (related with affective disorders like anxiety and stress management) had a significant association with general cognition (p-value<0.001). However, adjustment for the corresponding SNPs did not change the association between the early life determinants and general cognition. Multiple environmental pre-natal exposures were associated with neurodevelopment independently of their role in the immunological system. Atopic genes related to neurodevelopment suggest some potential mechanisms.

US$19.90

PMID: 20701904

DOI: 10.1016/j.envres.2010.07.005


Other references

Gego, A., 1984: Problems in agricultural mechanization in developing countries. The potential for increased production in the agricultural sector is discussed. The increased crop yields made possible by the adoption of new cultivation and harvesting techniques, irrigation, improved seed quality, chemical use and new storage a...

Benson, J.S.; Hager, T.C., 1993: The distribution, abundance and habitat of Eucalyptus dunnii (Myrtaceae) (Dunn's White Gum) in New South Wales. Eucalyptus dunnii is a tall, fast growing forest tree restricted to north-eastern NSW and south-eastern Queensland. It is phylogenetically close to Eucalyptus angophoroides which has its closest occurrences 700 km to the south. E. dunnii is a nati...

Miura, K., 1979: The structure of main vegetable. Nokei ronso = The Review of agricultural economics Hokkaido University 35(35): 69-96

James O.; Green R.; Levkoff A., 1974: Reversing acidotic hyper kalemia of acute renal shutdown by artificial hyper ventilation. Pediatric Research 8(4): 456

Qi, K.; Wang, Q.; Zheng, W.; Zhang, W.; Cui, X., 2014: Porous single-crystalline palladium nanoflowers with enriched {100} facets for highly enhanced ethanol oxidation. Palladium porous single-crystalline nanoflowers (PSNFs) with enriched high catalytic activity {100} facets were synthesized using a mild and controllable seed mediated growth method. The growth mechanism of the Pd PSNFs was investigated using time...

Bull A.W.; Bronstein J.C.; Nigro N.D., 1988: Role of essential fatty acid in azoxymethane induced colon carcinogenesis. Proceedings of the American Association for Cancer Research Annual Meeting 29: 149

Kaiser, S.; Brandt, A., 2007: Two new species of the genus Austroniscus Vanhoeffen, 1914 (Isopoda: Asellota: Nannoniscidae) from the Antarctic shelf. During the BENDEX expedition (BENthic Disturbance-EXperiment) with RV Polarstern in Antarctic summer 2003/04, species of the genus Austroniscus Vanhoeffen, 1914 were sampled from the continental shelf of the eastern Weddell Sea. Besides Austronisc...

Chen, Y.H.; Wu, W.; Yang, J.; Sui, S.F.; Sun, J.; Dierich, M.P., 1999: Antibodies against human IFN-alpha and -beta recognized the immunosuppressive domain of HIV-1 gp41 and inhibit gp41-binding to the putative cellular receptor protein p45. Sequence-comparison indicates existing sequence-similarity between receptor-binding regions of human type 1 IFNs (IFN-alpha, -beta and -omega) and HIV-1 gp41. Previous findings had suggested that the increased levels of antibodies against human IF...

Reitan, O.; Sternby, J.; Ohlin, H., 2000: Hydrodynamic properties of a new percutaneous intra-aortic axial flow pump. Cardiac intervention, myocardial infarction, or postoperative heart failure will sometimes create a need for circulatory support. For this purpose, a new, minimally invasive intra-aortic cardiac support system with a foldable propeller has been de...

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