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Etiology and short-term prognosis of severe mitral regurgitation

, : Etiology and short-term prognosis of severe mitral regurgitation. International Journal of Cardiovascular Imaging 25(2): 121-126

To describe the etiology and to document the course of severe mitral regurgitation (MR). Prospective registry of 272 patients diagnosed with chronic severe MR in an echocardiographic study. Mean age was 70.2 +/- 13.8 years and 143 patients were women (53%). The most frequent causes of regurgitation were rheumatic disease (72 patients; 26%), ischemic etiology (58; 21%), valve prolapse (57; 21%), and dilated cardiomyopathy (49; 18%). A total of 43 patients (16%) died during follow-up (mean 0.9 +/- 0.3 years, total 2,785 patient-months): 30 from cardiac causes, 9 from non-cardiac causes, and 4 from unknown causes. Actuarial transplant-free survival was 87% at 6 months, and 81% at 1 year. Renal disease, previous stroke, ischemic etiology, and poor left ventricular ejection fraction were independent predictors of mortality. Rheumatic disease is still the main cause of severe MR in Spain. Patients with severe MR have advanced age and present poor short-term prognosis.


PMID: 18777106

DOI: 10.1007/s10554-008-9363-8

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