+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of electroacupuncture of "Fenglong" (ST 40) on levels of blood lipid and macrophage TNF-alpha and IL-6 in hyperlipidemic rats

, : Effect of electroacupuncture of "Fenglong" (ST 40) on levels of blood lipid and macrophage TNF-alpha and IL-6 in hyperlipidemic rats. Zhen Ci Yan Jiu 38(6): 459-464

To observe the effect of electroacupuncture (EA) stimulation of "Fenglong" (ST 40) on blood lipid contents and inflammatory factor levels in hyperlipemia rats so as to elucidate its mechanism underlying improvement of hyperlipemia. Fifty male SD rats were randomized into 5 groups: normal, model, diet -control, EA intervention (EA), diet-control + EA groups, with 10 rats in each group. Hyperlipemia model was established by feeding the animals with high-fat diet for 30 days. After modeling, rats in the diet-control group were fed with routine fodder. EA was applied to bilateral "Fenglong" (ST 40) for 30 min, once daily for 30 days. Following intraperitoneal injection of 1640 culture fluid, the peritoneal fluid was collected and centrifuged for extracting macrophages. Flow cytometry (FCM) was employed to determine the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) after adding fluoresce-labeled antibodies. The contents of serum TC and LDL-C were remarkably higher and HDL-C level was significantly lower in the model group than in the normal group (P < 0.01). After EA intervention, serum TC and LDL-C showed an apparent decrease (P < 0.01). Compared with the normal group, percentages of CD11 b, TNF-alpha and IL-6 were significantly increased in the model group (P < 0.01), while in comparison with the model group, percentages of CD11 b in both EA and diet-control + EA groups, TNF-alpha and IL-6 percentages of macrophages in the diet-control, EA and diet-control + EA groups were notably decreased (P < 0.05, P < 0.01). The effects of the diet-control + EA group were considerably superior to those of the diet-control group in lowering CD11 b, TNF-alpha and IL-6 percentages (P < 0.05, P < 0.01). No significant differences were found between the diet-control and EA groups in the aforementioned indexes (P > 0.05). CD11 b level indicates changes of macrophage level due to its specific marker character. EA stimulation of "Fenglong" (ST 40) is effective in lowering serum TC, LDL-C, and macrophage TNF-alpha and IL-6 levels in hyperlipemia rats.


PMID: 24579360

Other references

Selby, J.V., 1997: Cost sharing in the emergency department--is it safe? Is it needed?. New England Journal of Medicine 336(24): 1750-1751

Steponkus, P.L.; Wiest, S.C., 1979: Freeze-thaw induced lesions in the plasma membrane. The effect of freezing and free-thaw cycles on isolated plant protoplasts is discussed in relation to volumetric changes which also occur under osmotic stress and which impose the same stresses of contraction and expansion. Osmometric behaviour is...

Mediavilla, S.; Escudero, A., 2003: Leaf life span differs from retention time of biomass and nutrients in the crowns of evergreen species. A long leaf life span has been interpreted as an adaptation to low nutrient availability. It is commonly assumed that a long leaf life span permits a longer utilization of nutrients in the leaf biomass and that this contributes to improving nutrie...

Bizet, V.; Pannecoucke, X.; Renaud, J-Luc.; Cahard, D., 2012: Ruthenium-catalyzed redox isomerization of trifluoromethylated allylic alcohols: mechanistic evidence for an enantiospecific pathway. Transfer news: A synthetic approach to chiral β-CF(3)-substituted saturated carbonyl compounds has been developed in which ruthenium complexes efficiently catalyze the redox isomerization of CF(3)-bearing allylic alcohols by an intramolecular sup...

Shigiya R.; Itoh K.; Suhara K.; Sameshima M.; Suzuki H., 1973: Spectral analysis of surface electro myogram. Electroencephalography & Clinical Neurophysiology 34(7): 799-800

Govorushko S.M., 1984: The transport of rock fragments of block trains by ice. Materialy Glyatsiologicheskikh Issledovaniy, Khronika Obsuzhdeniya 51: 254-255

Warren, L.G.; Manwell, R.D., 1952: The glycolytic rato of malarial blood (Plasmodium relictum). Proceedings of the Society of Protozoologists, 3: 14

Gall, C.; Spuler, A.; Fraunberger, P., 1999: Subarachnoid hemorrhage in a patient with cerebral malaria. The case is reported of a 54-year-old woman who presented with a subarachnoid haemorrhage 5 days after returning to Germany from a trip to Kenya. Blood screening revealed a Plasmodium falciparum parasitaemia of 15%, and parasites were detected in...

Ali Mohammad Malekasgar; Hamid Galledari; Hayat Mombaini, 2007: Microdeletions of 'Y' chromosome in infertile males referred to Mehr infertility center in Rasht city of Iran. Toxicology Letters 172(supp-S)

Parise, C.; Caggiano, V., 2015: Disparities in the risk of the ER/PR/HER2 breast cancer subtypes among Asian Americans in California. Population-based studies of breast cancer often aggregate all Asians into a single category termed Asian/Pacific Islander (API). (1) Describe the demographic and clinicopathologic features of early breast cancer utilizing all eight ER/PR/HER2 subt...