+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Enhanced biocompatibility and biostability of CdTe quantum dots by facile surface-initiated dendritic polymerization

, : Enhanced biocompatibility and biostability of CdTe quantum dots by facile surface-initiated dendritic polymerization. Biomacromolecules 10(7): 1865-1874

The synthesis of stable, low toxic, multifunctional, and water-soluble quantum dots (QDs) is of crucial importance for nanobiotechnology. An in situ anionic ring-opening polymerization strategy was successfully employed to grow multihydroxyl hyperbranched polyglycerol (HPG) from surfaces of aqueous synthesized QDs directly, affording multifunctional CdTe@HPG nanohybrids. The grafted HPG content can be adjusted from about 25 to 80 wt % by manipulating the feed ratio of glycidol monomer to QDs. The resultant CdTe@HPGs still show strong fluorescence and well water-solubility, and can conjugate functional biomolecules (e.g., amino acids) with their multiple reactive hydroxyls. Cytotoxicity measurements reveal that the CdTe@HPGs are much less toxic than the pristine QDs in human lung cancer cells SPCAI and more grafted HPG leads to less toxicity, due to the envelope of biocompatible HPG on QDs. It was found that the pristine QDs were unstable and their fluorescence decreased greatly or was even completed quenched after 24 h in SPCAI cells, whereas the QD@HPGs still exhibited strong fluorescence. This report opens the door for using in situ controlled/living polymerization to tailor QDs with biocompatible dendritic polymers readily and casts a light for obtaining robust nontoxic functionalized QDs and applying them in vitro and in vivo.


PMID: 19496613

DOI: 10.1021/bm9002877

Other references

Fox, E.A.; Mcgeehan, L.; Czekala, N.M., 1999: The function of female mate choice in the Sumatran orangutan. American Journal of Primatology 49(1): 53

Scagnelli, A.M.; Tully, T.N., 2017: Reproductive Disorders in Parrots. Disease affecting the reproductive tract of the companion parrot is often impacted by physiologic and environmental stimuli. In conjunction with appropriate medical management, some birds diagnosed with reproductive disorders may be successfully t...

Sushila Rai; Choudhary, R.B.; Madan, N.K.; Ghosh, P.K., 1993: Boron content of piezometric well waters of Suratgarh and Hanumangarh. Boron concn in 60 water samples from piezometric wells in Suratgarh and Hanumangarh, Rajasthan, India, were 0.2-13.0 mg/litre, with an average of 3.0 mg/litre. EC values ranged from 5.9 to 43.5 dS/m and averaged 27.9 dS/m. Average concn for chlori...

Lagios, M.D., 2005: DCIS: use of biomarkers and morphology to predict concurrent invasion. Breast Journal 11(1): 1-1

Coughtrey, PJ.; Martin, MH., 1977: The uptake of lead, zinc, cadmium, and copper by the pulmonate mollusc, Helix aspersa Muller, and its relevance to the monitoring of heavy metal contamination of the environment. Oecologia, 271: 65-74

Van Inwegen, R.G.; Nuss, G.W.; Carnathan, G.W., 1989: Antagonism of peptidoleukotrienes and inhibition of systemic anaphylaxis by RG 12525 in guinea pigs. RG 12525 was determined to be a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, in several assays utilizing guinea pigs. In vitro, RG 12525 competitively inhibited 3H-LTD4 binding to lung memb...

Lee, N.; Coxeter, P.; Beckmann, M.; Webster, J.; Wright, V.; Smith, T.; Kildea, S., 2011: A randomised non-inferiority controlled trial of a single versus a four intradermal sterile water injection technique for relief of continuous lower back pain during labour. Almost one third of women suffer continuous lower back pain during labour. Evidence from three systematic reviews demonstrates that sterile water injections (SWI) provide statistically and clinically significant pain relief in women experiencing c...

Chmil, J.Victor.; Turk, M.; Adamson, K.; Larew, C., 2016: Effects of an Experiential Learning Simulation Design on Clinical Nursing Judgment Development. Simulation design should be theory based and its effect on outcomes evaluated. This study (1) applied a model of experiential learning to design a simulation experience, (2) examined how this design affected clinical nursing judgment development,...

Cohen, L.L.; Bernard, R.S.; Greco, L.A.; McClellan, C.B., 2002: A child-focused intervention for coping with procedural pain: are parent and nurse coaches necessary?. To examine the efficacy of training children to cope with immunization pain without the assistance of trained coaches and determine whether untrained parents or nurses are more effective at decreasing children's distress. We compared the proc...

Sharpley Andrew N.; Hedley Mike J.; Sibbesen Erik; Hillbricht Ilkowska Anna; House; Ryszkowski Lech, 1995: Phosphorus transfers from terrestrial to aquatic ecosystems. SCOPE (Chichester) 54: 171-199