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Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death


, : Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death. American Journal of Physiology. Heart and Circulatory Physiology 296(6): H1804-H1810

Ventricular myocytes are known to show increased expression of the cardiac hormones atrial and brain natriuretic peptide (ANP and BNP, respectively) in response to pathological stress on the heart, but their function during the progression of nonischemic dilated cardiomyopathy remains unclear. In this study, we crossed a mouse model of dilated cardiomyopathy and sudden death, which we generated by cardioselectively overexpressing a dominant-negative form of the transcriptional repressor neuron-restrictive silencer factor (dnNRSF Tg mice), with mice lacking guanylyl cyclase-A (GC-A), a common receptor for ANP and BNP, to assess the effects of endogenously expressed natriuretic peptides during progression of the cardiomyopathy seen in dnNRSF Tg mice. We found that dnNRSF Tg;GC-A(-/-) mice were born normally, but then most died within 4 wk. The survival rates among dnNRSF Tg;GC-A(+/-) and dnNRSF Tg mice were comparable, but dnNRSF Tg;GC-A(+/-) mice showed greater systolic dysfunction and a more severe cardiomyopathic phenotype than dnNRSF Tg mice. Collectively, our findings suggest that endogenous ANP/BNP protects the heart against the death and progression of pathological remodeling in a mouse model of dilated cardiomyopathy and sudden death.

US$19.90

PMID: 19346456

DOI: 10.1152/ajpheart.01033.2008


Other references

Hill, E.F., 1984: Hydrogen separation using coated titanium alloys. Hydrogen is separated from other fluids by selective absorption by a titanium alloy comprising ~ 14 wt % vanadium, ~ 11 wt % chromium, ~ 3 wt % aluminum, and balance titanium, stabilized in the body centered cubic crystalline form. The alloy has a...

Duba A., 1979: High electrical conductivity does not an asthenosphere make. Eos, Transactions, American Geophysical Union 60(18): 241-242

Vasserman, I.N.; Matveenko, V.P.; Shardakov, I.N.; Shestakov, A.P., 2016: Mechanism of Formation of Cardiac Arrhythmia Due to Pathological Distribution of Myocardium Conductivity. Two mechanisms responsible for the emergence of arrhythmia are known: a change of part of the cells to a self-oscillatory mode and generation of circulating waves. In this paper, we investigate the generation mechanism of the circulating waves usi...

Budai, A., 1974: Comparative examinations with the conventional and ultrasonic ophthalmodynamometer. Klinische Monatsblatter für Augenheilkunde 164(3): 364-367

L.P.chon, Céline.; Gorges, G.; Boët, P.; Baudry, J.; Goreaud, Fçois.; Faure, T., 2006: A spatially explicit resource-based approach for managing stream fishes in riverscapes. The article describes a riverscape approach based on landscape ecology concepts, which aims at studying the multiscale relationships between the spatial pattern of stream fish habitat patches and processes depending on fish movements. A review of...

Lee, K.Hye.; Jang, Y.; Chung, J.Hyung., 2011: Heat shock protein 90 regulates IκB kinase complex and NF-κB activation in angiotensin II-induced cardiac cell hypertrophy. Heat shock protein 90 (HSP90), one of the most abundant proteins in the cardiac cells is essential for cell survival. Previous studies have shown that angiotensin II induces cardiac cell hypertrophy. However, the role of HSP90 in the angiotensin I...

Korinthenberg, Rudolf, 1993: Morphological and functional maturation of the brain Possible relations to different EEG generators. Zschocke, St , Speckmann, E -J Brain Dynamics Series; Basic mechanisms of the EEG : 303-315

Cheah, C.Y.; Nastoupil, L.J.; McLaughlin, P.; Fanale, M.A.; Neelapu, S.S.; Fayad, L.E.; Hagemeister, F.B.; Fowler, N.H., 2015: Premature closure of a phase II study of bendamustine, mitoxantrone and rituximab for patients with untreated high-risk follicular lymphoma due to severe haematological and infectious toxicity. British Journal of Haematology 175(3): 531-533

Krotova, T.A.; Gerasimova, M.V., 1966: Bacteremia in leukosis. 3. A study of cultures isolated from the blood and other tissues of patients with acute leukosis. Problemy Gematologii i Perelivaniia Krovi 11(8): 10-20

Choudhury A., 1990: Overlapping distribution of capped langur trachypithecus pileata and phayres leaf monkey trachypithecus phayrei. Journal of the Bombay Natural History Society 87(1): 133