geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Efficacy of an echo contrast agent, SH/TA-508, in color doppler sonography of mass lesions in urology


, : Efficacy of an echo contrast agent, SH/TA-508, in color doppler sonography of mass lesions in urology. Urologic Oncology 1(5): 215-222

We performed a clinical phase III study with a galactosebased ecoo contrast agent, SH/TA-508, to evaluate its efficacy, safety, and usefulness for mass lesions in urology. SH/TA-508 was prepared as a suspension containing stabilized micro-air bubbles by adding water for injection just before use. SH/TA-508 was administered into the antecubital vein at an initial dose of 300 mg/ml × 5 ml followed by higher doses of 400 mg/ml × 4 ml, 300 mg/ ml × 10 ml or 400 mg/ml × 8 ml when a sufficient effect was not obtained. Efficacy was evaluated by color Doppler signal enhancement, the duration of blood flow signal enhancement, and improvement of diagnostic capacity. Fifty-nine patients with mass lesions in the kidney, prostate, testis, adrenal gland, and bladder were enrolled in the study. Up to the third dose the cumulative efficacy rates (≥2+) of color Doppler signal enhancement and duration of blood flow signal enhancement were 92% and 87%, respectively. Consequently, diagnostic capacity in 76% of the patients was remarkably improved. A light transient angialgia occurred in one patient but no other clinically significant changes were observed. It was confirmed that SH/TA-508 is a safe echo contrast agent that offers satisfactory color Doppler signal enhancement in the urologic organs mentioned above.

US$29.90

PMID: 21224121


Other references

Masuda, T.; Yaginuma, H.; Sakuma, C.; Ono, K., 2009: Netrin-1 signaling for sensory axons: Involvement in sensory axonal development and regeneration. During development, dorsal root ganglion (DRG) neurons extend their axons toward the dorsolateral part of the spinal cord and enter the spinal cord through the dorsal root entry zone (DREZ). After entering the spinal cord, these axons project into...

Tulaphitak, T.; Pairintra, C.; Kyuma, K., 1985: Changes in soil fertility and tilth under shifting cultivation. II. Changes in soil nutrient status. Soil nutrient dynamics during the cropping phase of shifting cultivation in northeast Thailand was studied. Following the initial enrichment of soil with major nutrients by slash and burn, losses occurred due to erosion, leaching and crop uptake....

Schnaper, N., 1977: "Down the tube"? No "rescue" -- the language of oncology. New England Journal of Medicine 296(15): 883-883

Pruett, T.L.; Simmons, R.L., 1988: Status of percutaneous catheter drainage of abscesses. The definitive role of catheter drainage in the therapy of abscesses has not yet been totally elucidated. The resolution rate of intra-abdominal infection with catheter drainage is highly variable, depending on the inclusion criteria employed. Cer...

Focke, R.; Franzke, W., 1962: Some differences caused by the alleles su and Su in Z. mays L. Sweet corn varieties were crossed with flint and dent varieties and the grain of the selfed F1 progenies was investigated. The weight of grains with the genotype su/su was 66-84% of that of Su/. grains. It is suggested that the difference in weigh...

Martini, J.; Coraboexuf, xC., 1968: Etude comparative de la densite capillaire coronaire et de la structure myocardique du rat et du cobaye. Journal de Physiologie Paris, 60: 115-126

Sakai J., 1981: Late pleistocene climatic changes in central japan. Journal of the Faculty of Science Shinshu University 16(1): 1-64

Collins, W.B.; Everett, C.F., 1955: Summary report of the 1955 weed control investigations at the Experiment Farm, Fredericton, N.B. CMU at 0.25-3 lb/ac, PDU at 1.5 and 3 lb/ac and 3, 4-DDU at 1 and 1.5 lb/ac were tested pre-em. for their effect on weeds and crop in potatoes, oats, wheat, barley, field peas, fodder corn, turnips and beans. PDU at 1 lb/ac was the most promising,...

Xiao Kai; G.J.nTao; Zhang RongXian; Fang Min, 1997: The preliminary study on the leaf photosynthetic characteristics of hybrid wheat. The differences in photosynthetic characteristics between wheat hybrids and cultivars was compared. The results showed that the third leaf from top and the flag leaf of hybrids had higher values for chlorophyll, photosynthesis, ribulose 1,5-bispho...

Semla, T.P.; Cohen, D.; Freels, S.; Paveza, G.J.; Ashford, J.W.; Gorelick, P.; Luchins, D.; Eisdorfer, C., 1995: Psychotropic drug use in relation to psychiatric symptoms in community-living persons with Alzheimer's disease. We attempted to determine the relationship between psychiatric symptoms and psychotropic drug use in persons with Alzheimer's disease based on a multicenter patient registry of 671 community-living persons diagnosed with the disease by publis...