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Efficacy and tolerability of choline alphoscerate (cereton) in patients with Parkinson's disease with cognitive disorders

, : Efficacy and tolerability of choline alphoscerate (cereton) in patients with Parkinson's disease with cognitive disorders. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 109(11): 42-46

An open 10-day study of treatment effect of cereton in comparison to piracetam has been conducted. Cereton was used in 40 patients (main group) in dosage 1000 mg, piracetam - in 20 patients (control group) in dosage 2000 mg. Both drugs were used intravenous in drops in 200 ml of physiologic saline along with antiparkinsonian medications. Patient's state was assessed with a battery of psychometric scales and neuropsychological tests as well as with instruments for measuring intensity of parkinsonian symptoms, side-effects and quality of life. Marked and moderate improvement of cognitive functions was found in patients of the main group compared to the control one (40% and 25%, respectively, p<0,05). Deterioration of cognitive functions was seen less often in the main group than in the control group (5% and 15%, respectively, p<0,05). Cereton was well-tolerated by patients. Side effects (brief and short-term) were found only in 6 (15%) patients.


PMID: 20032953

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