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Effectiveness of myocardial perfusion scintigraphy to predict coronary anatomy in patients with non-ST elevation acute coronary syndrome

, : Effectiveness of myocardial perfusion scintigraphy to predict coronary anatomy in patients with non-ST elevation acute coronary syndrome. American Journal of Cardiology 104(5): 644-647

The risk stratification of conservatively managed patients presenting with non-ST elevation (NSTE) acute coronary syndromes (ACS) is frequently accomplished by the use of myocardial perfusion scintigraphy (MPS) in clinical practice. However, whether one can predict the extent of coronary artery disease (CAD) on angiography by MPS in this setting is unknown. In this study, the correspondence of findings on MPS to those on coronary angiography was retrospectively analyzed in 55 patients presenting with NSTE ACS. Patients' mean age was 64 years, 55% were men, and 87% had positive troponins. Of these patients, 42% of patients with perfusion defects involving the anterior wall presented with significant extensive CAD on coronary angiography, consisting of left main disease, 3-vessel disease, or 2-vessel disease involving the left anterior descending coronary artery. In patients with perfusion defects limited to 1 territory, 50% also had extensive CAD. A "negative" result on MPS was associated with extensive CAD in 37% of patients and the absence of significant lesions in only 8%. In conclusion, these findings suggest that MPS alone may be of limited clinical utility in distinguishing troponin-positive NSTE ACS patients with extensive CAD from those with more limited disease and should prompt further investigation of the use of MPS for this indication.


PMID: 19699338

DOI: 10.1016/j.amjcard.2009.04.051

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Ramesh, C.; Chellappan, P.; Mahadevan, A., 2001: Comparison of protein profiles and enzymes in non-mycorrhizal and mycorrhizal roots of Pennisetum pedicellatum. Pennisetum pedicellatum plants were inoculated with Glomus mosseae, G. aggregatum and Gigaspora margarita. There were both quantitative and qualitative changes in the protein pattern of inoculated plants. Gi. margarita induced increase in protein...

Thueroff, S.; Chaussy, C., 1997: In situ extracorporeal shock wave lithotripsy with Booster technique in the treatment of ureteral stones. After treatment of more than 3000 kidney and ureteral stones with the Siemens Lithostar Multiline the results of the first 1400 ureteral stone treatments using the "Booster technique" and 3-month follow-up findings are reported. There wa...

Harris, S.; Karlsson Green, K.; Pettersson, L.B., 2014: Predator faunas past and present: quantifying the influence of waterborne cues in divergent ecotypes of the isopod Asellus aquaticus. Waterborne chemical cues are an important source of information for many aquatic organisms, in particular when assessing the current risk of predation. The ability to use chemical cues to detect and respond to potential predators before an actual...

Walsingham, Lord., 1885: Characters of Two New Geuera of Pterophoridae, from Specimens in the British Museum. Entomologist's Monthly Magazine, XXI 175 & 176

Vemulapalli, S.; Chiu, P.J.; Barnett, A., 1984: Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. Platelet-activating factor (PAF) has hypotensive effects similar to those of antihypertensive polar renomedullary lipid (APRL), a potent endogenous hypotensive lipid. In this study the cardiovascular and renal effects of PAF were characterized in...

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Barton, Nick., 2000: Mousterian hearths and shellfish: late Neanderthal activities on Gibraltar. Unknown

Radchenko, M.; Nie, R.; Lu, M., 2016: Disulfide Cross-linking of a Multidrug and Toxic Compound Extrusion Transporter Impacts Multidrug Efflux. Multidrug and toxic compound extrusion (MATE) transporters contribute to multidrug resistance by extruding different drugs across cell membranes. The MATE transporters alternate between their extracellular and intracellular facing conformations to...

Anonymous, 2013: Increased Circulating Lin-/lowCD33+HLA-DR- Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients. Myeloid derived suppressor cells (MDSCs) can be induced or expanded in tumor-bearing mice and cancer patients. The frequency of MDSCs denoted here as Lin-/lowCD33+HLA-DR- was investigated in hepatocellular carcinoma (HCC) patients. The clinical re...

Lin, F.M.; Bell, K.R.; Buford, J.A.; Anderson, M.E., 1998: The control of repetitive bimanual index movements and the influence of external timing signals in Parkinsons diseases. Society for Neuroscience Abstracts 24(1-2): 1664