+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: a prospective randomized double-blind placebo-controlled study

, : Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: a prospective randomized double-blind placebo-controlled study. Medical Principles and Practice 19(1): 57-60

To evaluate the effect of gabapentin on the incidence and severity of postoperative nausea and vomiting (PONV) after open cholecystectomy. A total of 90 patients scheduled for elective open cholecystectomy were randomly assigned to either a gabapentin group (600 mg, 2 h before surgery) or a placebo group. For the analysis, 1 patient was excluded from the gabapentin group and 2 patients from the placebo group. A standard technique was used for anesthesia. Pethidine and metoclopramide were used for postoperative management of pain and nausea/vomiting, respectively. The prevalence of PONV, its severity (measured on visual analogue scale, VAS), and total pethidine and metoclopramide use in the first 24 h after the operation were recorded. There were no demographic differences between the two groups. Of the 44 patients given gabapentin, 16 (36.6%) and 28 of 43 (65.2%) placebo patients developed PONV; the difference was statistically significant (p = 0.02). However, there was no difference in the severity of PONV between the gabapentin and placebo groups (p = 0.12). Gabapentin patients used less pethidine (28.33 +/- 129 mg) and metoclopramide (6.0 +/-6.3 mg) than the placebo group (35.1 +/- 15.1 and 9.33 +/- 7.1 mg, respectively). The differences were statistically significant (pethidine: p = 0.002, metoclopramide: p = 0.033). However, gabapentin did not reduce postoperative pain significantly (p = 0.096). Our data show that gabapentin not only reduced PONV after open cholecystectomy, but also reduced the need for additional postoperative analgesics.


PMID: 19996621

DOI: 10.1159/000252836

Other references

Brown, T.D.J.; Raalte, J.L. van; Brewer, B.W.; Winter, C.R.; Cornelius, A.E.; Andersen, M.B., 2002: World Cup Soccer home advantage. A number of situational factors (e.g., familiarity with playing facilities, distance travelled to a game, game importance) have been hypothesized to contribute to the home advantage (HA) effect. To assess the relationship between these factors and...

Leihner, D.E.; Ruppenthal, M.; Hilger, T.H.; Castillo, J.A., 1996: Soil conservation effectiveness and crop productivity of forage legume intercropping, contour grass barriers and contour ridging in cassava on Andean hillsides. Soil erosion and the productivity of cassava (Manihot esculenta Crantz) cropping systems, including forage legume intercropping, were monitored under natural rainfall conditions on Inceptisols in southwest Colombia. Trials were conducted over two...

Hahn, W.A., 1982: Involuntary commitment and the right to refuse treatment with anti-psychotic drugs. Creighton Law Review 16(3): 719-742

O'Dowd, A., 2002: Psychiatric nursing. The way you look freaks me out. Nursing Times 96(27): 12-13

Guerin C.; Heritier P.; Sabatier J.C.; Berthoux F., 1988: Renal failure and marked genital prolapse two cases. Journal de Gynecologie Obstetrique et biologie de la Reproduction 17(4): 507-510

Goraya, J.S.; Singh, G.; Singh, S.; Gill, S.S.; Goyal, A.; Mitra, S.K.; Kumar, L., 1998: Arteriovenous malformation of knee masquerading as juvenile arthritis. This is a rare case of involvement of knee joint by an arteriovenous malformation. A nine year old girl had recurrent monoarticular pain and swelling of long duration and had been treated as juvenile rheumatoid arthritis. Angiographic and histolog...

Piano C.; Carulli Giovanni Battista, 2002: Jurassic sedimentation and tectonics of the Mount Verzegnis area (northeastern Carnian Prealps). The Mt. Verzegnis (Carnian Prealps) is part of the eastern Southern Alps. On the basis of detailed field mapping and microfacies and palynofacies analysis, it has been possible to understand and reconstruct the overall depositional geometries and...

Tokunaga, Yukihiko; Hosogi, Hisahiro; Hoppou, Toshitaka; Nakagami, Mikio; Tokuka, Atsuo; Ohsumi, Kiyoshi, 2002: Prognostic value of thymidine phosphorylase/platelet-derived endothelial cell growth factor in advanced colorectal cancer after surgery: Evaluation with a new monoclonal antibody. Background: Thymidine phosphorylase (TP) is an essential enzyme for activation of 5-fluorouracil and its derivatives and identical to platelet-derived endothelial cell growth factor. In colorectal cancer (CRC), previous studies evaluating the rela...

Hawley, G., J.; Schaberg, P., G.; Eagar, C.; Borer, C., H., 2000: Calcium addition at the Hubbard Brook Experimental Forest reduced winter injury to red spruce in a high-injury year. Laboratory experiments have verified that acid-deposition-induced calcium (Ca) leaching reduces the foliar cold tolerance of red spruce (Picea rubens Sarg.) current-year foliage, increasing the risk of winter injury and crown deterioration. Howev...

Bernardi, G.C., 1968: The urinary chorionic gonadotropin level in various stages of normal pregnancy. Archivio di Ostetricia E Ginecologia 73(3): 397-412