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Effect of anatoxin-A on calcium-mediate signal system of brain tissue in mice


, : Effect of anatoxin-A on calcium-mediate signal system of brain tissue in mice. Wei Sheng Yan Jiu 36(1): 9-11

To explore the mechanism of central neurotoxity induced by anatoxin-A (ANTX-A) from the calcium-mediate signal system. Mice were administered by i.p. at different doses of ANTX-A for one month, 0.9% of sodium chloride solution was used as the control. Using fluorescence method and colorimetry method, the intracellular calcium concentration and the activity of calcineurin (CaN, PP2B) and ATPase in brain were determined. Calcium concentrations in brain were increased in 12.5, 50 and 200 microg/kg bw groups compared with the control group, the difference had statistical significance (P < 0.01). The activity of PP2B of brain in 200 microg/kg bw group was enhanced compared with the control group (P < 0.05). In all ANTX-A treated groups, the activity of Na+ -K+ -ATPase of brain in mice had no obvious changes, but the activity of Ca2+ -ATPase in 50 and 200 microg/kg bw groups were significantly reduced compared with the control group ( P < 0.05). It is suggested that calcium-mediate signal system could have important regulative action in the central neurotoxity induced by antoxin-A.

US$29.90

PMID: 17424837


Other references

Saitoh, K., 1979: A note on the haploid karyotype of the Mediterranean skipper, Gegenes nostrodamus Fabricius (Lepidoptera: Hesperiidae) from Israel. Chromosome information service: (27) 8-9

Klein, G.; Clifford, P.; Henle, G.; Henle, W.; Geering, G.; Old, L.J., 1969: EBV-associated serological patterns in a Burkitt lymphoma patient during regression and recurrence. International Journal of Cancer 4(4): 416-421

Franz, A., 2015: Atypical ECG - technical pitfalls. Deutsche Medizinische Wochenschrift 140(18): 1336-1336

Mccollum, A., 1978: Yeast power and how to keep it. Organic gardening: 25 (11) 140-143

Brosch, E., 1962: Suppurative inflammation of the inner ear, abscess of the cerebellum and thrombosis of the sigmoid sinus as a complication of chronic inflammation of the middle ear. Ceskoslovenska Otolaryngologie 11: 236-239

Díaz, E.; Jiménez, Jé.Ignacio.; Nogales, J., 2013: Aerobic degradation of aromatic compounds. Has been enriched considerably by the current omic methodologies and systems biology approaches, revealing the participation of intricate metabolic and regulatory networks. New enzymes, transporters, and specific/global regulatory systems have bee...

Kida, K.; Tanemura, K.; Sonoda, Y., 1993: Evaluation of the Anaerobic Treatment of Sewage Below 20 degree C by Novel Processes. Estimations of running costs revealed that anaerobic treatment of sewage at less than 20-ETA was more economical than aerobic treatment. An anaerobic fluidized-bed reactor (AFBR) and an upflow anaerobic sludge blanket (UASB) were applied to the an...

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Loubens, G.; Osorio, F., 1988: Observations on the fishes of the bolivian part of lake titicaca iii. basilichthys bonariensis valenciennes 1835. The Lake Titicaca pejerrey (Basilichthys bonariensis) has been introduced into Bolivia at about 1950. The genus to which it belongs is still uncertain. This fish is captured with small scale gears like superficial gillnets and small beach seines....

Lu, X.P.; Omar, R.A.; Chang, W.W., 1996: Immunocytochemical expression of the 70 kD heat shock protein in ischaemic bowel disease. Heat shock proteins (HSPs) are a family of polypeptides which are induced in response to diverse forms of cell injury including hyperthermia, anoxia, ethanol, heavy metals, and others, with a presumably protective function. Among several species o...