+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Evaluation of the morphological changes of gastric mucosa induced by a low concentration of acetic acid using a rat model

, : Evaluation of the morphological changes of gastric mucosa induced by a low concentration of acetic acid using a rat model. Journal of Forensic and Legal Medicine 22: 99-106

Oral ingestion of concentrated acetic acid causes corrosive injury of the gastrointestinal tract. To assess the effects of a low concentration of acetic acid on gastric mucosa, we examined the gastric mucosal changes in rats at 1 and 3 days after the injection of 5% or 25% acetic acid into the gastric lumen. The area of the gastric ulcerative lesions in the 25% acetic acid group was significantly larger than that in the 5% acetic acid group. The lesion area was reduced significantly at 3 days after injection in the 5% acetic acid group, whereas no significant difference in lesion area was observed at 1 and 3 days in the 25% acetic acid group. Histologically, corrosive necrosis was limited to the mucosal layer in the 5% acetic acid group, whereas necrosis extended throughout the gastric wall in the 25% acetic acid group. At 3 days post-injection, the 25% acetic acid group showed widespread persistent inflammation, whereas the 5% acetic acid group showed widespread appearance of fibroblasts indicative of a healing process. These results indicate that a low concentration of acetic acid damages the gastric mucosa and that the degree of mucosal damage depends on the concentration of acetic acid.


PMID: 24485432

DOI: 10.1016/j.jflm.2013.12.016

Other references

Schmidt-Posthaus, H.; Bettge, K.; Forster, U.; Segner, H.; Wahli, T., 2012: Kidney pathology and parasite intensity in rainbow trout Oncorhynchus mykiss surviving proliferative kidney disease: time course and influence of temperature. Proliferative kidney disease (PKD) is an endoparasitic disease of salmonids caused by the myxozoan parasite Tetracapsuloides bryosalmonae. We recently described the development of the disease from initial infection until manifestation of clinical...

Tyteca, E.; Guillarme, D.; Desmet, G., 2015: Use of individual retention modeling for gradient optimization in hydrophilic interaction chromatography: separation of nucleobases and nucleosides. In this study, the separation of twelve nucleobases and nucleosides was optimized via chromatogram simulation (i.e., prediction of individual retention times and estimation of the peak widths) with the use of an empirical (reversed-phase) non-line...

Holmes, M.A.; Harrison, E.M.; Fisher, E.A.; Graham, E.M.; Parkhill, J.; Foster, G.; Paterson, G.K., 2016: Genomic Analysis of Companion Rabbit Staphylococcus aureus. In addition to being an important human pathogen, Staphylococcus aureus is able to cause a variety of infections in numerous other host species. While the S. aureus strains causing infection in several of these hosts have been well characterised,...

Kovac P.; Petrakova E., 1980: Synthesis of 2 o beta d xylopyranosyl d xylose. Benzylation of benzyl 2,3-anhydro-.beta.-D-ribopyranoside with benzyl bromide and sodium hydride in 1,2-dimethoxyethane, followed by treatment of the formed, corresponding 4-O-benzyl derivatives with benzyl alcoholate anion in benzyl alcohol, gave...

Rosenberg, N.J., .: Effects of windbreaks on the microclimate, energy balance and water use efficiency of crops growing on the Great Plains. The calculated and observed effects of windbreaks on microclimate and plant and soil moisture responses to micrometeorological changes resulting from windbreaks and tree shelter belts are reviewed.

Yoon H.; Pabich E.K.; Gulyas K.; Dixon C.; Donahue T.F., 1990: Gene products that mediate translation initiation in saccharomyces cerevisiae. Yeast 6(SPEC ISSUE): S32

Kuffler, S.W.; Dennis, M.J.; Harris, A.J., 1971: The development of chemosensitivity in extrasynaptic areas of the neuronal surface after denervation of parasympathetic ganglion cells in the heart of the frog. Proceedings of the Royal Society of London. Series B, Biological Sciences 177(1049): 555-563

Haswell, W.A., 1882: Note on the Anatomy of two rare Genera of Pigeons. Proceedings of the Linnean Society of New South Wales, VII 115 & 116

Muzylev N.G.; Tabachnikova I.P.; Voronina A.A., 1992: Early Oligocene episode of freshening in Paratethys. International Geology Review 34(6): 598-610

Arsic Arsenijevic, V.; Milobratovic, D.; Dzamic, A.; Mitrovic, S.; Trpkovic, A.; Petkovic, L., 2003: The first isolation of Malassezia sp in Serbia. FEMS Congress of European Microbiologists Abstract Book (1): 463