+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effectiveness of treatment with oral paricalcitol in patients with pre-dialysis chronic kidney disease

, : Effectiveness of treatment with oral paricalcitol in patients with pre-dialysis chronic kidney disease. Nefrologia 31(6): 697-706

Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease. Treatment with paricalcitol, a selective vitamin D receptor (VDR) activator, has shown benefits in these patients by adequately reducing PTH levels with minimal changes in serum calcium and phosphorus. The aim of this study was to assess the effectiveness and safety of paricalcitol in chronic renal disease patients (CKD grades 3 and 4). A study of our experience with paricalcitol was conducted in normal clinical practice in patients over 18 years diagnosed with grade 3 or 4 chronic kidney disease. Patients were periodically evaluated every 3 months. The primary endpoint of effectiveness was to obtain two consecutive decreases of ≥30% in iPTH with respect to baseline values. The secondary endpoints were fulfilment of the objectives in accordance with the Spanish Society of Nephrology (SEN) and Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines, as well as the relationship between the effectiveness of the treatment and different patient variables. Safety was studied by means of hypercalcaemia events. The primary study endpoint was achieved in 54.3% of patients. In addition, another 16.3% of patients had reduced iPTH by more than 30% at the 3rd visit. Therefore, 70.6% of patients reduced their iPTH levels by more than 30% in 6 months. The relationship between treatment success and both glomerular filtration rate and body mass index was significant. There were few adverse events, although hypercalcaemia was found in 5.4% of patients. Treatment with paricalcitol is effective in controlling secondary hyperparathyroidism in non-dialysed patients with a wide safety margin.


PMID: 22130286

DOI: 10.3265/Nefrologia.pre2011.Aug.11030

Other references

Anonymous, 1983: Farm management. 7. Investing capital in horticulutre. Leaflet Great Britain Ministry of Agriculture Fisheries and Food Agricultural Development and Advisory Service: (867)

Smith, S.E.; French, M.M.; Julian, J.; Paria, B.C.; Dey, S.K.; Carson, D.D., 1997: Expression of heparan sulfate proteoglycan (perlecan) in the mouse blastocyst is regulated during normal and delayed implantation. Previous studies have shown that expression of the heparan sulfate proteoglycan, perlecan, on the external trophectodermal cell surfaces of mouse blastocysts increases during acquisition of attachment competence. However, it is not clear if this c...

Redelsteiner, C., 2010: Peter Baskett in daily student life. Resuscitation 81(5): 636-636

Mcmaster M.E.; Munkittrick K.R.; Van Der Kraak G.J., 1992: Protocol for measuring circulating levels of gonadal sex steroids in fish. Alterations in circulating levels of sex steroids have been found in fish captured near bleached kraft pulp mills, and have been associated with a number of other physiological and whole organism responses. The Environmental Effects Monitoring Req...

Weidman, W.H.; DuShane, J.W., 1974: Course of pulmonary hypertension following surgical closure of ventricular septal defect. Advances in Cardiology 11(00): 131-134

Alvarenga H.M.F.; Bonaparte J.F., 1992: A new flightless landbird from the cretaceous of patagonia. Natural History Museum of Los Angeles County Science Series (36): 51-64

Chen, L.; Yi, H.; Zhong, H.; Hu, R.; Yin, J.; Yang, J., 2006: The calcareous nannofossil record and its geological significance in the Jurassic black shales from the Qiangtang Basin, northern Tibetan Plateau. A new record of calcareous nannofossils in Jurassic black shales from the Qiangtang Basin, northern Tibet comprises two series, representing shelf to basin settings. By microscopic observation, the first discovery of the family Watznaueriaceae has...

Broughton, P.M.; Buckley, B.M., 1985: The need for better plasma cholesterol assays. Annals of Clinical Biochemistry 22: 547-549

Bartram E.B., 1972: Mosses of the philippines. Mosses Of The Philippines 437

Nesterov V.A., 1982: Stormy microseisms in Shikotan Island and water pressure fluctuations on the Pacific Ocean floor. Vulkanologiya i Seysmologiya 1982(2): 73-79