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Electrophysiological correlates of amnestic mild cognitive impairment in a simon task


, : Electrophysiological correlates of amnestic mild cognitive impairment in a simon task. Plos One 8(12): E81506-E81506

Amnestic mild cognitive impairment (aMCI) represents a prodromal stage of Alzheimer`s disease (AD), especially when additional cognitive domains are affected (Petersen et al., 2009). Thus, single-domain amnestic MCI (sdaMCI) and multiple-domain-amnestic MCI (mdaMCI) biomarkers are important for enabling early interventions to help slow down progression of the disease. Recording event-related potentials (ERPs) is a non-invasive and inexpensive measure of brain activity associated with cognitive processes, and it is of interest from a clinical point of view. The ERP technique may also be useful for obtaining early sdaMCI and mdaMCI biomarkers because ERPs are sensitive to impairment in processes that are not manifested at behavioral or clinical levels. In the present study, EEG activity was recorded in 25 healthy participants and 30 amnestic MCI patients (17 sdaMCI and 13 mdaMCI) while they performed a Simon task. The ERPs associated with visuospatial (N2 posterior-contralateral - N2pc -) and motor (lateralized readiness potential - LRP -) processes were examined. The N2pc amplitude was smaller in participants with mdaMCI than in healthy participants, which indicated a decline in the correlates of allocation of attentional resources to the target stimulus. In addition, N2pc amplitude proved to be a moderately good biomarker of mdaMCI subtype (0.77 sensitivity, 0.76 specificity). However, the LRP amplitude was smaller in the two MCI groups (sdaMCI and mdaMCI) than in healthy participants, revealing a reduction in the motor resources available to execute the response in sdaMCI and mdaMCI patients. Furthermore, the LRP amplitude proved to be a valid biomarker (0.80 sensitivity, 0.92 specificity) of both amnestic MCI subtypes.

US$19.90

PMID: 24339941

DOI: 10.1371/journal.pone.0081506


Other references

Hustvedt, G.C.ews, P., 2005: The ultraviolet protection factor of naturally-pigmented cotton. The sun-blocking properties of a textile are enhanced when a dye, pigment, delustrant, or ultraviolet absorber finish is present that absorbs ultraviolet radiation and blocks its transmission through a fabric to the skin. For this reason, dyed fab...

Bernardczykowa, A.; Szczypiński, J., 1967: Treatment of epithelial neoplasms of the conjunctiva. Polish Medical Journal 6(3): 709-717

Overstreet, J.W.; Cooper, G.W., 1978: Sperm transport in the reproductive tract of the female rabbit: 1. The rapid transit phase of transport. Rabbit spermatozoa were recovered from the upper ampulla and the fimbrial and ovarian surfaces of all females examined at 1 min post coitum. As many as 1000 spermatozoa could be recovered, on occasion, from the upper ampulla, fimbria and ovary of...

Luja, V.H.; Ramirez-Bautista, A.; Sanvicente, M., 2005: Crotalus simus tzabcan (neotropical rattlesnake). Diet. Herpetological Review 36(2): 192-193

Schafer, Penny, 2001: Costs, benefits and the metrics of risks. Neurotoxicology (Little Rock) 22(1): 132, February

Barton, K.; Rafinski, J., 2006: Co-occurrence of agile frog (Rana dalmatina Fitz. in Bonaparte) with common frog (Rana temporaria L.) in breeding sites in southern Poland. A location (area 10 km2) of the agile frog (Rana dalmatina Fitz. in Bonaparte) in a southwest part of the Sandomierz Valley (southern Poland), was surveyed during 4 breeding seasons (1999-2002). Eighteen breeding sites of brown frogs were inspecte...

Weil, A., 2006: Why I still take my daily fish oil. Time 167(26): 74-74

Anonymous, 1973: Round table discussion on the role of hormonotherapy in cancerology. Les Cahiers de Medecine 14(2): 123-140

Kees Hertog,Bas Sorgdrager, 2013: Bedrijfsartsen zijn onbewust bekwaam. Jos Verbeek is bedrijfsarts-onderzoeker, nieuwsgierig naar het medisch handelen van vooral bedrijfsartsen. De bedrijfs- en verzekeringsarts die zich verdiept in de effectiviteit van het handelen komt de evidence-based methodieken van Jos Verbeek s...

Virsu, V., 1969: Denotative Meaning of "Quantitative' Adjectives and Adverbs. Journal of General Psychology 81(1): 35-44