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Efficacy trials of biomedical strategies to prevent HIV infection

, : Efficacy trials of biomedical strategies to prevent HIV infection. Current Opinion in HIV and Aids 3(4): 504-508

The aim of this article is to outline key challenges facing the conduct of efficacy trials for biomedical strategies to prevent HIV infection. The past 2-3 years have seen tumultuous development in this field. There have been disappointing findings in efficacy trials of vaginal microbicides, vaccines, the diaphragm and suppressive therapy for herpes, but a major breakthrough with the evidence that male circumcision prevents acquisition of infection. Meanwhile, clarity has started to emerge on a number of issues regarding trial conduct, including provision of standard of care, involvement of communities, and preparation for implementing effective interventions. HIV prevention practice must continue to rely on condom promotion and other established strategies while biomedical approaches continue to be assessed and their implementation strategies evolve.


PMID: 19373012

DOI: 10.1097/COH.0b013e32830413dc

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Tribble, C.; Merrill, W.H., 2016: In Your Own Words: Toward a More Perfect Union of Patient Care and Education. Communication with patients and their families is a challenge for busy trainees. It is essential, however, that these trainees learn effective communication skills to create rapport with their patients, to add to their own satisfaction in caring f...

Holloway, E.L.; Polumbo, R.A.; Harrison, D.C., 1975: Acute circulatory effects of dopamine in patients with pulmonary hypertension. Twenty-one patients, 11 with normal pulomonary artery pressures and 10 with pulmonary hypertension, had haemodynamic measurements performed before and during dopamine infusion while undergoing cardiac catheterization, in order to evaluate the circ...

Chiu, H.S.; Kim, S.J.; Rim, H.J., 1982: Electron-microscopic studies on the effect of praziquantel on Paragonimus westermani. Three months after inoculation with P. westermani metacercariae, dogs were treated with praziquantel in 3 doses of 25 or 50 mg/kg/day for 3 days. At autopsy no living worms were found in cysts in the lungs but the cysts were filled with necrotic m...

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Loth, S.R.; Henneberg, M., 1996: Mandibular ramus flexure: a new morphologic indicator of sexual dimorphism in the human skeleton. In the skeleton, male and female characteristics lie along a continuum of morphologic configurations and metric values. Size alone is not the best indicator of sex. In contrast, morphologic differences that arise from genetically sex-linked growth...

Bogolepov V.G.; Davidenko I.V., 1975: Transmagmatic solutions and ground water as factors in regional metamorphism and metasomatism. Transactions (Doklady) of the US

Egyud, J., 1977: Decomposition of animal waste by protease of bacterial origin. Husipar 26 (2) 76-80

Li, X.; Atkins, M.S., 2004: Early childhood computer experience and cognitive and motor development. Objectives. To explore the association between early computer experience (both accessibility and frequency of use) and cognitive and psychomotor development among young children. Methods. The participants were 122 preschool children enrolled in a...

Gregory K.J., 1983: Postscript for palaeohydrology. Pages 479-480 1983