geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Examining stage IIB survival in a population-based cohort of patients with colorectal cancer


, : Examining stage IIB survival in a population-based cohort of patients with colorectal cancer. Cancer 118(23): 5973-5981

In Nova Scotia, Canada, a previous study of colorectal cancer (CRC) cases diagnosed between January 1, 2001, and December 31, 2005, found that patients with stage IIB CRC had similar 5-year overall survival (OS) to those with stage IIIC cancer. This study sought to examine factors contributing to the observed stage IIB outcome, specifically nodal harvest, receipt of chemotherapy, and use of a new coding system to derive stage. The provincial cancer registry identified all CRC cases diagnosed during the study period and staged this cohort using the Collaborative Stage (CS) Data Collection System. All patients with stage II and III cancer in the cohort were examined. Kaplan-Meier (KM) survival curves compared 5-year OS for patients with stage IIB cancer based on the factors of interest, and compared patients with stage IIB cancer to those with stage IIA and III cancer. OS for patients with stage IIB cancer (n = 187) was 44.7%, and differed depending on adequacy of nodal harvest (P = .005) and whether pathological or clinical/mixed evidence was used to derive stage (P = .013). Pathologically-staged patients with stage IIB cancer who had adequate nodal harvest had marginally improved OS compared to pathologically-staged patients who had inadequate nodal harvest (P = .07), and improved survival compared to patients with clinical/mixed stage (P = .004). Pathologically-staged patients with stage IIB cancer with adequate nodal harvest demonstrated similar 5-year OS to those with stage IIA and III cancer (P = .52 and P = .25, respectively). Cox proportional hazards models supported these findings. The inclusion of clinical/mixed evidence into staging classification and, perhaps to a lesser extent, the adequacy of nodal harvest appear to contribute to the observed worse survival for patients with stage IIB versus stage III cancer.

US$19.90

PMID: 22648789

DOI: 10.1002/cncr.27610


Other references

Kostrikov, V.S.; Chesnokova, A.F., 1955: Anna Fedoseevna Chesnokova. Meditsinskaia Sestra: 30-31

Marks, L.B.; Kaidar-Person, O.; Poortmans, P., 2017: Regarding Current Recommendations for Postmastectomy Radiation Therapy in Patients With One to Three Positive Axillary Lymph Nodes. Journal of Clinical Oncology 35(11): 1256-1258

Jagannathan, V.K.; Nortcliffe, S.A., 2008: Potentially fatal vaporizer incident. European Journal of Anaesthesiology 25(2): 165-166

Berry, W., 1991: Living with the land. Journal of soil and water conservation 46(6): 390-393

Vorob yeva O.A., 1969: Evolution of alkalic plutonic rocks within the tectonic structures of the Earth's crust. Pages 87-90 1969

Coleman Neil; Marsh Bruce D., 2007: Reduced likelihood of volcanic disruption of a geologic repository at Yucca Mountain. We use past volcanic activity to examine the likelihood of future igneous activity at Yucca Mountain, a potential site for a geologic repository for disposal of high-level radioactive waste. We previously tested claims that basaltic dikes could pe...

Aoki, N.; Yube, K.; Mae, K., 2007: Fluid segment configuration for improving product yield and selectivity of catalytic surface reactions in microreactors. Ordered laminar flow and mixing driven mainly by molecular diffusion in microreactors enables operation using fluid segments. This paper discusses the effects of configuration of fluid segments including reactants at the reactor inlet for catalyt...

Walther, J., 1930: Goethe als Seher nnd Erforscher der Natur. Untersuchungen uber Goethes Stellung zu den Problemen der Natur. Unknown

Smalley, S.L.; Mccracken, J.; Mcgough, J., 2001: Refining the ADHD phenotype using affected sibling pair families. Attention deficit hyperactivity (ADHD) is a highly heritable behavioral disorder characterized by symptoms of inattention, hyperactivity, and/or impulsivity. Detection of susceptibility genes underlying ADHD may benefit from refinement of the ADHD...

Lamy, E., 1916: Description d'un Lamelli-branche nouveau du Golfe de Californie. Paris BullHist. Nat: 443-445