geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Endocannabinoid signaling and energy metabolism: a target for dietary intervention


, : Endocannabinoid signaling and energy metabolism: a target for dietary intervention. Nutrition 27(6): 624-632

The endocannabinoid (EC) signaling (ECS) system involves the activation of receptors targeted by endogenously produced ligands called endocannabinoids that trigger specific physiologic events in various organs and tissues throughout the body. ECs are lipid mediators that bind to specific receptors and elicit cell signaling. The focus of this review is to discuss the responses that direct pathways of systemic energy metabolism. Recent findings have indicated that an imbalance of the ECS contributes to visceral fat accumulation and disrupts energy homeostasis, which are characteristics of the metabolic syndrome. Constant activation of ECS has been linked to metabolic processes that are associated with the hypothalamus and peripheral tissues of obese patients. In contrast, inhibition of ECS results in weight loss in animal and human subjects. Despite these findings, the mechanism involved in the dysregulation of ECS is unclear. Interestingly, the level of endogenous ligands, derived from arachidonic acid, can be directly manipulated by nutrient intervention, in that a diet rich in long-chain ω-3 polyunsaturated fatty acids will decrease the production of ligands to modulate the activation of target receptors. In contrast, a diet that is high in ω-6 polyunsaturated fatty acids will cause an increase in ECS activation and stimulate tissue specific activities that decrease insulin sensitivity in muscle and promote fat accumulation in the adipose tissue. The purpose of this review is to explain the components of ECS, its role in adipose and muscle energy metabolism, and how nutritional approaches with dietary ω-3 polyunsaturated fatty acids may reverse the dysregulation of this system to improve insulin sensitivity and control body fat.

US$19.90

PMID: 21470818

DOI: 10.1016/j.nut.2010.11.003


Other references

Moreno-Jiménez, Iés.; Kanczler, J.M.; Hulsart-Billstrom, G.; Inglis, S.; Oreffo, R.O.C., 2017: The Chorioallantoic Membrane Assay for Biomaterial Testing in Tissue Engineering: A Short-Term In Vivo Preclinical Model. The fields of regenerative medicine and tissue engineering offer significant promise to address the urgent unmet need for therapeutic strategies in a number of debilitating conditions, diseases, and tissue needs of an aging population. Critically,...

Oy, H., 1966: The relative value of different tree sizes as raw material for the chemical and mechanical pulp and sawmilling industries. The report for the chemical pulp industry has been published and that for the mechanical pulp industry is to be published. This paper reports briefly on the results of a study of 1385 logs, converted at a circular-saw mill. Subjects discussed incl...

Ahn, J-Hyun.; Son, E.Ju.; Kim, J-Ah.; Youk, J.Hyun.; Kim, E-Kyung.; Kwak, J.Young.; Ryu, Y.Hoon.; Jeong, J., 2010: The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer. The presence of axillary lymph node metastasis is the most important prognostic factor and an essential part of staging and prognosis of breast cancer. To elucidate the usefulness and accuracy of ultrasonography (US), fluorodeoxyglucose positron e...

Anonymous, 1997: Everything is okay with the HACCP (Hazard Analysis Critical Control Point) system. Self-regulation in the food trade receives more support. The German Food Hygiene Law (LMHV), due to come into force in the middle of 1997, is presented and discussed with reference to the dairy industry and the retail of milk products. The LMHV is the national counterpart to EU Directive 93/43 EWG regar...

Herz, W.; Subramaniam, P.S.; Murari, R.; Dennis, N.; Blount, J.F., 1977: Micordilin, a complex elemanolide from Mikania cordifolia. Journal of Organic Chemistry 42(10): 1720-1725

Volkova, V.M., 1975: Functional-esthetic clothes for invalids with defects of the upper limbs. Ortopediia Travmatologiia i Protezirovanie: 31-33

Stubenrauch, J.M., 2008: Nurses' vigilance leads to discovery of new syndrome. American Journal of Nursing 108(10): 25-26

Fredeen F.J.H.; Saha J.G.; Royer L.M., 1971: Residues of ddt dde and ddd in fish in the saskatchewan river after using ddt as a black fly larvicide for 20 years. Journal of the Fisheries Research Board of Canada 28(1): 105-109

Pauksen, K.; Duraj, V.; Ljungman, P.; Sjölin, J.; Oberg, G.; Lönnerholm, G.; Fridell, E.; Smedmyr, B.; Simonsson, B., 1992: Immunity to and immunization against measles, rubella and mumps in patients after autologous bone marrow transplantation. Humoral immunity to measles, rubella and mumps was studied in 63, 36 and 16 patients 1, 2 and 3 years, respectively after autologous bone marrow transplantation (ABMT). Serologic examination was performed using antibody-ELISA. One year after ABMT,...

Porter, T.R., 1997: Thrombolytic agents and methods of treatment for thrombosis. Official Gazette of the United States Patent & Trademark Office Patents 1200(3): 2035, July 15