+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes

, : Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes. Journal of Immunology 181(5): 3167-3176

Astrocytes play a number of important physiological roles in CNS homeostasis. Inflammation stimulates astrocytes to secrete cytokines and chemokines that guide macrophages/microglia and T cells to sites of injury/inflammation. Herein, we describe how these processes are controlled by the suppressor of cytokine signaling (SOCS) proteins, a family of proteins that negatively regulate adaptive and innate immune responses. In this study, we describe that the immunomodulatory cytokine IFN-beta induces SOCS-1 and SOCS-3 expression in primary astrocytes at the transcriptional level. SOCS-1 and SOCS-3 transcriptional activity is induced by IFN-beta through IFN-gamma activation site (GAS) elements within their promoters. Studies in STAT-1alpha-deficient astrocytes indicate that STAT-1alpha is required for IFN-beta-induced SOCS-1 expression, while STAT-3 small interfering RNA studies demonstrate that IFN-beta-induced SOCS-3 expression relies on STAT-3 activation. Specific small interfering RNA inhibition of IFN-beta-inducible SOCS-1 and SOCS-3 in astrocytes enhances their proinflammatory responses to IFN-beta stimulation, such as heightened expression of the chemokines CCL2 (MCP-1), CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CCL5 (RANTES), and CXCL10 (IP-10), and promoting chemotaxis of macrophages and CD4(+) T cells. These results indicate that IFN-beta induces SOCS-1 and SOCS-3 in primary astrocytes to attenuate its own chemokine-related inflammation in the CNS.


PMID: 18713987

Other references

Guo, J.; Pan, L-Hui.; Li, Y-Xi.; Yang, X-Di.; Li, L-Qun.; Zhang, C-Yan.; Zhong, J-Hong., 2016: Efficacy of triclosan-coated sutures for reducing risk of surgical site infection in adults: a meta-analysis of randomized clinical trials. Surgical site infection (SSI) is the third most frequent type of nosocomial infections. Triclosan-coated sutures are often used to reduce the risk of SSI, but studies examining this have given conflicting results. Therefore, this meta-analysis was...

Pirkis, J.; Spittal, M.J.; Cox, G.; Robinson, J.; Cheung, Y.Tak.Derek.; Studdert, D., 2013: The effectiveness of structural interventions at suicide hotspots: a meta-analysis. Certain sites have gained notoriety as 'hotspots' for suicide by jumping. Structural interventions (e.g. barriers and safety nets) have been installed at some of these sites. Individual studies examining the effectiveness of these interv...

An, H.S.; Lynch, K.; Toth, J., 1995: Prospective comparison of autograft vs. allograft for adult posterolateral lumbar spine fusion: differences among freeze-dried, frozen, and mixed grafts. The use of allografts continues today for the purpose of spinal fusion. The literature is conflicting on the effectiveness of allografts in spinal fusion as compared with autografts. Numerous variables affect fusion, including age, sex, smoking st...

Barth, S.; Haas, J-Peter.; Schlichtiger, J.; Molz, J.; Bisdorff, B.; Michels, H.; Hügle, B.; Radon, K., 2016: Long-Term Health-Related Quality of Life in German Patients with Juvenile Idiopathic Arthritis in Comparison to German General Population. Aims of the study were to investigate health-related quality of life (HRQOL) in adult patients with former diagnosis of Juvenile Idiopathic Arthritis (JIA), to compare their HRQOL with the general population and to identify factors related to a po...

Diester-Haass, L.; Billups, K.; Emeis, K.C., 2010: Marine biological productivity, carbon cycling, and climate cooling during the Oligocene to Miocene transition. Bonn, Germany (DEU): Deutsche Forschungsgemeinschaft

Ogaya Pinies, G.; Díez-Cordero, J.M.; Aragón Chamizo, J.; del Pozo Jiménez, G.; Lledó García, E.; Hernández Fernández, C., 2014: Bleeding in the immediate postoperative period after renal transplantation. Archivos Espanoles de Urologia 67(8): 729-730

Krivanek, J.O.; Krivanek, R.C., 1965: Evidence for transaminase activity in the slime mold, Dictyostelium discoideum Raper. Progressive chromatography and paper electrophoresis techniques have demonstrated qualitatively the occurrence of 2 transamlnating systems in D. discoideum. These systems are glutamic-aspartic (or glutamic-oxaloacetic) transaminase and glutamic-al...

Reverter, A.; Porto-Neto, L.R.; Fortes, M.R.S.; Kasarapu, P.; de Cara, M.A.R.; Burrow, H.M.; Lehnert, S.A., 2017: Genomic inbreeding depression for climatic adaptation of tropical beef cattle. Inbreeding has the potential to negatively impact animal performance. Strategies to monitor and mitigate inbreeding depression require that it can be accurately estimated. Here, we used genomewide SNP data to explore 3 alternative measures of geno...

D.Graça, H.M., 1966: New aspects of the pathology of cattle in Angola: mucosal isease and diarrhea caused by viruses in cattle. Bulletin - Office International des Epizooties 66(1): 389-394

Martin I.D.; Mackay R.J., 1983: Growth rates and prey selection of 2 congeneric predatory caddis flies trichoptera rhyacophilidae. Rhyacophila fuscula (Walker) and R. melita Ross inhabit cool southern Ontario [Canada] streams, often together. In laboratory experiments, R. fuscula and R. melita showed significant weight gains in 2 wk on 4 common prey taxa occurring in the fiel...