+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Efficacy of collagenase in patients who did and did not have previous hand surgery for Dupuytren's contracture

, : Efficacy of collagenase in patients who did and did not have previous hand surgery for Dupuytren's contracture. Journal of Plastic Surgery and Hand Surgery 46(3-4): 177-183

Collagenase Clostridium histolyticum (CCH) is a non-surgical, efficacious therapy for Dupuytren's contracture (DC). This study evaluated the efficacy and safety of CCH in patients with previous DC surgery. Data from 12 CCH clinical trials were pooled. At screening, patients provided details about the type/date of previous DC surgery. Reviewers coded descriptions to the Operated Hand, finger, and joint. Of 1082 patients, 422 (39%) had previous DC surgery. For these patients with previous surgery, the CCH treatment was coded on the Operated (n = 206) or Non-operated Hand (n = 196). End-points included changes in fixed-flexion contracture (FFC) and range of motion (ROM). Adverse events (AEs) were monitored. After treatment with CCH, FFC at metacarpophalangeal joints was reduced by 75% in previously Operated Hands and by 80% for Non-operated Hands (p = 0.6). Improvements in ROM were 32° and 32°, respectively (p = 0.9). For proximal inter-phalangeal joints, the reductions in FFC for the Operated and Non-operated Hands were 52% and 50%, respectively (p = 0.6); improvements in ROM were 24° and 26°, respectively (p = 0.3). Some AE rates were significantly higher in the Operated vs Non-operated Hand groups, but were not clinically relevant. There were no between-group significant differences in AE duration (p > 0.08). Previous surgery for DC does not affect efficacy or safety of CCH, suggesting CCH is an option in patients with recurring DC. Some AE rates were significantly higher, but not clinically relevant.


PMID: 22670890

DOI: 10.3109/2000656X.2012.683795

Other references

Fullerton, D.S.; Smets, E.;, G.; Mrus, J.M., 2011: Pharmacoeconomics of darunavir. Darunavir boosted with ritonavir (DRV/r) in combination with other antiretrovirals (ARVs) was initially approved in 2006 for the treatment of HIV infection in ARV treatment-experienced adults and has subsequently been approved for use in treatment...

Jugnia, L., B.; Sime-Ngando, T.; Devaux, J., 2007: Relationship between bacterial and primary production in a newly filled reservoir: temporal variability over 2 consecutive years. Seasonal and spatial variations in bacterial abundance, biomass and production in a recently flooded reservoir were followed for 2 consecutive years, in conjunction with phytoplankton biomass (chlorophyll a) and activity (primary production). Bet...

Abboud, P.A.; Ancheta, R.; McKibben, M.; Jacobs, B.R., 2006: Impact of workflow-integrated corollary orders on aminoglycoside monitoring in children. Computerized provider order entry (CPOE) and clinical decision support improve medication prescribing safety in adults. However, effective therapy for children requires dosing based on circulating medication levels. We examined the introduction of...

Bard, L.A., 1964: Transient Myopia Associated With Promethazine (Phenegan) Therapy: Report Of A Case. American Journal of Ophthalmology 58: 682-686

Musiał, W.J.; Pitschner, H.F.; Neuzner, J., 1993: Transvenous ablation of recurrent ventricular tachycardia in arrhythmogenic right ventricular dysplasia. Catheter ablation was used to cure refractory ventricular tachycardias (VT) in a 20-years old lady with arrhythmogenic right ventricular dysplasia. Antiarrhythmic drugs (procainamide, amiodarone, gilurytmal, flecainide and beta-blockers) used in m...

Nyland T.G., 1982: Ultrasonic diagnosis of canine liver disease. Veterinary Radiology 23(3): 82

Kurosawa, K., 2001: Anophthalmia-limb anomalies. Ryoikibetsu Shokogun Shirizu: 202-203

Murakami, M.; Shimonishi, Y.; Hobo, S.; Niwa, H.; Ito, H., 2015: First isolation of Actinobacillus genomospecies 2 in Japan. We describe here the first isolation of Actinobacillus genomospecies 2 in Japan. The isolate was found in a septicemic foal and characterized by phenotypic and genetic analyses, with the latter consisting of 16S rDNA nucleotide sequence analysis p...

Kunc, F., 1971: Decomposition of coumarin in soil. Manometric measurements of O2 consumption, Chromatographie analysis of metabolites, UV spectroscopy and a simultaneous adaption technique showed that coumarin is decomposed in the soil via alpha -coumaric acid and at least two other aromatic compo...

Mann, F.C., 1958: Hodgepodge for gastroenterologists. American Journal of Digestive Diseases 3(9): 643-658