geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe and NADPH


, : Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe and NADPH. Journal of Clinical Biochemistry and Nutrition 49(3): 207-215

In order to clarify the mechanism by polyphenols of protective effects against oxidative damage or by quinolinic acid of its neurotoxic and inflammatory actions, effects of polyphenols or quinolinic acid on the radical formation were examined. The ESR measurements showed that some polyphenols such as caffeic acid, catechol, gallic acid, D-(+)-catechin, L-dopa, chlorogenic acid and L-noradrenaline inhibited the formation of radicals in the reaction mixture of rat liver microsomes with ADP, Fe(3+) and NADPH. The ESR measurements showed that α-picolinic acid, 2,6-pyridinedicarboxylic acid and quinolinic acid (2,3-pyridinedicarboxylic acid) enhanced the formation of radicals in the reaction mixture of rat liver microsomes with Fe(3+) and NADPH. Caffeic acid and α-picolinic acid had no effects on the formation of radicals in the presence of EDTA, suggesting that the chelation of iron ion seems to be related to the inhibitory and enhanced effects. The polyphenols may exert protective effects against oxidative damage of erythrocyte membrane, ethanol-induced fatty livers, cardiovascular diseases, inflammatory and cancer through the mechanism. On the other hand, quinolinic acid may exert its neurotoxic and inflammatory effects because of the enhanced effect on the radical formation.

US$19.90

PMID: 22128221

DOI: 10.3164/jcbn.11-16


Other references

Miyajima, A.; Ito, K.; Asano, T.; Seta, K.; Ueda, A.; Hayakawa, M., 2001: Does cyclooxygenase-2 inhibitor prevent renal tissue damage in unilateral ureteral obstruction?. Purpose: We determined whether the cyclooxygenase-2 inhibitor etodolac affects renal tubular damage and interstitial fibrosis in unilateral ureteral obstruction. Materials and Methods: Etodolac (10 mg./kg.) was administered to rats 1 day before un...

Kim, D.Suk.; Choi, Y.Jin.; Oh, S.Ho.; Lee, M-Geol., 2010: A case of indolent CD56-positive lymphomatoid papulosis. Journal of the American Academy of Dermatology 63(6): E114-E116

Cabrera-Nguyen, E.Peter.; Cavazos-Rehg, P.; Krauss, M.; Bierut, L.J.; Moreno, M.A., 2016: Young Adults' Exposure to Alcohol- and Marijuana-Related Content on Twitter. Twitter is among the most popular social media platforms used by young adults, yet it has been underutilized in substance use research compared with older platforms (e.g., MySpace and Facebook). We took a first step toward studying the association...

Swarup, S.; Saxena, V.K.; Prasad, C.R., 1991: Synthesis and pharmacological screening of some new N-[4-(N,N-disubstituted aminocarbonyl)phenyl]-3,5-dinitrobenzoic acid hydrazides. Ten title compounds were synthesized by the action of N-[4-carboxyphenyl]-3,5-dinitrobenzoic acid hydrazide with thionyl chloride, followed by condensation with different secondary amines. The synthesized compounds were screened for toxicity, gros...

Scott B.A.; Gibson F.B.; Calhoun K.H.; Samuelson T.E., 1991: Management of the ptotic lid after neck dissection. Southern Medical Journal 84(9): 2S65

Sawai, E., 1988: Items to be noted by ward nurses in dealing with terminal care: interview with Ms. Eimi Sawai, a nurse at Toranomon Hospital. Interview by A. Uchinuno. Kangogaku Zasshi 52(11): 1091-1096

Raffoux, C.; Demenais, F.; Dupré, N.; Feingold, N.; Streiff, F., 1983: Exclusion of a tight linkage between familial polyposis coli and HLA. Linkage was investigated between a dominant gene determining familial polyposis coli (FPC) and HLA in a large pedigree. A tight linkage was excluded at a value of the recombination fraction between 0 and 5%. Linkage studies with various markers sh...

Chen J.D.; Kim J.P.; Sarret Y.; Wynn K.C.; Woodley D.T., 1992: Recombinant human epidermal growth factor regf promotes human keratinocyte locomotion. Journal of Investigative Dermatology 98(4): 614

Yamamoto, S.; Imai, R.; Uchiike, T.; Mizuno, R.; Okamoto, Y., 2013: An attempt to classify patients with dementia by detrended fluctuation analysis of electroencephalographic data --a preliminary study. We investigated changes of the scaling exponent alpha estimated by detrended fluctuation analysis (DFA) of electroencephalograms (EEG) in patients with dementia including Alzheimer's disease(AD), and attempted to apply a method of pattern rec...

Foster, Em, 1972: The need for science in food safety. Food technology: 26 (8) 81-82