+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Early-life seizures result in deficits in social behavior and learning

, : Early-life seizures result in deficits in social behavior and learning. Experimental Neurology 256: 74-80

Children with epilepsy show a high co-morbidity with psychiatric disorders and autism. One of the critical determinants of a child's behavioral outcome with autism and cognitive dysfunction is the age of onset of seizures. In order to examine whether seizures during postnatal days 7-11 result in learning and memory deficits and behavioral features of autism we administered the inhalant flurothyl to induce seizures in C57BL/6J mice. Mice received three seizures per day for five days starting on postnatal day 7. Parallel control groups consisted of similarly handled animals that were not exposed to flurothyl and naïve mice. Subjects were then processed through a battery of behavioral tests in adulthood: elevated-plus maze, nose-poke assay, marble burying, social partition, social chamber, fear conditioning, and Morris water maze. Mice with early-life seizures had learning and memory deficits in the training portion of the Morris water maze (p<0.05) and probe trial (p<0.01). Mice with seizures showed no differences in marble burying, the nose-poke assay, or elevated plus-maze testing compared to controls. However, they showed a significant difference in the social chamber and social partition tests. Mice with seizures during postnatal days 7-11 showed a significant decrease in social interaction in the social chamber test and had a significant impairment in social behavior in the social partition test. Together, these results indicate that early life seizures result in deficits in hippocampal-dependent memory tasks and produce long-term disruptions in social behavior.


PMID: 24685665

DOI: 10.1016/j.expneurol.2014.03.014

Other references

Ponz D.L.on M.; Dowling R.H., 1977: Clinical pharmacology of oral cheno deoxy cholic acid. Gut 18(11): A976

Gilboa, E.;, P.S.; Nehorai, A., 2013: Estimating electrical conductivity tensors of biological tissues using microelectrode arrays. Finding the electrical conductivity of tissue is highly important for understanding the tissue's structure and functioning. However, the inverse problem of inferring spatial conductivity from data is highly ill-posed and computationally inten...

Lescoeur, J.E., 1966: Thoughts on amputation stumps. Bulletin et Memoires de la Societe des Chirurgiens de Paris 56(2): 67-70

Magistretti, M., 1969: Contributo alia conoscenza dei Coleotteri termofili prealpini (Carabidi e Meloidi). Memorie del Museo Civico di Storia Naturale di Verona, 17: 227-235

Bianchi, TS., 1991: Density-dependent consumer effects on resource quality in carbonate sediments. Texas Journal of Science, 433: 283-295

Rossen, J.; Dillehay, T.D.; Ugent, D., 1996: Ancient cultigens or modern intrusions? Evaluating plant remains in an Andean case study. Journal of Archaeological Science 23(3): 391-407

Korcekova,A., 2008: ICUMSA methods for laboratory control of sugar production Method GS2/3-18 Determination of turbidity of white sugar solutions - official method. This is a Slovak translation of ICUMSA method GS2/3-18 on the determination of turbidity of white sugar, for sugars with colour not exceeding 50 IU.

Gray W.F.; Pomerantz I.H.; Ross R.D., 1972: Uv irradiation of 6 methyl 2 3 quinoxaline di thiol cyclic carbonate morestan. Journal of Heterocyclic Chemistry 9(3): 707-711

Colomer Pujol, D., 1999: Acute lymphoblastic leukemia: its clinical cure and molecular cure. Medicina Clinica 112(13): 495-496

Lee, R.Hui-Chao.; Tseng, T-Yi.; Wu, C.Yin-Chieh.; Chen, P-Yi.; Chen, M-Fang.; Kuo, J-Son.; Lee, T.Jer-Fu., 2013: Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries. Memantine, an NMDA receptor antagonist used for treatment of Alzheimer's disease (AD), is known to block the nicotinic acetylcholine receptors (nAChRs) in the central nervous system (CNS). In the present study, we examined by wire myography i...