+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Evaluation of correlation between pulmonary function testing and high resolution computed tomography in pulmonary alveolar proteinosis

, : Evaluation of correlation between pulmonary function testing and high resolution computed tomography in pulmonary alveolar proteinosis. Zhonghua Jie He He Hu Xi Za Zhi 31(7): 505-508

Pulmonary alveolar proteinosis (PAP) is a rare respiratory disorder featured by lipoproteinaceous material accumulation within alveoli. Pulmonary function testing (PFT) and quantitative high resolution computed tomography (HRCT) are used in evaluation of the severity, development and treatment effects of PAP. Seventeen patients (10 males, 7 females), aged from 15 to 51 years old, with PAP histopathologically proven by positive periodic acid Schiff reaction were studied in our institute from 2004 to 2007. PFTs and HRCT were performed in all patients. The quantitative parameters of HRCT included total lung volume (TLV), total lung mass (TLM), air-filling lung volume (AFLV), averaged lung density (ALD) and the ratio of air-filling lung volume to total lung volume (AFLV/TLV). The parameters of PFT included forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, diffusion capacity of carbon monoxide (D(L)CO), the ratio of D(L)CO to alveolar volume (D(L)CO/V(A)), total lung capacity (TLC), residual volume (RV), RV/TLC. A total of 24 dataset of the PFT and HRCT were collected. The correlation and regression between PFTs and HRCT were analyzed. PFT and HRCT parameters were compared before and after treatment with whole lung lavage in 6 of these patients. The data were expressed with mean +/- standard deviation and analyzed with SPSS 13.0 software. Restrictive ventilation function disorder and diffusion function disorder were found in patients with PAP, with more significant decline in D(L)CO (46.1% of predicted and abnormal rate 94.1%). Correlation between PFTs and HRCT parameters were found, with significance in ALD and FVC (r = -0.469, P = 0.021), TLM and FEV1 (r= -0.482, P = 0.017), AFLV/TLV and PEF (r = 0.511, P = 0.011), D(L)CO and D(L)CO/V(A) (r = 0.659, 0.692, P = 0.000, respectively). The highest correlation was found between D(L)CO/V(A) and AFLV (r = 0.525; P < 0.05). D(L)CO was markedly improved after the treatment of whole lung lavage, simultaneously found with varied improvement of quantitative parameters of HRCT measurements. Pulmonary function was impaired and correlated with abnormal appearance in HRCT in patients with PAP. Quantitative HRCT may be helpful in prediction of pulmonary function changes. Both techniques are important for the prognosis, outcome and follow-up studies of the disease.


PMID: 19035229

Other references

Lutyk, P., 1984: Eating of the larger pine-shoot beetle (Myelophilus=Tomicus piniperda L.) in shoots of spruce and fir. Sylwan 128(3): 65-68

Ikeda, H.; Enooku, K.; Ohkawa, R.; Koike, K.; Yatomi, Y., 2013: Plasma lysophosphatidic acid levels and hepatocellular carcinoma. Hepatology 57(1): 417-418

Braun, N.; Frank, J.; Biesalski, H.K.; Risler, T., 2000: Antioxidative treatment retards progression of idiopathic membranous nephropathy. Nephron 86(2): 208-209

Fromentin, H., 1959: Trypanolytic crises and antigenic variations of Trypanosoma gambiense in mice. In experimentally infected mice treated with subcurative doses of tryparsamide (causing temporary disappearance of the trypano-somes from the blood stream) the parasites which subsequently reappeared in the blood stream belonged to a different ant...

Stough, D., 2007: Dutasteride improves male pattern hair loss in a randomized study in identical twins. This study compared the efficacy of dutasteride vs. placebo in the treatment of male pattern hair loss (androgenetic alopecia) in 17 pairs of identical twin males with androgenetic alopecia over a 1-year period. In this randomized, double-blind, p...

Kuether, C.A.; Meyer, C.E.; Smith, A.H., 1940: Metabolism of free citric acid in the rat. Citric acid administered to the rat is absorbed since no extra citric acid appears in the feces and intestinal contents do not destroy it. The albino rat has the ability to completely metabolize maximum non-fatal quantities of free citric acid.

Culgin B.M.; Goodwin T.A.; Fox D.L., 2002: Mercury in till and bedrock, Kejimkujik National Park, Nova Scotia. Atlantic Geology 38(1): 80

Pringle, M., 2012: Understanding the prevalence of long-term conditions. Journal of Primary Health Care 3(4): 260-260

Delezir J.; Guy M., 1990: Digital remote sensing techniques applied to old aerial photographs. Photo Interpretation 29(2): 71-88

Imai Y., 1973: Surgery for acute ventricular septal defect. Journal of the Japanese Association for Thoracic Surgery 21(12): 1196