geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Efficacy and risks of topical 5-fluorouracil in Darier's disease


, : Efficacy and risks of topical 5-fluorouracil in Darier's disease. Annales de Dermatologie et de Venereologie 137(6-7): 455-459

Darier's disease, an autosomal dominant disorder, is often resistant to therapy. There have been few encouraging reports in recent years of treatment using topical 5-fluorouracil (5FU) in this indication. We describe three cases of Darier's disease treated with Efudix: though it initially proved very effective, after several months this treatment became inefficacious. Case 1: a 16-year-old girl with Darier's disease refractory to conventional treatments. Treatment with topical 5FU was initiated. After 3 weeks, her cutaneous lesions had practically disappeared, leaving only pigmented scars. At 6 months, worsening of the disease was controlled by increasing 5FU. At 11 months, the disease worsened and 5FU, which proved inefficient, was stopped. Case 2: a 59-year-old woman presenting treatment-resistant Darier's disease was given 5FU. After 1 week, improvement began and was evident at 4 months. However, after 13 months of treatment, the disease progressed, and increased 5FU proved completely ineffective. Case 3: a 29-year-old woman was hospitalized for inflammatory Darier's disease. Topical 5FU was applied to the left half of the body and a short course of oral corticosteroids was prescribed. After 10 days of treatment, there was a clear improvement. After 6 weeks, the patient showed episodes of healthy skin. However after 3 months, the patient stopped taking her treatment due to inefficacy. While topical 5FU seems to be effective initially in treating Darier's disease, this efficacy subsides over time. Although no adverse effects were noted in our patients, use of 5FU can result in serious adverse reactions. Because of the loss of efficacy of this treatment following initial success, coupled with its poorly evaluated safety, caution must be exercised when prescribing it, particularly in patients with dihydropyriminidine dehydrogenase (DPD) deficiency or for use on damaged skin.

US$19.90

PMID: 20620575

DOI: 10.1016/j.annder.2010.04.002


Other references

Anonymous, 1958: Artificial blood-vessels. Recently, synthetic material has been successfully used in the USSR for preparing artificial blood vessels. Polyvinyl sponges proved to be very suitable for this purpose. The plastic material prepared from these sponges is wrapped around smooth me...

Cload S.T.; Schepartz A., 1991: Recognition of leptomonas collosoma sl rna using tethered oligonucleotide probes. Journal of Biomolecular Structure & Dynamics 8(6): A31

Carvalho, M.A.; Carneiro, R.D.; Pará, J.F.; Cabral F.H.; e Silva, R.C.; Lohmann, J.C., 1976: Sodium nitroprusside in the treatment of heart failure. Arquivos Brasileiros de Cardiologia 29(5): 391-395

Kim, Y.; Hilderbrand, S.A.; Weissleder, R.; Tung, C-Hsuan., 2007: Sugar sensing based on induced pH changes. A sensory assembly consisting of a pH sensitive NIR dye and an arylboronic acid shows ratiometric absorption changes with increased fluorescence intensity upon addition of sugar in aqueous media; this demonstrates a new signal transduction mechani...

Pertama, S., 1983: The under-utilized species in Sabah. A paper presented at a conference held in Kuala Lumpur in 1983 (Bengkel Nasional Mengenai Penggunaan Kayu Kurang Terkenal, Kuala Lumpur, 15 hb-16 hb Ogos. 1983). The text of the paper (10 pp.) gives an account of the forest resource base of Sabah,...

Kozhimannil, K.Backes.; Trinacty, C.Mah.; Busch, A.B.; Huskamp, H.A.; Adams, A.S., 2011: Racial and ethnic disparities in postpartum depression care among low-income women. The goal of this study was to characterize racial-ethnic differences in mental health care utilization associated with postpartum depression in a multiethnic cohort of Medicaid recipients. In a retrospective cohort study, administrative claims dat...

Mann U., 1990: Sedimentological and petrophysical aspects of primary petroleum migration pathways. Pages 152-178 1990

Tian, W.; Zhao, D-Hui., 2009: Leading role of molecular orthopedics in the development of orthopedics. Zhonghua Yi Xue Za Zhi 88(37): 2593-2596

Walsh, K.M.; de Smith, A.J.; Chokkalingam, A.P.; Metayer, C.; Roberts, W.; Barcellos, L.F.; Wiemels, J.L.; Buffler, P.A., 2014: GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL. Blood 122(19): 3385-3387

Gavazzi, M.; Seiler, J.; Aust, W.; Zedaker, S., 2000: The influence of elevated carbon dioxide and water availability on herbaceous weed development and growth of transplanted loblolly pine (Pinus taeda). Loblolly pine (Pinus taeda L.) seedlings were grown in competition with native weeds using soil and seed bank collected from recently chopped and burned areas near Appomattox, Virginia. One-year-old seedlings were planted and weeds allowed to germ...