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Evolution in health and medicine Sackler colloquium: The comparative genomics of viral emergence


, : Evolution in health and medicine Sackler colloquium: The comparative genomics of viral emergence. Proceedings of the National Academy of Sciences of the United States of America 107 Suppl 1: 1742-1746

RNA viruses are the main agents of emerging and re-emerging diseases. It is therefore important to reveal the evolutionary processes that underpin their ability to jump species boundaries and establish themselves in new hosts. Here, I discuss how comparative genomics can contribute to this endeavor. Arguably the most important evolutionary process in RNA virus evolution, abundant mutation, may even open up avenues for their control through "lethal mutagenesis." Despite this remarkable mutational power, adaptation to diverse host species remains a major adaptive challenge, such that the most common outcome of host jumps are short-term "spillover" infections. A powerful case study of the utility of genomic approaches to studies of viral evolution and emergence is provided by influenza virus and brought into sharp focus by the ongoing epidemic of swine-origin H1N1 influenza A virus (A/H1N1pdm). Research here reveals a marked lack of surveillance of influenza viruses in pigs, coupled with the possibility of cryptic transmission before the first reported human cases, such that the exact genesis of A/H1N1pdm (where, when, how) is uncertain.

US$19.90

PMID: 19858482

DOI: 10.1073/pnas.0906193106


Other references

Kuppi, H., 1954: The digitalis ECG and its reversibility under atropine. Zeitschrift für die Gesamte Innere Medizin und Ihre Grenzgebiete 9(17): 837-846

Barsotti, G.; Briganti, A.; Spratte, J.R.; Ceccherelli, R.; Breghi, G., 2014: Schirmer tear test type I readings and intraocular pressure values assessed by applanation tonometry (Tonopen® XL) in normal eyes of four European species of birds of prey. To determine normal values for Schirmer tear test I and intraocular pressure in four European species of birds of prey. Twenty birds from each of the following species: Eurasian Tawny owl (Strix aluco), Little owl (Athene noctua), Common buzzard (...

Cowart, L.E., 1952: Some herbicidal properties of CMU. Rates of 20 to 40 pounds per acre gave almost complete control for 1 year except for deep rooted perennials which may require up to 80 pounds per acre. As a pre-emergence treatment for control of weeds in cotton, sugarcane, corn, asparagus and car...

Neumayer, H.H.; Kienbaum, M.; Graf, S.; Schreiber, M.; Mann, J.F.; Luft, F.C., 1993: Prevalence and long-term outcome of glomerulonephritis in renal allografts. We report long-term results over 10 years in patients developing glomerulonephritis after renal transplantation. The prevalence rate of glomerulonephritis was 6.2% in 785 renal transplants involving 697 patients with end-stage renal disease. This...

Nikonchik, O.K., 1982: Development of the maternal and child welfare system in the USSR (1922-1982). Akusherstvo i Ginekologiia: 3-7

Lachaise, F.; Martin, G.; Drougard, C.; Perl, A.; Vuillaume, M.; Wegnez, M.; Sarasin, A.; Daya Grosjean, L., 2001: Relationship between posttranslational modification of transaldolase and catalase deficiency in UV-sensitive repair-deficient Xeroderma Pigmentosum fibroblasts and SV40-transformed human cells. Xeroderma Pigmentosum (XP) is a rare recessively inherited human disease associated with a hypersensitivity to ultraviolet radiation. The ultraviolet component of sunlight can initiate and promote the formation of cutaneous tumors as seen in the s...

Zhong, X.; Deng, J.; He, P.; You, N.; Wang, Q.; Song, B.; Li, L., 2013: Reverse mode of the sodium/calcium exchanger subtype 3 in interstitial cells of Cajal from rat bladder. To investigate how the sodium/calcium exchanger subtype 3 (NCX3) and its reverse mode contribute to the function of interstitial cells of Cajal (ICCs) from the rat bladder. The study used 20 female Wistar rats. We observed the expression of the NC...

Eitoku, T.; Nakasone, Y.; Zikihara, K.; Matsuoka, D.; Tokutomi, S.; Terazima, M., 2007: Photochemical intermediates of Arabidopsis phototropin 2 LOV domains associated with conformational changes. The photochemical reactions of Arabidopsis phototropin 2 light- oxygen-voltage domain 2 (LOV2) with the linker region (LOV2-linker), without the linker (LOV2), and LOV1 were studied using the time-resolved transient grating (TG) and transient lens...

Oshodin, O.G.; Ujiro, I., 2007: Influence of norm of family size of policemen on family planning in Oredo Local Government Area of Edo State, Nigeria. The purpose of this study was to investigate the influence of norm of family size of policemen on family planning in Oredo Local Government Area of Edo State, Nigeria. The population for this study comprised all the policemen in the six divisional...

Packard D.S.Jr; Schwartz G.; Nolan R.; Farquarson S.; Degennaro L.D., 1991: Skeletal malformations and hematomas in chicken embryos treated with fluorodeoxyuridine. Anatomical Record 229(4): 67A-68A