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Effectiveness of psychotherapeutic, pharmacological, and combined treatments for chronic depression: a systematic review (METACHRON)

, : Effectiveness of psychotherapeutic, pharmacological, and combined treatments for chronic depression: a systematic review (METACHRON). Bmc Psychiatry 10(): 95-95

Chronic depressions represent a substantial part of depressive disorders and are associated with severe consequences. Several studies were performed addressing the effectiveness of psychotherapeutic, pharmacological, and combined treatments for chronic depressions. Yet, a systematic review comparing the effectiveness of multiple treatment options and considering all subtypes of chronic depressions is still missing. Aim of this project is to summarize empirical evidence on efficacy and effectiveness of treatments for chronic depression by means of a systematic review. The primary objectives of the study are to examine, which interventions are effective; to examine, if any differences in effectiveness between active treatment options exist; and to find possible treatment effect modifiers. Psychotherapeutic, pharmacological, and combined treatments will be considered as experimental interventions and no treatment, wait-list, psychological/pharmacological placebo, treatment as usual, and other active treatments will be seen as comparators. The population of patients will include adults with chronic major depression, dysthymia, double depression, or recurrent depression without complete remission between episodes. Outcomes of the analyses are depressive symptoms, associated consequences, adverse events, and study discontinuation. Only randomized controlled trials will be considered. Given the high prevalence and serious consequences of chronic depression and a considerable amount of existing primary studies addressing the effectiveness of different treatments the present systematic review may be of high relevance. Special attention will be given to the use of current methodological standards. Findings are likely to provide crucial information that may help clinicians to choose the appropriate treatment for chronically depressed patients.


PMID: 21092304

DOI: 10.1186/1471-244X-10-95

Other references

Chen Z W.; Agerberth B.; Gell K.; Andersson M.; Mutt V.; Ostenson C G.; Efendic S.; Barros Soderling J.; Persson B.; Jornvall H., 1988: Isolation and characterization of porcine diazepam binding inhibitor a polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release. The polypeptide DBI (diazepam-binding inhibitor) has been purified from the porcine upper intestine, where it is abundant. Porcine mature DBI is composed of 86 amino acid residues and has a blocked N-terminus. The primary structure, the first DBI...

Nabedryk Viala E.; Calvet P., 1975: Effect of oxido reduction on deuterium hydrogen exchange kinetics of cytochrome c. Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences Serie D Sciences Naturelles 280(1): 125-128

Boniatti, Márcio.Manozzo.; Diogo, L.Passamani.; Almeida, C.Lorenzoni.; Cardoso,, 2009: Prevalence and record of alcoholism among emergency department patients. The purpose of this study was to investigate the prevalence of alcoholism among inpatients, to identify social and demographic factors associated with this prevalence and to determine its rate of recognition by the medical team. The study populati...

Silva, C.; Martini, T.; Tavares, G.; Silveira, T.; De-Oliveria, M.-Cristina; Teixeira, H., 2006: Caracterizacao fisico-quimica de nanoemulsoes cationicas como sistemas de liberacao de oligonucleotideos. "Physicochemical Characterization of Cationic Nanoemulsions as Delivery Systems for Oligonucleotides". The present paper reports the influence of increasing amounts of the cationic lipid stearylamine (SA) and the presence of the non-ioni...

Hirano, K.; Yamada, S.; Kimura, R.; Uchida, S.; Hashimoto, H., 2001: Binding characteristics of selective serotonin reuptake inhibitors on brain serotonin transporter after the oral administration. Japanese Journal of Pharmacology 85(Supplement 1): 234P

Weiss P.A., 1971: Within the gates of science and beyond science in its cultural commitments. Within The Gates Of Science And Beyond Science in Its Cultural Commitments 328

Chiu, S.J.; Lokhnygina, Y.; Dubis, A.M.; Dubra, A.; Carroll, J.; Izatt, J.A.; Farsiu, S., 2013: Automatic cone photoreceptor segmentation using graph theory and dynamic programming. Geometrical analysis of the photoreceptor mosaic can reveal subclinical ocular pathologies. In this paper, we describe a fully automatic algorithm to identify and segment photoreceptors in adaptive optics ophthalmoscope images of the photoreceptor...

Van Bijsterveld O.P.; Aalders Deenstra V., 1986: Clinical testing of n acetylaspartylglutamic acid eye drops in subacute and chronic atopic conjunctivitis. Patients with subacute and chronic atopic conjunctivities who were treated for at least one year with topically applied 2% sodium cromoglycate 4 times daily were switched to N.A.A.G.A. 6% eye drops for 2 months. A statistically significant gain in...

Hardy, D.Elmo, 1967: Studies of fruitflies associated with mistletoe in Australia and Pakistan with notes and descriptions on genera related to Perilampsis Bezzi. This paper treats the known species of fruitflies associated with mistletoe (Loranthaceae) in Asia and the Pacific and gives descriptive notes on related African genera. The following are described as new: PARACERATITELLA gen. n., P. eurycephala s...

Wortz, E.C.; Schreck, W.; Robertson, W.; Lamb, G.; Browne, L., 1969: A study of astronauts' extravehicular work capabilities in weightless conditions. NASA CR-1334. Nasa Contractor Report. Nasa Cr. United States. National Aeronautics and Space Administration: 1-233