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Ethambutol neuroretinopathy

, : Ethambutol neuroretinopathy. Seminars in Ophthalmology 22(3): 141-146

To describe the clinical features of ethambutol neuroretinopathy. Case report and meta-analysis of the literature. A patient with clinical and electrophysiological findings suggestive of ethambutol neuroretinopathy. Electroretinogram, electro-oculogram and visual fields. Clinical and electrophysiological findings. 101 cases were reviewed, retinal findings include retinal pigment epithelial changes, macular edema, flame-shaped hemorrhages. Electroretinogram findings include decreased amplitude and abnormal wave pattern in full field ERG, multifocal or pattern ERG and electro-oculogram findings include abnormal Arden ratio. Clinical, electrophysiological and in vitro studies support the toxic effect of ethambutol on the retina. Therefore ethambutol ocular toxicity may be a neuroretinopathy.


PMID: 17763233

DOI: 10.1080/08820530701457134

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