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Effects of environmental endocrine disruptors and phytoestrogens on the kisspeptin system

, : Effects of environmental endocrine disruptors and phytoestrogens on the kisspeptin system. Advances in Experimental Medicine and Biology 784: 455-479

Sex steroid hormones, most notably estradiol, play a pivotal role in the sex-specific organization and function of the kisspeptin system. Endocrine--disrupting compounds are anthropogenic or naturally occurring compounds that interact with steroid hormone signaling. Thus, these compounds have the potential to disrupt the sexually dimorphic ontogeny and function of kisspeptin signaling pathways, resulting in adverse effects on neuroendocrine physiology. This chapter reviews the small but growing body of evidence for endocrine disruption of the kisspeptin system by the exogenous estrogenic compounds bisphenol A, polychlorinated biphenyl mixtures, and the phytoestrogen genistein. Disruption is region, sex, and compound specific, and associated with shifts in the timing of pubertal onset, irregular estrous cycles, and altered sociosexual behavior. These effects highlight that disruption of kisspeptin signaling pathways could have wide ranging effects across multiple organ systems, and potentially underlies a suite of adverse human health trends including precocious female puberty, idiopathic infertility, and metabolic syndrome.


PMID: 23550019

DOI: 10.1007/978-1-4614-6199-9_21

Other references

Atala, A., 2000: Tissue engineering of artificial organs. Tissue engineering efforts are currently being undertaken for every type of tissue and organ within the urinary system. Most of the effort expended to engineer genitourinary tissues has occurred within the last decade. Tissue engineering technique...

Gong, J.; Huang, J-zhong.; Xie, M-qiang., 2012: Resection of laryngeal chondroma and functional reconstruction: case report. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 46(10): 868-869

Ku, J.Hyeon.; Cho, J.Yeon.; Cho, S.Yong.; Kim, S.Woong.; Paick, J-Seung., 2010: The one year outcome after KTP laser vaporization of the prostate according to the calculated vaporized volume. The aim of this study was to develop a new simple method for measuring the vaporized volume and to evaluate the outcome of high-power potassium-titanyl-phosphate (KTP) photoselective laser vaporization. A total of 65 patients, with a mean age of 6...

Movshovich, B.L., 1966: The glucidogram in agar gel. Laboratornoe Delo 12: 711-712

Williams, J., 1965: Assassinations. Medico-Legal Journal 33(3): 93-104

Karlin, I.W., 1958: Speech- and language-handicapped children. A.M.A. Journal of Diseases of Children 95(4): 370-376

Wortham, J W.E.; Jr., 1976: Comparative morphology of some plethodontid salamander spermatozoa. Dissertation Abstr lnt, 376: 2716

Achs, M.J.; Garfinkel, D., 1968: Simulation of the detailed regulation of glycolytic oscillation in a heart supernatant preparation. Computers and Biomedical Research, An International Journal 2(1): 92-110

Anonymous, 1985: Collaborative research on groundnut rosette virus. The opening address, which includes the objectives of the meeting, summaries of the 8 papers given on various aspects of the virus, recommendations and a list of participants are included in these proceedings of the Consultative Group meeting to d...

Croft, DB., 1977: The effect of photoperiod length on the diurnal activity of canaries. The effect of photoperiod length on the diurnal activity of canaries. Doctoral Dissertation, University of Cambridge, 1975 i-v,1-265