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Efficacy and tolerability of choline alphoscerate (cereton) in patients with Parkinson's disease with cognitive disorders


, : Efficacy and tolerability of choline alphoscerate (cereton) in patients with Parkinson's disease with cognitive disorders. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 109(11): 42-46

An open 10-day study of treatment effect of cereton in comparison to piracetam has been conducted. Cereton was used in 40 patients (main group) in dosage 1000 mg, piracetam - in 20 patients (control group) in dosage 2000 mg. Both drugs were used intravenous in drops in 200 ml of physiologic saline along with antiparkinsonian medications. Patient's state was assessed with a battery of psychometric scales and neuropsychological tests as well as with instruments for measuring intensity of parkinsonian symptoms, side-effects and quality of life. Marked and moderate improvement of cognitive functions was found in patients of the main group compared to the control one (40% and 25%, respectively, p<0,05). Deterioration of cognitive functions was seen less often in the main group than in the control group (5% and 15%, respectively, p<0,05). Cereton was well-tolerated by patients. Side effects (brief and short-term) were found only in 6 (15%) patients.

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PMID: 20032953


Other references

Wallace, R.H., 1937: Methods Of Sampling Visible Radiation. A comprehensive series of experiments was run on the more significant physical arrangements of the sensitive surfaces of photocells to determine what combinations give the most perfect sampling of light. All tests were run on a duplex recorder des...

Udwadia, F.E.; Datey, K.K.; Ramamoorthy, K.; Sheth, U.K., 1957: Water and electrolyte disturbances in congestive cardiac failure. An attempt to measure the intra- and extracellular alterations in water and electrolyte composition during the development of cardiac failure would seem the most logical method to evaluate its pathogenesis. Since this is not possible, it is assume...

Lecointre, C.; Aupois, R., 1977: Diabetes and buccodental interventions. Cahiers D'odonto-Stomatologie 9(4): 145-150

Hendrix S.D., 1989: Floral herbivory and the apiaceae antagonistic or mutualistic interactions. Bock, J H And Y B Linhart (Ed ) The Evolutionary Ecology Of Plants; Symposium in Honor Of Herbert G Baker, Columbus, Ohio, Usa, August 1987 Xiii+600p Westview Press: Boulder, Colorado, Usa; London, England, Uk Illus Maps Paper 305-322

Buddai, S.K.; Toulokhonova, L.; Bergum, P.W.; Vlasuk, G.P.; Krishnaswamy, S., 2002: Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase. The binding of recombinant nematode anticoagulant protein c2 (NAPc2, an 85-residue polypeptide originally isolated from Ancylostoma caninum) to either factor X or Xa is a requisite step in the pathway for the potent inhibition of VIIa tissue facto...

Garchon, Henri Jean, 1992: Non-MHC-linked genes in autoimmune diseases. The gene responsible for the lpr mutation in MRL mice that are prone to systemic lupus erythematosus has been shown to encode the apoptosis-inducing Fas antigen, thus pointing to control of apoptosis as a major regulatory mechanism in autoimmunity...

Cran, J.W.; Krafft, M.E., 2012: Regioselective cyclizations utilizing a gold-catalyzed [3,3] propargyl ester rearrangement. Angewandte Chemie 51(37): 9398-9402

Hatzfeld, C.; Zeller, N.; Brille, D., 1971: Efficiency of muscle work in chronic lung disease. Scandinavian Journal of Respiratory Diseases. Supplementum 77: 117-117

Gingery, A.; Bradley, E.; Shaw, A.; Oursler, M.Jo., 2003: Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival. We have examined highly purified osteoclasts that were generated in vitro from murine co-culture of marrow precursors with stromal support cells and have found evidence of activation of the MEK/ERK and AKT/NFkappaB survival pathways. Many mature m...

Saksena, S., 1997: Regulatory evolution in device follow-up: are there any simple answers?. Pacing and Clinical Electrophysiology 20(2 Pt 1): 354-355