geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of the levonorgestrel-releasing intrauterine system on cardiovascular risk markers in patients with endometriosis: a comparative study with the GnRH analogue


, : Effects of the levonorgestrel-releasing intrauterine system on cardiovascular risk markers in patients with endometriosis: a comparative study with the GnRH analogue. Contraception 81(2): 117-122

The study was conducted to evaluate the cardiovascular risk markers associated with endometriosis and the influence of the levonorgestrel intrauterine system (LNG-IUS) compared with the GnRH analogue (GnRHa) leuprolide acetate on these risk markers after 6 months of treatment. This was a randomized, prospective, open clinical study, with 44 patients with laparoscopically and histologically confirmed endometriosis. Patients were randomized into two groups: the LNG-IUS group, composed of 22 patients who underwent LNG-IUS insertion, and the GnRHa group, composed of 22 patients who received a monthly GnRHa injection for 6 months. Body mass index; systolic and diastolic arterial blood pressure; heart rate; and laboratory cardiovascular risk markers such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), homocysteine (HMC), lipid profile, total leukocytes and vascular cell adhesion molecule (VCAM) were measured before and 6 months after treatment. After 6 months of treatment, a significant reduction in pain score occurred in both groups with no significant difference in improvement between the two medications evaluated. In the LNG-IUS group, from pretreatment to posttreatment period, there was a significant reduction in the levels (mean+/-SD) of VCAM (92.8+/-4.2 to 91.2+/-2.7 ng/mL, p=.04), CRP (0.38+/-0.30 to 0.28+/-0.21 mg/dL, p=.03), total cholesterol (247.0+/-85.0 to 180.0+/-31.0 mg/dL, p=.0002), triglycerides (118.0+/- 76.0 to 86.5+/-41.5 mg/dL, p=.003), low-density lipoprotein cholesterol (160.5+/-66.0 to 114.5+/-25.5 mg/dL, p=.0005) and high-density lipoprotein cholesterol (63.0+/-20.5 to 48.5+/-10.5 mg/dL, p=.002). The GnRHa group showed an increase in HMC levels (11.5+/-2.9 to 13.0+/-2.7 mumol/L, p=.04) and a reduction in IL-6 levels (4.3+/-3.9 to 2.3+/-0.8 pg/mL, p=.005), VCAM (94.0+/-3.8 to 92.0+/-1.6 ng/mL, p=.03) and total leukocytes (7330+/-2554 to 6350+/-1778, p=.01). In the GnRH group, the remaining variables, including lipid profile, did not show any statistical difference. This study shows that some cardiovascular risk markers are influenced by both GnRHa and the LNG-IUS, but the latter had a greater positive impact on the lipid profile, which could lead to a favorable effect during long-term treatment.

US$19.90

PMID: 20103448

DOI: 10.1016/j.contraception.2009.08.003


Other references

Escudero, M., 2002: Spains fish market a catch for U.S. exporters. AgExporter 14(11): 15-16

Shekleton, M.E., 1987: Nursing diagnosis: where we've been and where we're going. Chart 84(4): 2, 6-2, 6

Oliviero, C.; Heinonen, M.; Valros, A.; Peltoniemi, O., 2010: Environmental and sow-related factors affecting the duration of farrowing. A short duration of farrowing is important for piglet survival as a delay can increase the number of stillborn. Many factors may affect the duration of farrowing, including breed, age of the sow, length of gestation, number of piglets born, housin...

Flanders, S.E.; Badgley, M.E., 1960: A host-parasite interaction conditioned by predation. Ecology, 41: 363-365

Chaudry M.A.; Hussain B.; Khan I Aman; Ahmad M., 1989: Effect of peeling methods on the nutritional and organoleptic characteristics of dehydrated potatoes. The effect of hand and abrasive Peeling and storage period was investigated on the dehydrated Cardinal and Patrones cultivars of potatoes stored at room temperature (10.5-30.degree.C) for 3 months. Hand peeling resulted in more peeling loss than a...

Aziz, K.E.; Mccluskey, P.J.; Wakefield, D., 1994: Adhesion molecule expression in minor salivary glands from patients with primary Sjogrens syndrome. Nussenblatt, R B , Whitcup, S M , Caspi, R R , Gery, I International Congress Series; Advances in ocular immunology 307-310

Saban, R.; Wershil, B.; Haak Frendscho, M.; Deboer, D.; Zine, M.; Bjorling, D.E., 1996: Differential responses of tracheal and bladder segments isolated from control and mast cell-deficient mice to antigen challenge following actively and passively sensitization. FASEB Journal 10(6): A1365

King, N.D.; O'brian, M.R., 1997: Identification of the lrp gene in Bradyrhizobium japonicum and its role in regulation of d-aminolevulinic acid uptake. The lrp (leucine-responsive regulatory) gene of Bradyrhizobium japonicum was found to play a role in d-aminolevulinic acid (ALA) uptake. The heme precursor ALA is taken up by the dipeptide permease (Dpp) system in Escherichia coli. Overexpression...

Kesler, C.J., 2009: How do euphorbia plants cause contact dermatitis?. Nursing 39(6): 13-13

Denekamp J.; Hobson B., 1982: Endothelial proliferation in tumors and normal tissues potential clinical applications. British Journal of Radiology 55(657): 704