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Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers

, : Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers. Chembiochem 10(7): 1141-1144

All in a knot. The smallest riboswitch forms a pseudoknot in solution. This is demonstrated for preQ(1) class I aptamers by mutational analysis in combination with (1)H NMR-based structure probing. How pseudoknot formation mediates the mRNA response through its expression platform is now open for investigation.


PMID: 19382115

DOI: 10.1002/cbic.200900155

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